Reproductologist’s current views on etiopathogenesis and treatment of uterine leiomyoma
DOI:
https://doi.org/10.14739/2310-1210.2017.3.100953Keywords:
leiomyoma, morphogenesis, reproductive health, care algorithmAbstract
Aim. To analyze specialized scientific literature for compilation of data about contemporary views on the uterus leiomyoma etiopathogenetic features, its clinical course and influence on woman’s reproductive function, and also to study data about modern methods of the uterus leiomyoma prophylaxis and treatment.
Leiomyoma is the most common benign uterine tumor of reproductive age which ranks second in the gynecologic diseases following uterus and appendages inflammation. There are data about molecular biology, genetics and immunehistochemistry features of diagnostic and treatment of the uterine leiomyoma in the article. Although many molecular-genetic determinants of the uterine leiomyoma have been lately discovered, however etiology and pathophysiology of disease have not been enough studied. Leiomyoma is a medical-social problem that results in the decline of capacity and violation of woman’s reproductive function, and also accompanied by range of obstetric and perinatal complications. This review provides analysis of conservative treatment modern methods and innovative technologies of uterine leiomyoma operative treatment in young women with unrealized reproductive plans.
Materials and Methods. Accessible scientific literature over the last five years concerning features of etiopathogenesis, clinical course and the modern methods of uterus leiomyoma treatment were studied and analyzed. Methods of gynecological observation, systemic and content-analysis were used.
Conclusions: Leiomyoma ranks second in the gynecologic diseases following uterus and appendages inflammation. In 20-30% of cases leoimyoma is etiological factor of infertility and in 15-30% of cases is the cause of miscarriage. Reproductive function of patients is actual gynecological and obstetrical problem and therefore its resolving is the step-by-step etiopathogenetic approuch depending on the patient’s age, their reproductive anamnesis, prasense of genital snd somatic pathology. Use of the modern conservative and surgical methods of uterine leiomyoma treatment gives possibility to decrease in rate of complications, to preserve the uterus and female reproductive function, to increase in treatment efficiency and life quality of these patients.
References
Török, P., & Póka, R. (2016) Diagnosis and treatment of uterinemyoma. Orv Hetil., 22, 157(21), 813–9. doi: 10.1556/650.2016.30435.
Osinovskaya, N. S., Ivashchenko, T. E., Dolinskii, A. K., Sultanov, I. Y., Ghimbovchi, S., Hoffman, E., et al. (2013) MED12 gene mutations in women with uterine myoma. Human Genetics, 49(12), 1245–1249. doi:10.1134/S1022795413120089.
Aliakparov, M. T., Abishev, B. Kh., Tazhibaev, D. M., & Pitel', E. S. (2014) Rezul'taty eʹmbolizacii matochnykh arterij v lechenii simptomnoj miomy matki [Results of uterine artery embolization in the treatment of symptomatic uterine myoma]. Vestnik rentgenologii i radiologii, 6, 29–32. [in Russian].
Vdovychenko, Yu. P., Holianovskyi, O. V., & Lopushyn, V. I. (2012) Leiomioma matky: etiopatohenez, profilaktyka, diahnostyka ta likuvannia [Leuomyomfa: etiopathogenesis, prophylaxis, diagnostic and treatment]. Zdorovʹya zhenshchiny, 3(69), 52–61. [in Ukrainian].
Veropotvelyan, P. N., Bondarenko, A. A., & Veropotvelyan, N. P. (2015) Mioma matki u zhenshchin reproduktivnogo vozrasta [Women of reproductive age uterine fibroids]. Zdorovʹya zhenshchiny, 10(106), 153–156. [in Russian].
Kosej, N. V., Vasilʹchenko, L. A., Sukhorebraya, E. I., & Shakalo, I. N. (2012) Princypy lecheniya lejomiomy matki [Principles of the uterinemyoma treatment]. Reproduktivnaya eʹndokrinologiya, 1(3), 14–20. [in Russian].
Lachinskuj, V. I., Ischenko, A. I., & Illarioshkin, C. N. (2004) Genetika I molekulyarnaya biologiya miomy matki [Genetic and moleculabiology of uterinemyoma]. Akusherstvo i ginekologiya, 2, 14–17. [in Russian].
Pamfamirov, Y. K., Zabolotnov, V. A., Karapetian, O. V., Volchenko, I. G., & Puchkina, G. A. (2013) Organosberegayushchij podkhod v lechenii miomy matki [The organ-preserving treatment of uterine myoma]. Zdorovʹya zhenshchiny, 1(77), 162–164. [in Russian].
Sidorova, I. S., & Ardus, N. V. (2002) Sovremennye patogeneticheskie aspekty miomy matki [Modern pathogeneticaspects of the uterinemyoma]. Rossijskij vestnik akushera-ginekologa, 3, 26–29. [in Russian].
Storozhuk, M. S., Protsepko, O. O., & Martynyshyn, O. B. (2012) Klinichna kharakterystyka zhinok reproduktyvnoho viku, khvorykh na miomu matky [Weman’s ClInIcal characteristic of reproductive age with uterinemyoma]. Zdorovʹya zhenshchiny, 7(73), 156–157. [in Ukrainian].
Tatarchuk, T. F. (2009) Sovremennye pryntsypy lechenyya [Uterineleuomyoma. Modernprinciples of the treatment]. Zrostai maliuk!, 22–23, 1–24. [in Ukrainian].
Frlolova, M. A. (2002) Gipoteza patogeneza formirovaniya i razvitiya miomy matki [Pathogenetichypothesis of occurren ceuterinemyoma]. Rossijskij vestnik akushera ginekologa, 1, 56–58. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
