Antimicrobial effect of proteflazid extract on microflora of peri-implant areas in infectious and inflammatory complications after dental implantation

Authors

  • M. M. Ananieva Higher State Educational Institution of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava,
  • M. O. Faustova Higher State Educational Institution of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava,
  • Ya. O. Basarab Higher State Educational Institution of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava,
  • G. A. Loban’ Higher State Educational Institution of Ukraine “Ukrainian Medical Stomatological Academy”, Poltava,

DOI:

https://doi.org/10.14739/2310-1210.2017.6.115264

Keywords:

proteflazid extract, flavonoids, peri-implantitis, microbial sensitivity tests, antimicrobial agents

Abstract

The purpose of this study was to investigate the proteflazid extraction antimicrobial action onto causative agents of infectious and inflammatory diseases occurring during dental implant placement.

Materials and Methods. We studied clinical strains of Streptococcus sanguinis, Staphylococcus warneri and Kocuria kristinae, isolated from oral mucosa of patients who were diagnosed with peri-implant mucositis and peri-implantitis. The cultivation of strains was carried out by standard method. Final identification was carried out with an automatic bacteriological analyzer Viteck 2 compact bioMérieux (France) according to manufacturer's instructions. The sensitivity of derived strains to proteflazid and to 96 % ethyl alcohol assessment was done by double serial dilutions according to the standard procedure.

Results. The clinical strains of Streptococcus sanguinis, Staphylococcus warneri and Kocuria kristinae were found to be sensitive to effects of proteflazid extract. K. kristinae was proven to be the least susceptible strain. But the clinical strain of Streptococcus sanguinis was found to be the most sensitive to proteflazid extract. 96 % ethyl alcohol, which is a component of the extract, showed a bactericidal effect on the clinical strains in the study, but its minimal bactericidal concentration was significantly lower than minimal bactericidal concentration of the proteflazid extract.

Conclusions. The proteflazid extract can produce antimicrobial effect on the clinical strains of Streptococcus sanguinis, Staphylococcus warneri and Kocuria kristinae, which colonize the oral mucosa of patients with infectious and inflammatory complications following dental implant placement. Antimicrobial action of the proteflazid extract is much higher than action of 96% ethyl alcohol that confirms the direct antimicrobial action of flavonoids, which are components of the studied extract.

References

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How to Cite

1.
Ananieva MM, Faustova MO, Basarab YO, Loban’ GA. Antimicrobial effect of proteflazid extract on microflora of peri-implant areas in infectious and inflammatory complications after dental implantation. Zaporozhye Medical Journal [Internet]. 2017Nov.15 [cited 2024Nov.25];(6). Available from: http://zmj.zsmu.edu.ua/article/view/115264

Issue

No. 6 (2017)

Section

Original research

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