The influence of combined antioxidants usage on periodontal pathology in women with polycystic ovarian syndrome

Authors

  • Yu. G. Romanova Odesa National Medical University, Odesa, Ukraine,
  • S. V. Dizik Odesa National Medical University, Odesa, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.02.125272

Keywords:

polycystic ovarian syndrome, periodontitis, oral liquid, biochemical markers, therapeutic and preventive complex, antioxidants

Abstract

The purpose of this work was to assess the features of biochemical markers changes in women with periodontal pathology associated with polycystic ovarian syndrome using optimal management of chronic generalized periodontitis prevention and treatment.

Materials and methods. There were examined two groups of 25 women each in the course of moderate severity chronic generalized periodontitis associated with polycystic ovarian syndrome. The control group consisted of 25 women. The treatment-and-prophylactic complex (locally – mouthwash “Biodent-4” and mucosal gel “EKSO”, orally – an amaranth oil-based drug and tablets “EKSO”) was used in the first group; only conventional treatment was used in the second group.

Results. In the first group urease activity decreased by 36.0 % after a month of treatment, in 6 months - by 46.0 %, in 12 months - by 62.4 %; lysozyme increased within 1 month by 40.5 %, in 6 months – by 52.4 %, in 12 months – by 53.6 %, diene conjugates in 1 month – by 32.0 %, in 6 months – by 43.5 %, in 12 months – by 42,8 %; malondialdehyde in 1 month by 31.7 %, in 6 months – by 43.9 %, in 12 months – by 42.6 %. Catalase increased in 1 month by 40.0 %, in 6 months – by 52.0 %, in 12 months – by 62.0 %. In the second group urease activity decreased by 12.6 % in 1 month, in 6 months – by 25.3 %, in 1 year – by 34.2 %. The level of diene conjugates decreased in 6 months by 22.3 %, in 12 months – by 24.8 %. Activity of superoxide dismutase decreased in 1 month by 20.0 %, in 6 months – by 22.6 %, in 12 months – by 27.8 %, glutathione peroxidase in 6 months – by 28.9 %, in 12 – by 26.3 %, catalase and lysozyme increased in 12 months by 36.7 and 30.5 %, respectively.

Conclusions. The oral fluid biochemical parameters dynamics in women with moderate severity chronic generalized periodontitis associated with polycystic ovarian syndrome evidences the high efficiency of the prophylactic and therapeutic complex. Positive changes in the periodontal status of patients can be explained by a decrease in the intensity of lipid peroxidation, an inflammatory response, and activation of antioxidant protection in the oral cavity.

 

References

Chumakova Yu. G., Vishnevskaja, A. A., & Ostrovskij, A. V. (2012) Sostoyanie mikrobiocenoza polosti rta u lic molodogo vozrasta s vospalitel'nymi zabolevaniyami parodonta [The state of microbiocenosis of oral cavity in young patients with inflammatory diseases of periodontium]. Visnyk stomatolohii, 3, 28–32 [in Russian].

Karpenko, I. N., Bulkina, N. V., & Ponukalina, E. V. (2009). Sovremennye predstavleniya ob e'tiologii i patogeneze bystroprogressiruyushchego parodontita. Obzor [Modern ideas about the etiology and pathogenesis of rapidly progressing periodontitis. A review]. Arkhiv patologii, 74(1), 57–60 [in Russian].

Nazarian, R., & Olshanetsky, A. (2014) Parodontolohichnyi status zhinok z syndromom polikistoznykh yaiechnykiv [Periodontal Status of Women with Polycystic Ovary Syndrome]. Visnyk problem biolohii ta medhtshny, 2, 12–16 [in Ukrainian].

Nikolskaya, V. A., & Memetova, Z. N. (2001) Rol' biokhimicheskogo analiza pri patologii stomatologicheskogo kharaktera v vyyavlenii e'ndokrinnykh zabolevanij, soprovozhdayushchikhsya giperinsulinemiej [Role of biochemical analysis at pathology of stomatological character in the exposure of endocrine diseases, attended with a hyperinsulinemia]. Uchenye zapiski Tavricheskogo nacional'nogo universiteta imeni V.I. Vernadskogo. Seriya: Biologiya, khimiya, 24, 4(63), 177–182 [in Russian].

(2012) Consensus on Women’s Health Aspects of Polycystic Ovary Syndrome. Human Reproduction, 27(1), 14–24. doi.org/10.1093/humrep/der396.

Levickij, A. P. (2007) Fiziologicheskaya mikrobnaya sistema polosti rta [Physiological microbial system of the oral cavity]. Visnyk stomatolohii, 2, 6–11 [in Russian].

Dolomatov, S. I., Zukov, V., Atmazhov, I. D., Muszkieta, R., & Skaliy, A. (2012) The use of hormones indicators in human saliva in diagnosing parodontitis in pregnant women. Indian J. Hum. Genet, 18(3), 305–309. doi: 10.4103/0971-6866.107982.

Gümüş, P., Öztürk, V. O., Bozkurt, E., & Emingi, G. (2016) Evaluation of the gingival inflammation in pregnancy and postpartum via 25-hydroxy-vitamin D3, prostaglandin E2 and TNF-α levels in saliva. Arch. Oral. Biol, 63, 1–6. doi: 10.1016/j.archoralbio.2015.11.018.

Dursun, E., Akalın, F. A., Güncü, G. N., Çınar, N., Aksoy, D. Y., Tözüm, T. F., et al. (2011) Periodontal disease in polycystic ovary syndrome. Fertil. Steril., 95(1), 320–323. doi: 10.1016/j.fertnstert.2010.07.1052.

Danylevskyi, M. F., Boryisenko, A. V., Politun, A. M., Sidelnikova, L. F., & Nesyti, O. F. Terapevtychna stomatolohiia [Therapeutic stomatology]. (Vol. 2). Kyiv: Zdorovia. [in Ukrainian]

Kosenko, K. N., Romanova, Yu. G., Dvulit, I. P. et al. (2010) Lechebno-profilakticheskie zubnye e'liksiry [Treatment and preventive dental mouth wash. A manual]. Odessa: KP OGT. [in Russian]

Levickij, A. P., Den'ga, O. V., Makarenko, O. A., et al. (2010) Biokhimicheskie markery vospaleniya tkanej rotovoj polosti [Biochemical markers of inflammation of the tissues of the oral cavity]. Odessa: KP OGT. [in Russian]

Levickij, A. P., Makarenko, O. A., Selivanskaya, I. A., et al. (2007) Fermentativnyj metod opredeleniya disbioza polosti rta dlya skrininga pro- i prebiotikov [Enzymatic method for determining oral dysbiosis for screening pro and prebiotics]. Kyiv: GFC. [in Russian]

Kirkwood, B. R., & Sterne, A. C. (2003) Essential medical statistic. Blackwell Publishing.

How to Cite

1.
Romanova YG, Dizik SV. The influence of combined antioxidants usage on periodontal pathology in women with polycystic ovarian syndrome. Zaporozhye Medical Journal [Internet]. 2018Mar.7 [cited 2024Oct.10];(2). Available from: http://zmj.zsmu.edu.ua/article/view/125272

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Section

Original research