Immunity peculiarities of neonates in case of perinatal pathology

Authors

  • О. S. Godovanets Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi,
  • A. B. Mihalchan Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi,
  • O. I. Godovanets Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi,
  • V. V. Bezruk Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi,
  • T. O. Bezruk Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi,

DOI:

https://doi.org/10.14739/2310-1210.2018.1.122001

Keywords:

newborns, perinatology, hypoxia, immune system

Abstract

The immune system as one of the regulating systems of the body determined peculiarities of child adaptation after birth stipulating physiology of adaptation or perinatal pathology formation.
Objective: to study peculiarities of immunological indices in case of neonates’ perinatal pathology to detect their role in pathogenesis and formation of diseases severity.
Materials and methods. The group of term infants with clinical signs of perinatal pathology (173 individuals) was examined. They were divided into two groups: group A included those with diagnosed severe forms of diseases (121 individuals), and group B included 52 infants with general moderate severity of perinatal pathology. The group of comparison included 82 newborns without substantial adaptive deviations after birth. IL1 and IL6 levels were examined by means of immunofluorescence method “Clonospectr” using the reagents produced by “ProCon”. Absolute and relative amount of СD2+-associated Т and NK-lymphocytes, СD14+-associated monocytes, СD15+-associated neutrophils, СD19+-associated В-lymphocytes and СD54+-associated ІСАМ-1 cells were determined by means of immunofluorescence method “Status” using the set of monoclonal and polyclonal antibodies produced by “Sorbent”. The data obtained were statistically processed with the application of applied programs package used for medical-biological studies “Statgraphics Centurion XVI.I” [2011] on the personal computer Pentium MMX CPU.
Results. The results obtained were indicative of considerable changes in the immune system indices in newborns under conditions of birth stress and hypoxia. It has been found that a term newborn has a special different from that of adults biologically mediated state of immune system, that can determine both the development of physiological adaptation and under certain circumstances excessive reactions of systemic inflammation, autoimmune processes and destruction of tissues. One of the evidences of immune system components participation in perinatal pathology pathogenesis is detected correlation between immune disorders severity and clinical manifestation of diseases, as well as immune indices normalization in a long-term organism adaptation formation.
Conclusions. Based on the data obtained it has been concluded that immune system status determination is reasonable for diagnostics of disadaptation syndrome severity in early neonatal period.

References

Field, C. J. (2005) The immunological components of human milk and their effect on immune development in infants. J Nutr, 135(1), 1–4.

Hanson, L. A., Korotkova, M., Lundin, S., Håversen, L., Silfverdal, S. A., Mattsby-Baltzer, I., et al. (2003) The transfer of immunity from mother to child. Annals of the New York Academy of Sciences, 987(1), 199–206. doi: 10.1111/j.1749-6632.2003.tb06049.x

Daminova, M. A., Safina, A. I., & Khamzina, G. A. (2013) Novoe v klassifikacii i diagnostike ostrogo povrezhdenijya pochek u novorozhdennyh [New in the classification and diagnosis of acute kidney injury (AKI) newborn]. Vestnik sovremennoj klinicheskoj mediciny, 6(6), 62–70. [in Russian].

Shunko, E. E., Omelchenko, L. V., Putkaradze, R. V., & Laksha, O. T. (2014) Osoblyvosti imunnoi systemy u novonarodzhenykh v krytychnomu stani, vplyv na stan zdorovia v rannomu dytynstvi [Features of the immune system in newborns in critical condition, the impact on health in early childhood]. Zbirnyk naukovykh prats spivrobitnykiv NMAPO im. P.L. Shupyka, 23(3), 395–407. [in Ukrainian].

Tonni, G., Leoncini, S., Signorini, C., Ciccoli, L., & De Felice, C. (2014) Pathology of perinatal brain damage: background andoxidative stress markers. Arch Gynecol Obstet, 290(1), 13–20. doi: 10.1007/s00404-014-3208-6.

Aversa, S., Pellegrino, S., Barberi, I., Reiter, R. J., & Gitto, E. (2012) Potential utility of melatonin as an antioxidant during pregnancy and in the perinatal period. J Matern Fetal Neonatal Med, 25(3), 207–221. doi: 10.3109/14767058.2011.573827.

Perrone, S., Tataranno, M.L., Negro, S., Longini, M., Marzocchi, B., Proietti, F., et al. (2010) Early identification of the risk for free radical-related diseases in preterm newborns. Early Hum Dev, 86(4), 241–4. doi: 10.1016/j.earlhumdev.2010.03.008.

Downloads

How to Cite

1.
Godovanets ОS, Mihalchan AB, Godovanets OI, Bezruk VV, Bezruk TO. Immunity peculiarities of neonates in case of perinatal pathology. Zaporozhye medical journal [Internet]. 2018Jan.31 [cited 2024Apr.26];(1). Available from: http://zmj.zsmu.edu.ua/article/view/122001

Issue

No. 1 (2018)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)