The mathematical pathogenetic factors analysis of acute inflammatory diseases development of bronchopulmonary system among infants

Authors

  • G. O. Lezhenko Zaporizhzhia State Medical University, Ukraine, https://orcid.org/0000-0003-0851-4586
  • О. Ye. Pashkova Zaporizhzhia State Medical University, Ukraine,
  • V. N. Shvets Zaporizhzhia State Medical University, Ukraine,
  • H. V. Kraynya Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2017.5.110161

Keywords:

pulmonary inflammation, infants, statistical factor analysis, disease clustering

Abstract

The purpose. To study the factor structure and to establish the associative interaction of pathogenetic links of acute diseases development of the bronchopulmonary system in infants.Materials and methods. The examination group consisted of 59 infants (average age 13.8 ± 1.4 months) sick with acute inflammatory bronchopulmonary diseases. Also we tested the level of 25-hydroxyvitamin D (25(ОН)D), vitamin D-binding protein, hBPI, cathelicidin LL-37, ß1-defensins, lactoferrin in blood serum with the help of immunoenzymometric analysis. Selection of prognostically important pathogenetic factors of acute bronchopulmonary disease among infants was conducted using ROC-analysis. The procedure for classifying objects was carried out using Hierarchical Cluster Analysis by the method of Centroid-based clustering.

Results. Based on the results of the ROC-analysis were selected 15 potential predictors of the development of acute inflammatory diseases of the bronchopulmonary system among infants. The factor analysis made it possible to determine the 6 main components . The biggest influence in the development of the disease was made by "the anemia factor", "the factor of inflammation", "the maternal factor", "the vitamin D supply factor", "the immune factor" and "the phosphorus-calcium exchange factor” with a factor load of more than 0.6. The performed procedure of hierarchical cluster analysis confirmed the initial role of immuno-inflammatory components.

The conclusions. The highlighted factors allowed to define a group of parameters, that must be influenced to achieve a maximum effect in carrying out preventive and therapeutic measures. First of all, it is necessary to influence the "the anemia factor" and "the calcium exchange factor", as well as the "the vitamin D supply factor". In other words, to correct vitamin D deficiency and carry out measures aimed at preventing the development of anemia. The prevention and treatment of the pathological course of pregnancy will help stabilize the "the maternal factor" in the future.

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1.
Lezhenko GO, Pashkova ОY, Shvets VN, Kraynya HV. The mathematical pathogenetic factors analysis of acute inflammatory diseases development of bronchopulmonary system among infants. Zaporozhye medical journal [Internet]. 2017Oct.17 [cited 2024Feb.24];(5). Available from: http://zmj.zsmu.edu.ua/article/view/110161

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