The influence of obesity and insulin resistance on the progress of bronchial asthma

Authors

  • G. V. Yeryomenko Kharkiv National Medical University, Ukraine.,

DOI:

https://doi.org/10.14739/2310-1210.2017.5.110091

Keywords:

asthma, obesity, inflammation, insulin resistance

Abstract

Objective – to evaluate the clinical and laboratory parameters in patients with bronchial asthma and obesity based on the distribution of adipose tissue

Materials and мethods. The study involved 78 patients with uncontrolled bronchial asthma with obesity (A + O). 2 groups were formed: Group 1 – 43 patients with gynoid type obesity and Group 2 – 35 patients with android type obesity. An anthropometric study: the hip circumference (HC), waist circumference (WC), the ratio of WC/HC, case history data analysis, Asthma Control Test (ACT). Blood glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low density lipoprotein (LDL), glycated hemoglobin test (HbAlc %), index HOMA-IR Monocyte Chemoattractant Protein-1 (MCP-1), respiratory function (RF) were examined.

Results. It has been revealed the reliable increase in indices in the 2nd group: HbAlc, HOMA-IR, TG, LDL, MCP-1 p < 0.05. It has been found the decreased levels of speed indices parameters – FEV1, FEF25, FEF75 and FVC, p < 0.05. It has been found a high correlation between age and the ratio of OT/OS (r = 0.52, p < 0.05). The positive correlation between the mean force MCP-1 and TG (r = 0.56, p < 0.05) and MCP-1 and LDL (r = 0.49, p < 0.05) has been obtained. Correlation analysis of FDD and biochemical parameters: blood glucose (r = 0.26, p < 0.05), TG (r = 0.27, p < 0.051), the index NOMA-IR (r = 0.38, p <0.05), ACT (r = 0.33, p <0.05), MPC-1 (0.62, p < 0.05).

Conclusions. The obtained data proves the negative impact of android type obesity on bronchial asthma course. Identified correlations between the EF and studied biochemical indicators demonstrate the carbohydrate and fat metabolism disturbances and inflammation development in patients with different types of obesity.

References

Fomina, D. S., Goryachkina, L. A., Alekseeva, Yu. G., & Bobrikova, E. N. (2014). Bronkhial'naya astma i ozhirenie: poisk terapevticheskikh modelej [Bronchial asthma and obesity: search for therapeutic models]. Pul´monologiya, 6, 94–100 [in Russian]. doi: http://dx.doi.org/10.18093/0869-0189-2014-0-6-94-102.

Mel´nichenko, G. A. (2001) Ozhirenie i insulinorezistentnost' faktory riska i sostavnaya chast' metabolicheskogo sindroma [Obesity and insulin resistance factors of risk and component part of metabolic syndrome]. Terapevticheskij arkhiv, 73(12), 5–8 [in Russian].

Nakaz MOZ Ukraiiny «Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy pry bronkhial'nii astmi» vid 08.10.2013 r. №868 [Report of Ministry of Public Health of Ukraine About statement and adoption of medical-technologic documents of standardization of medical aid in bronchial asthma from Oktober 8, 2013, №868]. [in Ukranian].

Al-Daghri, N. M., Al-Attas, O. S., Bindahman, L. S., Alokail, M. S., Alkharfy, K. M., Draz, H. M., et al. (2012). Soluble CD163 Is Associated With Body Mass Index And Blood Pressure In Hypertensive Obese Saudi Patients. European Journal of Clinical Investigation, 42, 1221–1226. doi: 10.1111/j.1365-2362.2012.02714.x.

Price, D., Fletcher, M. & van der Molen, T. (2014). Asthma Control And Management In 8,000 European Patients: The Recognise Asthma And Link To Symptoms And Experience (REALISE) Survey. npj Primary Care Respiratory Medicine, 24,. 14009. doi: 10.1038/npjpcrm.2014.9.

Boulet, L. (2012). Asthma And Obesity. Clinical & Experimental Allergy, 43(1), 8–21.

Dixon, A. E. & Poynter, M. E. (2016). Mechanisms Of Asthma In Obesity. Pleiotropic Aspects Of Obesity Produce Distinct Asthma Phenotypes. American Journal of Respiratory Cell and Molecular Biology, 54(5), 601–608. doi: 10.1165/rcmb.2016-0017PS.

Mohammadreza, B., Farzad, H., Davoud, K. & Fereidoun Prof, A. F. (2012). Prognostic Significance Of The Complex "Visceral Adiposity Index" Vs. Simple Anthropometric Measures: Tehran Lipid And Glucose Study. Cardiovascular Diabetology, 11, 11–20. doi: 10.1186/1475-2840-11-20.

Geetha, L., Deepa, M., Anjana, R. M., & Mohan, V. (2011). Prevalence And Clinical Profile Of Metabolic Obesity And Phenotypic Obesity In Asian Indians. Journal of Diabetes Science and Technology, 5(2), 439–446. doi: 10.1177/193229681100500235.

Chen, Y. C., Dong, G. H., Lin, K. C. & Lee, Y. L. (2012). Gender Difference Of Childhood Overweight And Obesity In Predicting The Risk Of Incident Asthma: A Systematic Review And Meta-Analysis. Obesity Reviews, 14(3), 222–231. doi: 10.1111/j.1467-789X.2012.01055.x.

Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I. et al. (2015). Global, Regional, And National Incidence, Prevalence, And Years Lived With Disability For 301 Acute And Chronic Diseases And Injuries In 188 Countries, 1990–2013: A Systematic Analysis For The Global Burden Of Disease Study 2013. The Lancet, 386, 743–800. doi: 10.1016/S0140-6736(15)60692-4.

Muc, M., Mota-Pinto, A. & Padez, C. (2016). Association Between Obesity And Asthma – Epidemiology, Pathophysiology And Clinical Profile. Nutrition Research Reviews, 29(12), 1–8. doi: 10.1017/S0954422416000111.

Downloads

How to Cite

1.
Yeryomenko GV. The influence of obesity and insulin resistance on the progress of bronchial asthma. Zaporozhye Medical Journal [Internet]. 2017Oct.17 [cited 2024Dec.27];(5). Available from: http://zmj.zsmu.edu.ua/article/view/110091

Issue

No. 5 (2017)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)