Analysis of changes in biochemical parameters of oral liquid under the influence of lecithin-calcium complex in young patients with multiple caries
DOI:
https://doi.org/10.14739/2310-1210.2018.3.130474Keywords:
caries, lecithin, calcium citrate, dysbiosis, antioxidant-prooxidant indexAbstract
Given the high prevalence of dental caries, it is important to find new means and methods of prevention. At present preparations of natural origin, such as lecithin and calcium citrate, are widely used.
The aim was to study the lecithin-calcium complex effect on the oral fluid biochemical parameters of individuals with multiple dental caries.
Materials and methods. 85 KhNMU Dental Faculty students-volunteers were examined. Groups of participants were formed depending on the dental caries intensity level index value for the oral fluid biochemical parameters determination (degree of oral dysbiosis, antioxidant-prooxidant index) in patients before and after the start of the lecithin-calcium complex treatment course.
Results. In persons with multiple dental caries the degree of dysbiosis is 3 times higher than normal, the concentration of calcium decreases by 1.5 times and the antioxidant-prooxidant index reduces by 2 times. After lecithin-calcium complex treatment course the dysbiosis degree decreases almost by 8 times, the concentration of calcium and API return to normal. This indicates the ability of the lecithin-calcium complex to regulate the oral cavity microbiocenosis and restore antioxidant-prooxidant indices.
Conclusions. In patients with multiple dental caries the phenomena of the oral cavity dysbiosis, a decrease in the protective antioxidant system level and a decrease in the oral fluid calcium concentration are observed. The lecithin-calcium complex intake during the month completely eliminated the phenomenon of dysbiosis in the oral cavity, increased the antioxidant-prooxidant system level and the oral fluid calcium concentration to normal.
References
Marchenko, N. S. (2013). Sostoyanie stomatologicheskogo zdorov'ya studentov medikov [The state of dental health of medical students]. Endofile, 3–4, 32. [in Russian].
Tarasova, N. V., Bril, E. A., Fedorova, T. V., Fedorov, V. A., & Galonskij, V. G. (2012) Rol' gigienicheskogo vospitaniya v sisteme pervichnoj profilaktiki stomatologicheskikh zabolevanij [The role of hygienic education in the system of primary prevention of dental diseases]. Sibirskoe medicinskoe obozrenie, 4(76), 6–11. [in Russian].
Volkova, O. S., & Volkov, S. N. (2009). Biokhimicheskie izmeneniya v syvorotke krovi krys, soderzhashchikhsya na kariesogennoj diete s dobavleniem fosfatidilkholina (lecitina), rastitel'nogo masla i preparata kal'ciya [The biochemical changes in blood serum of rats, kept to cariesgenic diet with phosphatidylcholine (lecithin), vegetable oil and calcium preparation]. Vіsnyk stomatolohii, 1(66), 6–10. [in Russian].
Denisov, A. B. (2009). Slyuna i slyunnye zhelezy [Saliva and salivary glands]. Moscow: Izdatelstvo RAMN. [in Russian].
Novitskaya, I. K., & Tereshina, T. P. (2013). Rol' slyuny v obespechenii processov mineralizacii zubov (obzor) [Saliva role in ensuring processes of the mineralization of teeth (review)]. Innovatsii v stomatolohii, 2, 37–41. [in Russian].
Noskov, V. B. (2008). Slyuna v klinicheskoj laboratornoj diagnostike (obzor literatury) [Saliva in clinical laboratory diagnosis (a review of literature)]. Klinicheskaya laboratornaya diagnostika, 6, 14–16. [in Russian].
Levitskij, A. P., Demjanenko, S. A., Pustovojt, P. I., Tokar, E. A., Anshukova, O. I., Goncharuk, S. V., & Skiba, V. Ja. (2011). Biokhimicheskiye markery vospaleniya i disbioza v slyune bol'nykh holecistitom [The biochemical markers of inflammation and disbiosis in saliva of patients with cholecystitis]. Vіsnyk stomatologiyi, 1(74), 21–23. [in Russian].
Stal'naya, I. D., & Garishvili, T. G. (1977). Metod opredeleniya malonovogo dial'degida s pomoshch'yu tiobarbiturovoj kisloty [Method of determination of malondialdehyde with tiobarbituric acid]. Sovremennyye metody v biokhimii. (P. 66–68). Moscow: Medicina. [in Russian].
Levickij, A. P., Konovec, V. M., L'vov, I. F., Barabash, R. D., & Volodkina, V. V. (1973). Kallikreiny i nespecificheskie proteazy v slyune bol'nykh yazvennoj bolezn'yu zheludka i dvenadcatiperstnoj kishki [Kalicreatins and nonspecific proteases in the saliva of patients with ulcerous stomach and duodenal ulcers]. Voprosy medicinskoj khimii, 19(6), 633–638. [in Russian].
Girin, S. V. (1999). Modifikaciya metoda opredeleniya aktivnosti katalazy v biologicheskikh substratakh [Modification of the method for determining the activity of catalase in biological substrates]. Laboratornaya diagnostika, 4, 45–46. [in Russian].
Kaskova, L. F., & Marchenko, K. V. (2012). Zmina rivnia aktyvnosti lizotsymu ta ureazy rotovoi ridyny v ditei u protsesi profilaktychnykh zakhodiv [Changing the level of activity of lysozyme and urease of oral liquid in children in the process of preventive measures]. Ukrainskyi stomatolohichnyi almanakh, 2, 97–99. [in Ukrainian].
Gavrikova, L. M., & Segen', I. T. (1996). Ureaznaya aktivnost' rotovoj zhidkosti u bol'nykh s ostroj odontogennoj infekciej chelyustno-licevoj oblasti [Urease activity of the oral liquid in patients with acute odontogenic infection of the maxillofacial area]. Stomatologiya, 75, 49–50. [in Russian].
Kaskova, L. F. Pavlenkova, O. S. (2015). Pokazateli lizocima i ureazy rotovoj zhidkosti detej,. chasto boleyushchikh ORVI [Indicators of lysozyme and ureas of oral fluid in children who are often ill with ARVI]. Molodoj uchenyj, 16 (96), 71–73. [in Russian].
Levickij, A. P., Den'ga, O. V., Makarenko, O. A., et al. (2010). Biokhimicheskie markery vospaleniya tkanej rotovoj polosti [Biochemical markers of inflammation of the tissues of the oral cavity]. Odessa. [in Russian].
Levickij, A. P., Makarenko, O. A., Selivanskaya, I. A., Rossakhanova, L. N., Den'ga, O. V., Pochtar, V. N., et al. (2007). Fermentativnyj metod opredeleniya disbioza polosti rta dlya skrininga pro- i prebiotikov [Enzymatic method for determining oral dysbiosis for screening pro- and prebiotics]. Kyiv: GFC. [in Russian].
Downloads
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
