Gender characteristics of carbohydrate and lipid metabolism and vaspin levels in hypertensive patients with obesity
DOI:
https://doi.org/10.14739/2310-1210.2017.6.114501Keywords:
obesity, hypertension, gender, insulin resistance, lipid metabolism, adipokines, vaspinAbstract
The aim of this study is to analyze gender features of patients with arterial hypertension (AH) associated with obesity and to investigate their interaction with the indicators of carbohydrate and lipid metabolism and vaspin levels.
Materials and methods. 72 patients with AH were selected for the study. In dependence to the presence of obesity, the patients were divided into 3 groups. The 1st group with AH included 32 patients without obesity. Among them there were 19 (59.4 %) women and 13 (40.6 %) men. The 2nd group consisted of 40 patients with overweight and obesity. Among them there were 17 (42.5 %) women and 23 (57.5 %) men. The 3rd (control) group consisted of 16 healthy individuals aged from 28 to 41 years old. Among them there were 10 (62.5 %) women and 6 (37.5 %) men. All the examined patients underwent anthropometric measurements, blood pressure levels, blood levels of insulin, glucose, blood lipid levels, serum vaspin concentrations, insulin resistance (IR) index.
Results. Gender differences in vaspin levels and the degree of IR have been found only in males of both study groups. In this case, these parameters significantly correlated with anthropometric indices and insulin levels in men.
Conclusions. The study showed that the increase of the studied parameters of carbohydrate and lipid metabolism and vaspin levels was observed in men and women with hypertension associated with obesity and without it. However, gender differences were found in vaspin levels and the IR degree only in males of both study groups. The parameters of vaspin and IR significantly correlated with anthropometric indices and HOMA – IR in men. Perhaps, gender characteristics should be taken into account in the treatment tactics choice of patients with hypertension and obesity.
References
Belovol, A. N., Shkol´nik, V. V., Fadeenko, G. D., & Tveretinov, A. B. (2013) Gipertonicheskaya bolezn´ i ozhirenie [Hypertensive and obesity]. Ternopil: TGMU. [in Russian].
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016). Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. Endocrine Reviews, 37(3), 278–316. doi: 10.1210/er.2015-1137.
Baker, N. A., Muir, L. A., Washabaugh, A. R., Neeley, C. K., Chen, S. Y., Flesher, C. G., et al. (2017). Diabetes-Specific Regulation of Adipocyte Metabolism by the Adipose Tissue Extracellular Matrix. J Clin Endocrinol Metab, 102(3), 1032–1043. doi: 10.1210/jc.2016-2915.
De Simone, G., Wang, W., Best, L. G., Yeh, F., Izzo, R., Mancusi, C., et al. (2017). Target organ damage and incident type 2 diabetes mellitus: the Strong Heart Study. Cardiovascular Diabetology, 16(1), 64. doi: 10.1186/s12933-017-0542-6.
Klöting, N., Kovacs, P., Kern, M., Heiker, J. T., Fasshauer, M., Schön, M. R., et al. (2011). Central vaspin administration acutely reduces food intake and has sustained blood glucose-lowering effects. Diabetologia, 54(7), 1819–1823. doi: 10.1007/s00125-011-2137-1.
(2012) Unifikovanyi klinichnyi protokol medychnoi dopomohy pry arterialnii hipertenzii. Nakaz MOZ Ukrainy №384 vid 24.05.2012 "Pro zatverdzhennia ta vprovadzhennia medyko-tekhnolohichnykh dokumentiv zi standartyzatsii medychnoi dopomohy pry arterialnii hipertenzii" [Unified clinical protocols of medical care in hypertension MOH Ukraine №384 from May, 24, 2012 "On approval and introduction of medical and technological documents for standardization of medical care in hypertension] Retrieved from: moz.gov.ua >ua/portal/dn_20120524_384.html. [in Ukrainian].
Kulikov, V. A. (2012). Fremingemskoe issledovanie serdca: 65 let izucheniya ateroskleroza [Fremingham Heart Study: 65 years of atherosclerosis]. Vestnik Vitebskogo gosudarstvennogo medicinskogo universiteta, 11(2), 16–24. [in Russian].
Gorshunska, M. Y. (2015). Vaspín u khvorykh na tsukrovyi díabet 2 typu [Vaspin in patients with type 2 diabetes mellitus]. Problemy endokrynnoi patolohii, 3, 24–31. [in Ukrainian].
Vergazova, A. N., Ruyatkina, L. A., & Ruyatkin, D. S. (2015) Gendernye kharakteristiki insulinorezistentnosti i leptinorezistentnosti pri sakharnom diabete 2 tipa. [Gender characteristics of insulin resistance and leptin resistance in type 2 diabetes mellitus]. Saharnyiy diabet v XXI veke – vremya ob'edineniya usilij. Abstracts of Papers of the VII All-Russian Diabetes Congress. (P. 53). Moscow. [in Russian].
Lezhenko, G. A. (2012). Gormonal'nyye markery formirovaniya arterial'noj gipertonii u podrostkov s ozhireniem [Hormonal markers forming arterial hypertension in adolescents with obesity]. Prakticheskaya medicina, 9(65), 129–132. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
