The association of interleukin-6 gene with obesity in patients with coronary artery disease
DOI:
https://doi.org/10.14739/2310-1210.2017.5.110084Keywords:
myocardial ischemia, obesity, interleukin-6 geneAbstract
The aim of this study was to estimate value of a polymorphic locus C-174G of interleukin-6 gene in obesity development in patients with coronary artery disease.
Materials and methods. 222 patients with coronary artery disease and obesity were included in this study. The research of an allelic C-174G polymorphism of interleukin-6 gene was conducted by PCR method with electrophoretic detection of results with use of reactants SNP-EKSPRESS ("Sintol", Russian Federation).
Results. Development of obesity in patients with coronary artery disease has been connected with G gene (odds ratio = 1.58, 95 % confidence interval = [1.12–2.24], χ2 = 6.9; р < 0.05) and G/G genotype (odd ratio = 1.98, 95 % confidence interval = [1.25–3.16], χ2 = 8.4; р < 0.05) polymorphic locus of C-174G of interleukin-6 gene. The genotype G/G was reliably more frequent in patients with coronary artery disease and stage III of obesity by 15.26 % and 8.45 %, than in patients with the accompanying I and II stages of obesity (р < 0.05). In it's turn, C/G genotype in patients with coronary artery disease and the III stage of obesity occurred 11.21 % less, than in patients with the I stages of obesity (р < 0.05). Allele C, G and genotype C/C had unreliable distribution in patients with coronary artery disease depending on obesity degree (р < 0.05).
Conclusions. This study has shown that the allele of G and G/G genotype of polymorphic locus C-174G of interleukin-6 gene is associated with development and progression of obesity in patients with coronary artery disease.
References
Shilov, S. N. (2011). Khronicheskaya serdechnaya nedostatochnost´ pri ishemicheskoj bolezni serdca: klinikogeneticheskie mekhanizmy razvitiya i vozmozhnosti uluchsheniya rannej diagnostiki, profilaktiki i medikamentoznoj terapii (Avtoref. dis… dokt. med. nauk) [Chronic heart failure at coronary heart disease: klinikal and genetic mechanisms of development and possibility of improvement of early diagnostics, prophylaxis and medicamental therapie]. Dr. med. sci. diss.]. Tomsk: TomskMU [in Russian].
Kazemi, E., Jamialahmadi, K., Avan, A., Mirhafez, S. R., Mohiti, J., Pirhoushiaran, M., et al. (2017). Association of tumor necrosis factor-α -308 G/A gene polymorphism with coronary artery diseases: An evidence-based study. J Clin Lab Anal. doi: 10.1002/jcla.22153.
Spinarovа, L., Spinar, J., Vasku, A., Pávková-Goldbergová, M., Ludka, O., Tomandl, J., & Vítovec, J. (2008). Genetics of humoral and cytokine activation in heart failure and its importance for risk stratification of patients. Exp. Mol. Pathol., 84(3), 251–225. doi: 10.1016/j.yexmp.2008.03.002.
Wang, K., Dong, P. S., Zhang, H. F., Li, Z. J., Yang, X. M., & Liu, H. (2015). Role of interleukin-6 gene polymorphisms in the risk of coronary artery disease. Genet Molec Res. 14(2), 3177–3183. doi: 10.4238/2015.
Ghazouani, L., Abboud, N., Ben Hadj Khalifa, S., Added, F., Ben Khalfallah, A., Nsiri, B., et al. (2011). -174 G>C interleukin-6 gene polymorphism in Tunisian patients with coronary artery disease. Ann Saudi Med., 31, 40–44. doi: 10.4103/0256-4947.75777.
Tong, Z., Li, Q., Zhang, J., Wei, Y., Miao, G., & Yang, X. (2013). Association between interleukin 6 and interleukin 16 gene polymorphisms and coronary heart disease risk in a Chinese population. J Int Med Res., 41, 1049–1056. doi: 10.1177/0300060513483405.
Fernandez-Real, J. M., & Ricart, W. (2003). Insulin resistance and chronic сardiovascular inflammatory syndrome. Endocrine Rev., 24, 278–301. doi: 10,1210/er.2002-0010.
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., et al. (2014). Heart disease and stroke statistics—2014 update: a report from the American Heart Association. Circulation, 129, e280–e292. doi: 10.1161/01.cir.0000441139.02102.80.
Kubaszek, A., Pihlajamäki, J., Punnonen, K., Karhapää, P., Vauhkonen, & I., Laakso, M. (2003). The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes, 52, 558–561. https://doi.org/10.2337/diabetes.52.2.558.
Vozarova, B., Fernández-Real, J. M., Knowler, W. C., Gallart, L., Hanson, R. L., Gruber, J. D., et al. (2003). The interleukin-6 (-174) G/C promoter polymorphism is associated with type-2 diabetes mellitus in Native Americans and Caucasians. Hum Genet, 112, 409–413. doi: 10.1007/s00439-003-0912-x.
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)