Impact of the obstructive sleep apnea syndrome on left ventricular remodeling among people with different body weight

Authors

  • Yа. O. Andreieva SI “Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”,
  • O. I. Tokarenko SI “Zaporizhzhia Medical Academy of Post-Graduate Education Ministry of Health of Ukraine”,

DOI:

https://doi.org/10.14739/2310-1210.2017.6.114434

Keywords:

obstructive sleep apnea syndrome, left ventricular hypertrophy, cardiac remodeling, ventricular, obesity

Abstract

The aim of the study: to estimate the structural changes of LV among people with unrecognized OSAS and different body weight.

Materials and methods. The study involved 74 patients with OSAS. All subjects were divided into two groups: with obesity and with normal body weight. Patients with hypertension, diabetes mellitus or any other known cardiac and renal diseases, with central sleep apnea were excluded from the study. 20 healthy people were included in the control group. Each patient underwent a clinical evaluation, 24-hour ambulatory blood pressure monitoring, cardiorespiratory monitoring, transthoracic echocardiography. Pearson correlation analysis, univariate and multivariate regression analysis were performed.

Results: Ten patients from all enrolled subjects were diagnosed with LV hypertrophy. Estimated LVM and LVMI increased in group I in comparison with the group II and control group. Significant differences between group II and control group concerning LVMI and LVM weren`t admitted. A significant difference for PWTd and IVSd were observed in group I and group II, compare to control group. The LVMI was positive ly correlated with DI even after adjustment for the BMI. The LVM correlate with mean SaO2 and the lowest SaO2. The univariate regression analysis showed that the lowest SaO2, DI, AHI were associated with LVMI.

Conclusions. OSAS and obesity are associated with high LVM, LVMI and prevalence of concentric LV remodeling. The LVMI was increased parallel to an increasing in the OSAS severity in patients with obesity. There were admitted statistically significant differences for PWTd and IVSd among patients with OSAS without obesity and healthy people. Concerning LVMI and LVM, no statistically significant differences were admitted. The lowest SaO2 and DI were associated with changes of LVMI, LVM, PWTd and IVSd according to the results of regression analysis.

References

Maeder, M., Schoch, O., & Rickli, H. (2016). A clinical approach to obstructive sleep apnea as a risk factor for cardiovascular disease. Vascular Health and Risk Management, 12, 85–103. doi: 10.2147/VHRM.S74703.

Cioffi, G., Russo, T., Stefenelli, C., Selmi, A., Furlanello, F., Cramariuc, D., et al. (2010). Severe obstructive sleep apnea elicits concentric left ventricular geometry. Journal of Hypertension, 28(5), 1074–1082.

Wang, J., Zhang, H., Wu, C., Han, J., Guo, Z., Jia, C., et al. (2015). Correlation of Left Ventricular Diastolic Function and Left Ventricular Geometry in Patients with Obstructive Sleep Apnoea Syndrome. West Indian Medical Journal. West Indian Med J., 64(2), 92–98. doi: 10.7727/wimj.2014.054.

Mansukhani, M., Kolla, B., & Ramar, K. (2014). International Classification of Sleep Disorders 2 and American Academy of Sleep Medicine Practice Parameters for Central Sleep Apnea. Sleep Medicine Clinics, 9(1), 1–11. doi: http://dx.doi.org/10.1016/j.jsmc.2013.10.006.

(2016) Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of, Cardiovascular Imaging. European Heart Journal – Cardiovascular Imaging, 17(4), 412–412. doi: 10.1093/ehjci/jew041.

Korcarz, C., Peppard, P., Young, T., Chapman, C., Hla, K., Barnet, J., et al. (2016). Effects of Obstructive Sleep Apnea and Obesity on Cardiac Remodeling: The Wisconsin Sleep Cohort Study. Sleep, 39(6), 1187–1195. doi: 10.5665/sleep.5828.

Sezavar, S., Hajsadeghi, S., Hejrati, M., & Bandi, G. F. (2016) Left Ventricular Mass Index and Pulmonary Artery Pressure in Patients with the Obstructive Sleep Apnea Syndrome. J Tehran Heart Cent., 11(1), 11–14.

Downloads

How to Cite

1.
Andreieva YO, Tokarenko OI. Impact of the obstructive sleep apnea syndrome on left ventricular remodeling among people with different body weight. Zaporozhye Medical Journal [Internet]. 2017Nov.15 [cited 2024Nov.25];(6). Available from: http://zmj.zsmu.edu.ua/article/view/114434

Issue

No. 6 (2017)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)