Gender characteristics of carbohydrate and lipid metabolism and vaspin levels in hypertensive patients with obesity
DOI:
https://doi.org/10.14739/2310-1210.2017.6.114501Keywords:
obesity, hypertension, gender, insulin resistance, lipid metabolism, adipokines, vaspinAbstract
The aim of this study is to analyze gender features of patients with arterial hypertension (AH) associated with obesity and to investigate their interaction with the indicators of carbohydrate and lipid metabolism and vaspin levels.
Materials and methods. 72 patients with AH were selected for the study. In dependence to the presence of obesity, the patients were divided into 3 groups. The 1st group with AH included 32 patients without obesity. Among them there were 19 (59.4 %) women and 13 (40.6 %) men. The 2nd group consisted of 40 patients with overweight and obesity. Among them there were 17 (42.5 %) women and 23 (57.5 %) men. The 3rd (control) group consisted of 16 healthy individuals aged from 28 to 41 years old. Among them there were 10 (62.5 %) women and 6 (37.5 %) men. All the examined patients underwent anthropometric measurements, blood pressure levels, blood levels of insulin, glucose, blood lipid levels, serum vaspin concentrations, insulin resistance (IR) index.
Results. Gender differences in vaspin levels and the degree of IR have been found only in males of both study groups. In this case, these parameters significantly correlated with anthropometric indices and insulin levels in men.
Conclusions. The study showed that the increase of the studied parameters of carbohydrate and lipid metabolism and vaspin levels was observed in men and women with hypertension associated with obesity and without it. However, gender differences were found in vaspin levels and the IR degree only in males of both study groups. The parameters of vaspin and IR significantly correlated with anthropometric indices and HOMA – IR in men. Perhaps, gender characteristics should be taken into account in the treatment tactics choice of patients with hypertension and obesity.
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