The state of bone and mineral metabolism in underweight pregnant women L. P. Shelestova
DOI:
https://doi.org/10.14739/2310-1210.2017.4.105116Keywords:
body weight, pregnancy, bone density, densitometryAbstract
In the available literature there are various data about changes in calcium-phosphorus and bone metabolism during pregnancy.
The aim of the research – to study the state of bone-mineral metabolism in underweight pregnant women.
Materials and methods. The research included 41 pregnant women with body weight deficiency at the beginning of pregnancy and 37 of them before labor, and also 35 pregnant women with normal body weight. The content of total calcium, nonorganic phosphorus, parathyroid hormone, osteocalcin, vitamin D total (25(OH)D) were defined in blood serum. The study of bone tissue mineral density was held with the use of ultrasound densitometry.
Results. It has been found the statistically considerable decreasing of total calcium content in the underweight pregnant women pregnant in comparison with women who have normal body weight at the beginning of pregnancy – 2.25 (2.21; 2.32) against 2.34 (2.36; 2.41) mmol/l, P = 0.001 and before labor – 2.20 (2.07; 2.30) against 2.27 (2.23; 2.35) mmol/l, P = 0.003), phosphorus (1.18 (1.12; 1.24) against 1.21 (1.17; 1.29) mmol/l, P = 0.024 and 1.16 (1.08; 1.21) against 1.20 (1.14; 1.25) mmol/l, P = 0.027), parathyroid hormone (19.4 (14.9; 28.9) against 34.5 (30.8; 38.6) pg/ml, P < 0.001 and 14.8 (13.5; 24.4) against 30.5 (18.1; 34.3) pg/ml, P < 0.001), osteocalcin (13.8 (9.3; 18.2) against 21.2 (15.4; 23.8) ng/ml, P < 0.001 and 12.3 (8.8; 16.9) against 18.3 (15.2; 20.3) ng/ml, P < 0.001), vitamin D (27.1 (24.1; 30.0) against 29.9 (27.8; 33.3) ng/ml, P = 0.004 and 23.8 (20.5; 27.8) against 28.0 (25.8; 29.9) ng/ml, P < 0.001). At the beginning of pregnancy 36.6 % women with body weight deficiency and 5.7% women with normal body weight (P = 0.003) had signs of osteopenic syndrome, before labor their amount increased up to 51.4 and 11.4 % (P < 0.001) respectively.
Conclusions. The gestation in underweight women develops with affection of bone and mineral metabolism, as evidenced by the statistically considerable decrease of calcium-phosphorus indexes and bone tissue markers and the existence of osteopenic syndrome signs. Aggravation of these changes takes place before delivery.
References
Grigor'eva, D. V. (2008) Narusheniya kostno-mineral'nogo obmena i ikh korrekciya u beremennykh s osteopeniej (Avtoref. dis… kand. med. nauk) [Disorders of bone and mineral metabolism and their correction with pregnant women with osteopenia]. (Extended abstract of candidate’s thesis). Moscow [in Russian].
Sudakov, D. S. (2011) Ocenka kal'cij-fosfornogo obmena i remodelirovaniya kostnoj tkani u zhenshhin pri fiziologicheskoj beremennosti (Avtoref. dis… kand. med. nauk) [Assessment of calcium phosphorus metabolism and bone remodeling with women with physiological pregnancy]. (Extended abstract of candidate’s thesis). Saint Petersburg. [in Russian].
Demina, E. B. (2006) Sostoyanie kostno-mineral'nogo metabolizma u beremennykh s osteopenicheskim sindromom massy (Avtoref. dis… kand. med. nauk) [The state of bone mineral metabolism with pregnant women with osteopenic weight syndrome]. (Extended abstract of candidate’s thesis). Moscow. [in Russian].
Cacua, Sh. R. & D'yakonova, A. A. (2009) Kostnyj obmen u zhenshhin s privychnym nevynashivaniem beremennosti [Bone metabolism in women with habitual miscarriage]. Antibiotiki i khimioterapiya, 54, 3 4, 82–84. [in Russian].
Stepanova, R. N. Korneeva, N. N. & Tarasova, L. P. (2011) Vzaimosvjaz' suboptimal'nykh materinskikh i perinatal'nykh iskhodov s indeksom massy tela (IMT) materi nakanune beremennosti [Interrelation of suboptimal maternal and perinatal outcomes with the body weight index (BMI) of the mother on the eve of pregnancy]. Mat' i ditya. Proceedings of the XII All-Russian Scientific Forum, (P. 201). Moscow [in Russian].
Møller, U. K., Streym, S., Mosekilde, L., Heickendorff, L., Flyvbjerg, A., Frystyk, J., et al. (2013) Changes in calcitropic hormones, bone markers and insulin-like growth factor I (IGF-I) during pregnancy and postpartum: a controlled cohort study. Osteoporos Int., 24(4), 1307 20. doi: 10.1007/s00198-012-2062-2.
Bialo, S. R. & Gordon, C. M. (2014) Underweight, overweight, and pediatric bone fragility: impact and management. Curr. Osteoporos. Rep., 12(3), 319–328. doi: 10.1007/s11914 014 0226 z.
Price, C. T., Langford, J. R. & Liporace, F. A. (2012) Essential nutrients for bone health and a review of their availability in the average North American diet. Open Orthop. J., 6, 143 9. doi: 10.2174/1874325001206010143.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
