Gender features of heart failure with preserved ejection fraction in patients with myocardial infarction on the background of hypertension

Authors

  • V. D. Syvolap Zaporizhzhia State Medical University, https://orcid.org/0000-0002-7342-9065
  • O. V. Nazarenko Zaporizhzhia State Medical University,
  • Ya. V. Zemlyaniy Zaporizhzhia State Medical University,

DOI:

https://doi.org/10.14739/2310-1210.2017.3.100567

Keywords:

heart failure, growth differentiation factor 15, myocardial infarction, hypertension

Abstract

Actuality of chronic heart failure problem remains due to its increasing prevalence in all developed countries, includingUkraine.

The aim – to evaluate the gender features in patients with heart failure with preserved ejection fraction after myocardial infarction on the background of hypertension.

Materials and Methods. The study involved 72 patients (50 men and 24 women) with heart failure and preserved ejection fraction after myocardial infarction on the background of hypertension (the average age was 64.1 ± 0.97 years). Patients were divided into two groups according to gender. Evaluation of intracardiac hemodynamics was carried out by echocardiography on the device “VIVID 3 Expert” (“General Electric”,USA) using the standard method with tissue Doppler. Levels of GDF 15 and NTproBNP in blood serum were identified by use the ELISA kits of Human GDF 15/MIC-1 ELISA (“BioVendor”,Czech Republic) and NTproBNP ELISA Kit (“Biomedica”,SlovakRepublic).

Results. Clinical condition of women with heart failure and preserved ejection fraction after myocardial infarction on the background of hypertension was more severe, which was confirmed by significantly higher scores on the scale of clinical status assessment (40 %, p < 0.05) and reduction the distance covered (33.4 %; p < 0.05), and more points on the Borg’s scale (22.6 %; p < 0.05) according to 6-minute walking test. In female patients significant increasing in E/E' ratio (by 12.2 %, p < 0.05) and GDF 15 serum levels (by 30.3 %, p < 0.05) was found compared to male patients. In women with heart failure and preserved ejection fraction after myocardial infarction on the background of hypertension, the total mortality rate within 3 years was significantly higher (16 %) than men (10 %).

Conclusions. Female patients with heart failure and preserved ejection fraction after myocardial infarction on the background of hypertension had a severe course of the disease, as evidenced by a lower exercise tolerance, diastolic function impairment and the worsening of three-year survival prognosis.

References

Voronkov, L. G., Amosova, K. M., Bahrii, A. E., Dziak, H. V., Diadyk, O. I., Zharinov, O. Y., et al. (2012) Rekomendatsii z diagnostyky ta likuvannia khronichnoi sertsevoi nedostatnosti (2012) [Guidelines for the diagnosis and treatment of chronic heart failure (2012)]. Kyiv. [in Ukrainian].

Коzhukhov, S. M., & Parkhomenko, O. M. (2016) Sertseva nedostatnist zi zberezhenoiu fraktsiieiu vykydu livoho shlunochka [Heart failure with preserved left ventricular ejection fraction]. Medytsyna nevidkladnykh staniv, 1, 126–130. [in Ukrainian].

Cowie, Mr., Fox, K. F., & Wood, D. A. (2002) Hospitalization of patients with heart failure: a population -based study. Eur. Heart. J. 23(11), 877–885.

Deswal, A., & Bozkurt, B. (2006) Comparison of morbidity in women versus men with heart failure and preserved ejection fraction. Am. J. Cardiol,. 97(8), 1228–1231. doi: 10.1016/j.amjcard.2005.11.042.

Bleumink, G. S., Knetsch, A. M., Sturkenboom, M. C., Straus, S. M., Hofman, A., Deckers, J. W., et al. (2004) Quantifying the heart failure epidemic: prevalence, incidence rate, lifetime risk and prognosis of heart failure The Rotterdam Study. Eur. Heart J., 25, 1614–1619. doi:10.1016/j.ehj.2004.06.038.

Lam, C. S., Carson, P. E., Anand, I. S., Rector, T. S., Kuskowski, M., Komajda, M., et al. (2012) Sex Differences in Clinical Characteristics and Outcomes in Elderly Patients With Heart Failure and Preserved Ejection Fraction: The Irbesartan in Heart Failure With Preserved Ejection Fraction (I-PRESERVE) Trial. Circ. Heart. Fail., 5(5), 571–578. doi: 10.1161/CIRCHEARTFAILURE.112.970061.

Maeder, M. T., & Kaye, D. M. (2009) Heart failure with normal left ventricular ejection fraction. J. Am. Coll. Cardiol., 53, 905–918. doi: 10.1016/j.jacc.2008.12.007.

Nagueh, S. F., Appleton, C. P., Gillebert, T. C., Marino, P. N., Oh, J. K., Smiseth, O. A., et al. (2009) Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography. Journal of the American Society of Echocardiography, 22, 107–133. doi: 10.1016/j.echo.2008.11.023.

Okura, H., Kubo, T., Asawa, K., Toda, I., Yoshiyama, M., Yoshikawa, J., & Yoshida, K. (2009) Elevated E/E’ predicts prognosis in congestive heart failure with preserved systolic function. Circ. J., 73, 86–91. doi: 10.1253/circj.CJ-08-0457.

Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G., Coats, A. J., et al. (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Eur. Heart. J., 18(8), 891–975. doi: 10.1002/ejhf.592.

Shah, K. S., & Maisel, A. S. (2014) Novel biomarkers in heart failure with preserved ejection fraction. Heart Fail Clin., 10(3), 471–479. doi: 10.1016/j.hfc.2014.04.005.

Downloads

How to Cite

1.
Syvolap VD, Nazarenko OV, Zemlyaniy YV. Gender features of heart failure with preserved ejection fraction in patients with myocardial infarction on the background of hypertension. Zaporozhye medical journal [Internet]. 2017May5 [cited 2024Apr.25];(3). Available from: http://zmj.zsmu.edu.ua/article/view/100567

Issue

No. 3 (2017)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)