Dependence of carotid arteries intima-media thickness on body weight of patients with hypertension

Authors

  • V. V. Syvolap Zaporizhzhia State Medical University, Ukraine, https://orcid.org/0000-0001-9865-4325
  • V. A. Matsalaeva Zaporizhzhia State Medical University, Ukraine,
  • M. S. Potapenko Zaporizhzhia State Medical University, Ukraine,
  • I. V. Likhasenko Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.1.121605

Keywords:

essential hypertension, arterial intima, body weight

Abstract

The aim was to study the dependence of structural changes in the common carotid arteries (intima-media complex thickness and vascular diameter) on the body weight index of hypertensive patients.

Material and methods. The study included 84 patients with stage 2 essential hypertension (EH) and 15 healthy people. Groups did not differ significantly in age, gender, height. Patients with EH, depending on the body mass index, were divided into three groups: normal body weight (n = 19), overweight (n = 34) and obesity (n = 31). The study excludes patients with intima-media complex thickness (IMT) of more than 900 μm or atherosclerotic plaques presence in the common carotid arteries (CCA). All patients were measured: "office" ABP, diameter and intima-media complex thickness of the common carotid arteries, structural-geometric and functional indicators of the heart.

Results. In patients with EH there is a simultaneous remodeling of blood vessels (a significant increase in IMT of 17,8% and CCA diameter of 6,6%) and the heart (LV hypertrophy, left atrium dilation,LV end diastolic pressure increase). Hypertensive patients with overweight and obesity had significantly higher right CCA diameters by 8.1% (p = 0.016) and 6.9% (p = 0.039), respectively, than those with EH and normal body mass. The left CCA diameter was significantly higher by 8.7% (p = 0.012) in patients with overweight compared to a similar figure in patients with EH and normal body mass. Patients with normal, overweight and obesity with EH significantly did not differ according to the indicators of CCA IMT on both sides. With an increase in the body mass index in patients with EH there is a progressive increase in the left atrium diastolic size: in patients with overweight by 10.7% (p = 0.005) more than in normal body weight patients; and with obesity by 2,5% (p = 0,001) more than in overweight patients. In patients with EH and obesity the right CCA IMT correlated with age (r = 0.41; p = 0.02), EF LV (r = 0.39; p = 0.03), theLV posterior wall thickness (r = 0.37; p = 0.04), E / E '(r = 0.39; p = 0.04). In patients with EH and normal body mass the right CCA IMT correlated with the left atrium diastolic size (r = 0.51; p = 0.02), body weight (r = 0.57; p = 0.01); the left CCA IMT with body weight (r = 0.48; p = 0.04); body mass index (r = 0.61; p = 0.01) and aorta diameter (r = 0.51; p = 0; 02). In patients with EH and obesity the intima-media complex minimum thickness (604 ± 31 μm) occurred in the normal type ofLV geometry and significantly (p = 0.023) increased by almost 100 μm in eccentric hypertrophy and amounted to 703 ± 93 μm.

Conclusions. An increase in the body mass index in patients with EH is accompanied by an increase in the common carotid arteries diameter, the left atrium diastolic size, the posterior wall thickness and the left ventricular mass index. In patients with EH and normal body mass the right CCA IMT correlated with body weight (r = 0.57; p = 0.01); the left CCA IMT with body weight (r = 0.48; p = 0.04) and BMI (r = 0.61; p = 0.01). A significant increase in the intima-media complex thickness of the left CCA occurs only among obese patients with eccentric hypertrophy compared with normal left ventricular geometry.

References

Cromwell, C., Aichele, K., Oakman, J., Neal, M., Lenzo, J., Perez, A., et al. (2016). Carotid Artery IMT, Blood Pressure, and Cardiovascular Risk Factors in Males and Females. International Journal of Exercise Science, 9(4), 482–490.

Greenland, P., Abrams, J., Aurigemma, F., Bond, M., Clark, L., Criqui, M., et al. (2000). Prevention Conference V: Beyong secondary prevention identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden; Writing Group III. Circulation, 101(1), 16–22.

Pauletto, P., Palatini, P., Da Ros, S., Pagliara, V., Santipolo, N., Baccillieri, S., et al. (1999). Factors underlying the increase in carotid intima-media thickness in borderline hypertensives. Arteriosclerosis, Thrombosis, and Vascular Biology, 19(5), 1231–7. doi: 10.1161/01.ATV.19.5.1231.

