Synthesis and physical-chemical properties of 6-(5-(1Н-tetrazole-1-ylmethyl)-4-R-1,2,4-triazole-3-ylthio)pyridin- 3-amines and 6-((5-(1Н-tetrazole-1-yl)methil-4-R-1,2,4-triazole- 3-ylthio)pyridin-3-yl)-(alk,ar,heter)ylmethanimines

Over the past decade the number of publications, that contain different aspects of chemistry and use of triazoles and tetrazoles have been doubled and continues to grow. Publications of recent years show that heterocycles with 1,2,3,4-teterazoles and 1,2,4-triazoles are biologically active compounds with a broad spectrum of action. This fact indicates the interest to these compounds as potential objects of modern pharmaceutical market, namely to those compounds which contain both heterocycles.

Conclusions.The results of our work have confirmed the structure of the synthesized compounds, which indicates the possibility of their further use in biological studies.

Introduction
Creating of new drugs is an important task of nowadays pharmacy and medicine.Foreign drugs are more expensive than domestic ones.That is why search of new domestic biologically active compounds is actual.
During the past decade the number of publications that contain different aspects of triazoles and tetrazoles have been doubled and continues to grow.Literature sources over the last few years [1][2][3][4][5][6][7] show that compounds containing 1,2,4-triazole and 1,2,3,4-teterazole nucleus establish highly biological activity and broad spectrum of action.This fact indicates the interest for these compounds as potential objects of modern pharmaceutical market.

Materials and methods
Physical-chemical properties of the synthesized compounds have been investigated according to the methods described in the State Pharmacopeia of Ukraine [8,9].The melting point has been determined by capillary method (2.2.14).The elemental composition of compounds has been set with the help of elemental analyzer Elementar Vario ЕL cube (CHNS) (standard -Sulfonamide). 1 H NMR spectra of obtained compounds has been set with the help of Varian Mercury VX-200 (1Н, 200 MHz), solvent -DMSO-d6, internal standart -Tetramethylsilane (TMS).Chromatography-mass spectrometry studies have been conducted on gas-liquid chromatograph Agilent 1260 Infinity HPLC equipped with a mass spectrometer Agilent 6120 (in electrospray ionization (ESI)) [10,11].

Table 5 .
The

Table 6 .
NMR confirmed by chromatography-mass spectrometry on gas-liquid chromatograph Agilent 1260 Infi nity HPLC equipped with a mass spectrometer Agilent 6120 (ionization in electrospray (ESI)).