The effect of statin therapy on oxidative stress indices in patients with arterial hypertension and type 2 diabetes mellitus
DOI:
https://doi.org/10.14739/2310-1210.2018.1.121876Keywords:
hypertension, diabetes mellitus type 2, statins, oxidative stressAbstract
Objective: to study the effect of statin therapy on the oxidative and antioxidant systems parameters in patients with arterial hypertension (AH) and concomitant type 2 diabetes mellitus (DM2T).
Materials and methods. 126 patients (55 males and 71 females, average age was 57.8 ± 6.2 years) with AH stage II and compensated DM2T were divided into 2 groups: the 1 group – with AH and DM2T (n = 69), who were constantly taking statins (rosuvastatin 10 mg/day or atorvastatin 20 mg/day) for at least 1 year; the 2 group – patients with AH and DM2T (n = 57) who did not take statins. The control group included 20 healthy volunteers. The parameters of lipid and carbohydrate metabolism, the degree of insulin resistance (HOMA-IR), the state of the oxidant system (malonic dialdehyde level –MDA), the antioxidant system (the activity of glutathione peroxidase (GPO) and the level of sulfhydryl groups -SH-groups) were evaluated. The statistics was carried out using the Statistica software package, version 8.0.
Results. In the 1st group only the levels of LDL cholesterol significantly differed from the control group (P < 0.05). In the 2nd group the levels of total cholesterol and LDL cholesterol were expected to be higher than in the 1st group (P < 0.05) and the control group (P < 0.05). Despite the higher level of fasting glucose in the 2nd group than in the 1st group, HOMA-IR in the 1st group was higher than in the 2nd group (7.48 ± 1.76 and 7.17 ± 1.54, respectively, P > 0.05). In the 1st group in comparison with the 2nd group unreliable increase in GPO and SH-groups levels on the background of the increase in MDA levels (P > 0.05) were observed.
Conclusions. The use of statins in low doses in AH combined with DM2T was accompanied by a nonsignificant improvement of antioxidant protection parameters on the background of increased insulin resistance and increased activity of lipid peroxidation.
References
Manischenkova, Yu. A., Shkala, L. V., Dudich, T. I., Litvinova, M. I., & Ivanova, M. A. (2013). Oksidantnyj stress u bol'nykh sakharnym diabetom 2-go tipa, sochetannym s obostreniem khronicheskogo pielonefrita [Oxidative Stress in Patients with Diabetes Mellitus Type 2 Associated with Exacerbation of Chronic Pyelonephritis]. Mezhdunarodnyj endokrinologicheskij zhurnal, 51(3), 19–22.
Pankratova, Yu. V. (2012) Randomizirovannoe klinicheskoe issledovanie: vliyanie metformina na markery oksidativnogo stressa i antioksidantnye rezervy u bol'nykh s vpervye vyyavlennym sakharnym diabetom 2 tipa [Randomized clinical trial: the effect of metformin on markers of oxidative stress and antioxidant reserves in patients with newly diagnosed type 2 diabetes mellitus]. Ozhirenie i metabolism, 3, 41–42.
American Diabetes Association (2016). Standards of Medical Care in Diabetes-2016. Diabetes Care, 39(1), S60–S71. doi: 10.2337/dc16-S011.
Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., et al. (2013) ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J. of Hypertension, 31(7), 1281–1357. doi: 10.1097/01.hjh.0000431740.32696.cc.
Davydova, I. V. (2012). Naznachenie statinov pacientam s arterial'noj gipertenziej: istinnye celi i dokazannye preimuschestva [Prescribing statins to patients with hypertension: true goals and proven benefits]. Zdorov'ya Ukrayiny, 2(375). Retrieved from http://health-ua.com/wp-content/uploads/2016/02/2-42.pdf [in Russian].
Nakaz Ministerstva okhorony zdorovia Ukrainy «Pro zatverdzhennia protokoliv nadannia medychnoi dopomohy patsiientam z endokrynnymy zakhvoriuvanniamy» vid 22.05.2009 roku №356 [Order of the Ministry of Health of Ukraine «On approval of protocols for the provision of medical care to the patients with endocrine diseases» from May 22, 2009 №356]. Retrieved from http://www.moz.gov.ua/ua/portal/dn_20090805_574.html [in Ukrainian].
Arutyunov, A. V., Dubinina, E. E., & Zybina, N. N. (2000). Metody ocenki svobodnoradikal'nogo okisleniya i antioksidantnoj sistemy organizma [Methods for assessing free radical oxidation and the body's antioxidant system]. Saint Petersburg: Foliant [in Russian].
Aronov, D. M. (2013). Plejotropnye e'ffekty statinov na sovremennom e'tape ikh izucheniya: fokus na atorvastatin. Chast' III. Mekhanizmy plejotropii statinov [Pleiotropic effects of statins at the present stage of their study (focus on atorvastatin). Part III. Mechanisms of the pleiotropy of statins]. Cardiosomatika, 2, 20–26 [in Russian].
Kilit, C., Koçak, F. E., & Paşalı Kilit, T. (2017). Comparison of the effects of high-dose atorvastatin and high-dose rosuvastatin on oxidative stress in patients with acute myocardial infarction: A pilot study. Turk Kardiyol Dern Ars, 45(3), 235–243 doi: 10.5543/tkda.2017.22792
Prokhorovich, E. A. (2013). Gipotenzivnaya terapiya: novaya kombinaciya i novye vozmozhnosti [Hypotensive therapy: a new combination and new possibilities]. Consilium Medicum, 15(10), 121–125 [in Russian].
Lodovici, M., Bigagli, E., Luceri, C., Mannucci, E., Rotella, C. M,, & Raimondi, L. (2015). Gender-related drug effect on several markers of oxidation stress in diabetes patients with and without complications. Eur J Pharmacol, 766, 86–90. doi: 10.1016/j.ejphar.2015.09.041.
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