Li, C., Liu, R., Wang, J., & Yang, J. (2017). Relationship between blood pressure variability and target organ damage in elderly patients. European Review for Medical and Pharmacological Sciences, 21(23), 5451–5455. doi: 10.26355/eurrev_201712_13934.

Dalmas, E., Kahn, J., Giral, P., Abdennour, M., Bouillot, J., Fellahi, S., et al. (2013). Intima-media thickness in severe obesity: links with BMI and metabolic status but not with systemic or adipose tissue inflammation. Diabetes Care, 36(11), 3793–802. doi: 10.2337/dc13-0256.

Sameeah, A., & Sarbast, A. (2015). Correlation between Carotid Artery Intima-Media Thickness and Luminal Diameter with Body Mass Index and Other Cardiovascular Risk Factors in Adults. Sultan Qaboos University Medical Journal, 15(3), e344–e350. doi: 10.18295/squmj.2015.15.03.007.

Chahal, H., Backlund, J., Cleary, P., Lachin, J., Polak, J., Lima, J., et al. (2012). Relationship between Carotid Intima-Media Thickness and Left Ventricular Mass in Type 1 Diabetes: results from the Epidemiology of Diabetes Interventions and Complications (EDIC) Study. American Journal of Cardiology, 110(10), 1534–1540. doi: 10.1016/j.amjcard.2012.07.014.

Shlyakhto, E., Conrady, A., Rudomanov, O., Zaharov, D., & Vahrameeva, N. (2004). Left ventricular remodeling, carotid intima-media thickness and endothelial fuction in untreated hypertensive patients. American Journal of Hypertension, 17(5), S86. doi.org/10.1016/j.amjhyper.2004.03.220.

Toikka, J., Laine, H., Ahotupa, M., Haapanen, A., Viikari, J., Hartiala, J., & Raitakari, O. (2000). Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension. Hypertension, 36(6), 929–33. doi: 10.1161/01.HYP.36.6.929. •

Park, H., Youn, T., Kim, H., Kim, Y., Sohn, D., Oh, B., et al. (2013). Different pattern of carotid and myocardial changes according to left ventricular geometry in hypertensive patients. Journal of Human Hypertension, 27(1), 7–12. doi: 10.1038/jhh.2011.115.

Boutouyrie, P., Laurent, S., Girerd, X., Benetos, A., Lacolley, P., Abergel, E., & Safar, M. (1995). Common carotid artery stiffness and patterns of left ventricular hypertrophy in hypertensive patients. Hypertension, 25, 651–9. doi: 10.1161/01.HYP.25.4.651.

Khutan, H., Aggarwal, S., Kajal, K., Garg, R., Kaur, R., & Kaur, A. (2017). Study of carotid intimal medial thickness in essential hypertension with or without left ventricular hypertrophy. Annals of African Medicine, 16(4), 192–195. doi: 10.4103/aam.aam_9_17.

Wang, R., Guo, Q., Yang, X., Wang, R., & Huang, S. (2011). Intima-media thickness and left ventricle remodeling in patients with prehypertension and impaired glucose tolerance. Zhonghua Xin Xue Guan Bing Za Zhi, 39(12), 1105–9.

Appelman, Y., van Rijn, B., Ten Haaf, M., Boersma, E., & Peters, S. (2015). Sex differences in cardiovascular risk factors and disease prevention. Atherosclerosis, 241(1), 211–8. doi: 10.1016/j.atherosclerosis.2015.01.027.

Sun, P., Dwyer, K., Merz, C., Sun, W., Johnson, C., Shircore, A., & Dwyer, J. (2000). Blood pressure, LDL cholesterol, and intima-media thickness: a test of the "response to injury" hypothesis of atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 20(8), 2005–10.

Simon, A., Gariepy, J., Chironi, G., Megnien, J. L., & Levenson, J. (2002). Intima-media thickness, a new tool for diagnosis and treatment of cardiovascular risk. Hypertension, 20(2), 159–69. doi: 10.1097/00004872-200202000-00001.

Downloads

How to Cite

1.
Syvolap VV, Matsalaeva VA, Potapenko MS, Likhasenko IV. Dependence of carotid arteries intima-media thickness on body weight of patients with hypertension. Zaporozhye Medical Journal [Internet]. 2018Jan.31 [cited 2024Dec.23];(1). Available from: http://zmj.zsmu.edu.ua/article/view/121605

Issue

No. 1 (2018)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)