Characteristic of cellular immunity in children with recurrent respiratory diseases, depending on the level of immunoglobulin E production

Authors

  • Т. Ye. Shumna Zaporizhzhia State Medical University, Ukraine,
  • S. M. Nedelska Zaporizhzhia State Medical University, Ukraine,
  • S. V. Solovieva Zaporizhzhia State Medical University, Ukraine,
  • V. I. Masur Zaporizhzhia State Medical University, Ukraine,
  • O. Ya. Kolesnik Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2017.6.115013

Keywords:

cellular immunity, recurrency, respiratory tract infections, immunoglobulin E, children

Abstract

Purpose. To analyze the indices of cellular immunity in children with recurrent respiratory diseases, depending on the level of IgE production.

Materials and Methods. The study of cellular immunity and the level of IgE production in 81 children with recurrent respiratory diseases, aged from 2 to 6 years old (I group – 45 children with IgE index above the reference values of the age norm; II group - 36 children with normal IgE level).

Results. In 55.56 % of children with recurrent respiratory diseases, the IgE level has exceeded the reference values of the age norm. Cellular immunity in 53.33 % of children with recurrent respiratory diseases and high IgE levels was significantly more often characterized by decrease in the relative amount of CD3+, CD4+ T-lymphocytes phenotype and increase in the relative values of CD25+ lymphocytes phenotype with a moderate positive direct correlation between CD25+ lymphocytes and IgE levels (R = 0.35, p < 0.05). In children with recurrent respiratory diseases and normal IgE levels the relative amount of СD3+, CD4+, CD8+ lymphocytes phenotype was decreased and increased CD16+, CD19+ phenotypes in 38.89 %, and increase in the relative values of CD25+ lymphocytes phenotype in 11.1 %. Regardless of the ability to IgE production the cellular immunity parameters within the age standard were recorded in 53.09 % of the examined children and violation of the cellular immunity was observed in 46.91 % of cases.

Conclusions. In children with recurrent respiratory diseases changes in the cellular immunity were registered 14.44 % more often in the group of children with high IgE level.

References

Abelevich, M. M., Ivanova, E. L., & Lukushkina, E. F. (2008) Izuchenie e´ffektivnosti i bezopasnosti immunokorregiruyushchej terapii izoprinozinom u detej s oslozhnennym techeniem allergicheskikh zabolevanij [A study of the efficacy and safety of immunocorrective therapy with isoprinosine in children with a complicated course of allergic diseases]. Farmateka, 1, 71–76. [in Russian].

Marusyk, U. I. (2016) Osoblyvosti klitynnoi lanky imunnoi vidpovidi shkoliariv, khvorykh na bronkhialnu astmu rannoho pochatku, zalezhno vid atsetyliatornoho polimorfizmu [Features of the cellular link of the immune response of schoolchildren, patients with bronchial asthma of early onset, depending on acetylator polymorphism]. Dytiachyi likar, 1(46), 55–56. [in Ukrainian].

Depner, M., Ege, M. J., Cox, M. J., Dwyer, S., Walker, A. W., Birzele, L. T., et al. (2017) Bacterial microbiota of the upper respiratory tract and childhood asthma. The Journal of Allergy and Clinical immunology, 3(139), 826–834. doi: 10.1016/j.jaci.2016.05.050.

Razi, C. H., Harmanci, K., Abaci, A., Özdemir, O., Hizli, S., Renda R., & Keskin, F. (2010) The immunostimulant OM-85 BV prevents wheezing attacks in preschool children. J. Allergy ClinImmunol, 126(4), 763–769. doi: 10.1016/j.jaci.2010.07.038.

Tangye, S. G., Pillay, B., Randall, K. L., Avery, D. T., Phan, T. G., Gray, P., et al.

(2017) Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells. The Journal of Allergy and Clinical immunology, 139(3), 933–949. doi: 10.1016/j.jaci.2016.07.016.

Volosovets, O. P., Dosenko, V. E., Kryvopustov, S. P., & Pavlyk E. V. (2015) Znachennia odnonukleotydnykh polimorfizmiv v henakh MTOR ta ATG5 vrozvytku alerhichnykh zakhvoriuvan u ditei [The importance of single nucleotide polymorphisms in the MTOR and ATG5 genes in the development of allergic diseases in children]. Zdorov´e rebenka, 3(63), 5–11. [in Ukrainian].

Migacheva, N. B., Kaganova, T. I., & Aronova, A. V. (2013) Osobennosti techeniya ostrykh respiratornykh infekcij u detej s allergicheskimi boleznyami: problemy vedeniya pacientov i puti ikh resheniya [Special Features of Acute Respiratory Infections Clinical Course in Children with Allergic Disorders: Problems of Management and Ways to Solve Them]. Voprosy sovremennoj pediatrii, 2, 78–82. [in Russian].

Galli, S. J., & Tsai, M. (2012) IgE and mast cells in allergic disease. Nat Med, 18(5), 693–704. doi: 10.1038/nm.2755.

Lawren, C. Wu, & Ali A. Zarrin. (2014) The production and regulation of IgE by the immune system. Nature Reviews Immunology, 14, 247–259. doi: 10.1038/nri3632.

Rebrova, O. Yu. (2006) Statisticheskij analiz medicinskikh dannykh. Primenenie paketa prikladnykh programm STATISTICA [Statistical analysis of medical data. Application of the STATISTICA software package]. Moscow: Medya Sfera. [in Russian].

Downloads

How to Cite

1.
Shumna ТY, Nedelska SM, Solovieva SV, Masur VI, Kolesnik OY. Characteristic of cellular immunity in children with recurrent respiratory diseases, depending on the level of immunoglobulin E production. Zaporozhye Medical Journal [Internet]. 2017Nov.15 [cited 2024Jul.23];(6). Available from: http://zmj.zsmu.edu.ua/article/view/115013

Issue

No. 6 (2017)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)