Efficacy of probiotic administration in the complex treatment of chronic catarrhal gingivitis in children

Authors

  • O. I. Godovanets Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine,
  • D. G. Popesku Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine,
  • O. S. Godovanets Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine,
  • V. V. Bezruk Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine,
  • T. O. Bezruk Higher State Educational Establishment of Ukraine “Bukovinian State Medical University”, Chernivtsi, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.02.125173

Keywords:

gingivitis, probiotics, children

Abstract

One of the leading pathogenic mechanisms of chronic catarrhal gingivitis development in children is disorders in the system of child macroorganism and oral cavity microorganisms interrelation as a result of normal microflora inhibition against the background of general amount of opportunistic and pathogenic microorganisms. The oral cavity protective mechanisms condition plays an important role in this process.

Due to this fact a perspective direction is to study the methods of mentioned pathology treatment using probiotics containing strains of normal microflora with high antagonistic, enzymatic and immune-modeling properties able to inhibit growth of pathogenic bacteria.

Objective: to improve the common method of catarrhal gingivitis treatment in children by means of oral microbiocenosis correction on the local level.

Materials and methods. The method of catarrhal gingivitis treatment in children with administration of the probiotic “BioGaia Prodentis” has been developed. 30 children at the age of 12 with clinical signs of chronic catarrhal gingivitis were treated and dynamically observed. The children were divided into two groups: the main (with application of the improved method) and the group of comparison (the common method was applied). The periodontal tissue condition in children was assessed on the basis of OHI-S, PMA, CPI indices, and Schiller-Pisaref test. The oral cavity local immunity was assessed by means of lysozyme activity, the level of secretory immunoglobulin A, the degree of dysbiosis by urease activity detection in the oral fluid of children.

Results. Administration of the drug “BioGaia Prodentis” in the complex of chronic catarrhal gingivitis treatment in children resulted in a quick reverse development of clinical signs. Among the children of the main group on the 3–4th day of treatment a tendency to subsidence of inflammatory signs was observed. In the group of comparison the signs such as hyperemia, swelling and bleeding regressed at the beginning of the 4–5th day. An average duration of local treatment in the main group was 4.46 ± 0.27 days against 8.00 ± 0.36 days in the group of comparison (P < 0.05). The results of paraclinical examination of children oral cavity after treatment have become the evidence of the clinical changes found. Significant difference by all the indices in children of the main group was detected.

Catamnestic examination demonstrated that in half a year in children who were treated with the medicine “BioGaia Prodentis” better clinical-paraclinical indices were registered twice as less than those in children from the comparison group.

Conclusions. Treatment of chronic catarrhal gingivitis in children with administration of the medicine “BioGaia Prodentis” in a complex therapy contributes to oral cavity microbiocenosis normalization. Clinical efficacy of the proposed method is evidenced by the local treatment periods reduction almost twice as large and approximately 2/3 decreased of the disease signs relapse as compared to the initial indices.

References

Jantszarek, M., Bachanek, T., Mazur, E., & Chałas, R. (2016). The role of probiotitss in prevention of oral diseases. Postepy Hig Med Dosw., 4, 70(0), 850–7. doi: 10.5604/17322693.1214381.

Levickij, A. P., Makarenko, O. A., & Selivanskaya, I. A. (2007) Fermentativnyij metod opredeleniya disbioza polosti rta dlya skrininga pro- i prebiotikov [Enzymatic method for determining oral dysbiosis for screening pro- and prebiotics]. Kyiv. [in Russian]

Marchenko, O. A. (2015) Kliniko-mikrobiolohichne obgruntuvannia dyferentsiiovanykh pidkhodiv do likuvannia khronichnoho heneralizovanoho kataralnoho hinhivitu u ditei shkilnoho viku (Dis…kand. med. nauk). [Clinical and microbiological substantiation of differentiated approaches to the treatment of chronic generalized catarrhal gingivitis in school-age children. Dr. med. sci. diss.]. Kyiv. [in Ukrainian]

Polischuk, T. V. (2013) Klinichna efektyvnist kompleksu pre- ta probiotyku u likuvanni khronichnoho heneralizovanoho kataralnoho hinhivitu u ditei [Microbiological effectiveness of prebiotic-probiotic complex in the therapy of generalized catarrhal]. VISNYK VDNZU «Ukrainska medychna stomatolohichna akademiia», 13(2), 52–55. [in Ukrainian]

Savchuk, N. (2013) Innovatsiini pidkhody do profilaktyky kariiesu zubiv u ditei i vahitnykh zhinok [Innovative approaches to the dental caries prevention in children and pregnant women]. Sovremennaya stomatologiya, 5, 46–50. [in Ukrainian]

Cagetti, M. G., Mastroberardino, S., Milia, E., Cocco, F., Lingström, P., & Campus, G. (2013) The use of probiotic strains in caries prevention: a systematic review. Nutrients, 5(7), 2530–50. doi: 10.3390/nu5072530.

Fernández, C.E., Giacaman, R. A., Tenuta, L. M., & Cury, J. A. (2015) Effect of the Probiotic Lactobacillus rhamnosus LB21 on the Cariogenicity of Streptococcus mutans UA159 in a Dual-Species Biofilm Model. Caries Res., 49(6), 583–90. doi: 10.1159/000439315.

Ashwin, D., Ke, V., Taranath, M., Ramagoni, N. K., Nara, A., & Sarpangala, M. (2015) Effect of Probiotic Containing Ice-cream on Salivary Mutans Streptococci Levels in Children of 6-12 Years of Age: A Randomized Controlled Double Blind Study with Six-months Follow Up. J Clin Diagn Res., 9(2), ZC06–9. doi: 10.7860/JCDR/2015/10942.5532.

Downloads

How to Cite

1.
Godovanets OI, Popesku DG, Godovanets OS, Bezruk VV, Bezruk TO. Efficacy of probiotic administration in the complex treatment of chronic catarrhal gingivitis in children. Zaporozhye medical journal [Internet]. 2018Mar.7 [cited 2024Apr.20];(2). Available from: http://zmj.zsmu.edu.ua/article/view/125173

Issue

No. 2 (2018)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)