Assessment of liver fibrosis stage influence on clinical course of periodontal diseases in patients with chronic hepatitis C

Authors

  • О. М. Slaba Lviv National Medical University, Ukraine,
  • L. Yu. Minko Lviv National Medical University, Ukraine,
  • Kh. A. Sichkoriz Lviv National Medical University, Ukraine,
  • І. О. Kiselyk Lviv National Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2017.4.104914

Keywords:

periodontal diseases, chronic hepatitis C (HCV), liver fibrosis

Abstract

The aim. To assess the influence of liver fibrosis stage on the clinical course of periodontal diseases in patients with chronic hepatitis C.

Material and Methods. 122 patients with chronic hepatitis C, treated at the 7th department ofLvivRegionalInfectiousDiseasesHospital during 2013 – 2015 were included into dental investigation. The periodontal disease was diagnosed in accordance with the classification of M. F. Danilevsky (1994). The clinical condition of periodontium was assessed by the papillary marginal alveolar index (PMA) in the modification ofParma, by the periodontal index – PI (AL Russel, 1956), by the Muhlemann and Son index – the degree of bleeding in the region of the gingival papilla (PBI). The stage of liver fibrosis was determined according to the medical history. The significance of the difference between two or more relative indicators was calculated using the Fisher test with the Metropolis algorithm. The correlation dependence between the clinical condition of periodontal tissues and the stage of liver fibrosis in patients with viral hepatitis C was studied using the Spearman rank correlation coefficient.

Results. The highest percentage of patients with stage of liver fibrosis F0 (70.00 ± 15.28 %) was registered in patients with healthy periodont, the lowest - in patients with generalized periodontitis of the third stage (7.89 ± 4.37 %). The highest frequency of patients with the stage of liver fibrosis F3 (73.68 ± 7.14 %) was also observed in persons suffering from generalized periodontitis stage III (73.68 ± 7.14 %).

Conclusions. The distribution of periodontal lesion severity statistically significant (p < 0.001) depended on the stage of liver fibrosis in patients with chronic hepatitis C. Direct (R = 0.70; p < 0.001) strong correlation between the clinical state of periodontal tissues and the stage of liver fibrosis in patients with chronic hepatitis C (using the Spearman rank correlation coefficient) has been determined

References

Linden, G. J., & Herzberg, M. C. (2013) Periodontitis and systemic diseases : a record of discussions of working group 4 of the Joint EFP/AAP Workshop on periodontitis and systemic diseases. J. Periodontol, 84(4), 20–23.. doi: 10.1111/jcpe.12091.

Ameet, M. M., Avneesh, H. T., Babita, R. P., & Pramod, P. M. (2013). The Relationship Between Periodontitis and Systemic Diseases – Hype or Hope?. J. Clin. Diagn. Res., 7(4), 758–762. doi: 10.7860/JCDR/2013/4500.2906.

Madaliński, K., Zakrzewska, K., Kołakowska, A., & Godzik, P. (2015). Epidemiology of HCV infection in central and eastern Еurope. Przegl Epidemiol, 69(3), 459–464.

Carrozzo, M. (2014). Oral manifestations of hepatitis C virus infection. World Journal of Gastroenterology, 20(24), 7534–7543. doi: 10.3748/wjg.v20.i24.7534.

Carrozzo, M., & Gandolfo, S. (2003). Oral Diseases Possibly Associated with Hepatitis C Virus. Critical Reviews in Oral Biology & Medicine, 14(2), 115–127.

Panov, V. (2013). Oral manifestations of hepatitis c virus. Journal of IMAB - Annual Proceeding (Scientific Papers), 19(4), 377–379.

Mahboobi, N., Porter, S., Karayiannis, P.,& Alavian, S. (2011). Oral fluid and hepatitis A, B and C: A literature review. Journal of Oral Pathology & Medicine, 41(7), 505–516. doi: 10.1111/j.1600-0714.2011.01123.x.

Danilevskij, N. F., & Borisenko, A. V. (2000). Zabolevaniya parodonta [Periodontal disease]. Kyiv: Zdorov´ya. [in Russian].

Vol'f, G. F., Ratejckhak, E´.M., & Ratejckhak, K. (2008). Parodontologiya [Parodontologie]. G.M. Barera (Ed). Moscow: MEDpress-inform. [in Russian].

Shiha, G., & Zalata, K. (2011) Ishak versus METAVIR: Terminology, Convertibility and Correlation with Laboratory Changes in Chronic Hepatitis C Retrieved from: http://www.intechopen.com/books/liver-biopsy/ishak-versus-metavirterminology-convertibility-and-correlation-with-laboratory-changes-in-chronic-hepatitis.

Miller, M. P. (1997) RxC program for the analysis of contingency tables (Department of Biological Sciences − Box 5640 Northern Arizona University, 1997). Retrieved from: http://www.marksgeneticsoftware.net/rxc.htm.

Borovykov, V. (2003) Statistica. Iskusstvo analiza dannykh na komp´yutere. Dlya professionalov [Statistica. Art data analysis on the computer. For professionals]. Saint Petesburg: Piter. [in Russian].

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How to Cite

1.
Slaba ОМ, Minko LY, Sichkoriz KA, Kiselyk ІО. Assessment of liver fibrosis stage influence on clinical course of periodontal diseases in patients with chronic hepatitis C. Zaporozhye Medical Journal [Internet]. 2017Jul.3 [cited 2024Nov.23];(4). Available from: http://zmj.zsmu.edu.ua/article/view/104914

Issue

No. 4 (2017)

Section

Original research

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