Collagen-associated syntropy in children with functional disorders of the digestive system

Authors

  • T. V. Stoieva Odesa National Medical University, Ukraine,
  • O. V. Dzhagiashvili Odesa National Medical University, Ukraine,
  • S. V. Prokhorova Odesa National Medical University, Ukraine,
  • V. A. Gudz Regional Children's Clinical Hospital, Odesa, Ukraine.,
  • O. Yu. Yemelyanova City Children's Hospital No. 1 named after B. Y. Reznik, Odesa Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.3.130520

Keywords:

children, gastrointestinal diseases, connective tissue disease, type III collagen (COL3A1), synthropic pathology

Abstract

Objective. The aim of this study was to determine the features of collagen-associated syntropic pathology in children with functional gastrointestinal disorders.

Materials and methods. 63 children with functional gastrointestinal disorders aged 2.5 to 16 years were examined. Two clinical groups of patients depending on the leading clinical manifestations were identified: children with irritable bowel syndrome – 39 patients (61.9 %) and children with functional disorders of the biliary tract – 24 (38.1 %) of patients. All children, except for the general clinical examination, were evaluated for individual phenotypic signs of connective tissue dysplasia using diagnostic criteria for the severity of connective tissue dysplasia by L. N. Abbakumova, and collagen type III alpha 1 polymorphism (rs1800255 2092G>A) by PCR-RFLP (restriction fragment length polymorphism) method was determined.

Results. Digestive system syntropic pathology was defined in 84.13 % (95 % CI 74.93 – 93.33) of the examined patients. A statistically significant association was found between the frequency of gallbladder anomalies (χ2 = 8.75; P = 0.003), pancreas exocrine function violation (χ2 = 8.97, P = 0.003), metabolic disturbances presence in the form of secondary acetonemic syndrome (χ2 = 8.5; P = 0.001) and functional disorders of the biliary tract. The severity of connective tissue dysplasia in preschool children was characterized by mild and moderate manifestations (OR = 4.27 (95 % CI 1.32 – 13.82; P = 0.025)), there were severe manifestations of dysplasia in the older children group (OR = 0.23 (95 % CI 0.07 – 0.76, P = 0.025)). By the results of molecular-genetic test the most of children – 47.62 % (95 % CI 35.04 – 60.2) were genotyped for heterozygous rs1800255, COL3A1 G/A polymorphism, with significant prevalence of patients with the biliary tract functional disorders group (P = 0.008), which associated with wide range of accompanying pathology (P = 0.002) and severe dysplastic signs (P = 0.034).

Conclusions. The wide prevalence of the syntropic pathology in children with functional gastrointestinal disorders has been determined. Genetic polymorphism with predominance of the G/A genotype has been revealed. The statistically significant correlation of the G/A genotype with severe phenotypic signs of connective tissue dysplasia has been shown. The association of genetic polymorphism with age and functional disorders of the biliary tract has been established.

 

References

Babceva, A. F., Shanova, O. V., Bojchenko, T. E., Arutyunyan, K. A., & Romancova, E. B. (2010). Displaziya soedinitel'noj tkani u detej i podrostkov [Connective tissue dysplasia in children and adolescents]. Blagoveschensk. [in Russian].

Belousov, Yu. V. (2012). Komorbidnost' pri zabolevaniyakh pishhevaritel'noj sistemy u detej [Comorbidity in diseases of the digestive system in children]. Zdorov'e rebenka, 1, 134–138. [in Russian].

Ivanova, I. I., Gnusaev, S. F., Apenchenko, J. S., Kapustina, L. V., Gerasimov, N. A., & Soldatova, I. A. (2012). Osobennosti proyavlenij zabolevanij pishhevaritel'nogo trakta u detej s displaziej soedinitel'noj tkani [The characteristic manifestations of digestive tract disorders in children with connective tissue dysplasia]. Voprosy sovremennoj pediatrii, 5, 50–55. [in Russian].

Ursova, N. I. (2014). Funkcional'nye narusheniya biliarnogo trakta u detej kak mul'tidistsiplinarnaya problema [Functional disorders of the biliary tract in children as a multidisciplinary problem]. Аl'manakh klinicheskoj mediciny, 33, 47–56. [in Russian].

Bogomolova, I. K., Peregoedova, V. N., & Solovieva, Yu.G. (2015). Khronicheskie zapory u detej: prichiny, mekhanizmy razvitiya, klinika [Chronic constipation in children: causes, pathogenesis, clinical]. Zabajkal'skij medicinskij vestnik, 3, 121–129. [in Russian].

Lukianenko, N. S., Petritsa, N. A., & Kens, K. A. (2015). Mistse nedyferentsiiovanoi dysplazii spoluchnoi tkanyny v patolohii dytiachoho viku [Place of undifferentiated connective tissue dysplasia in childhood pathology]. Zdorov`e rebenka, 2, 80–85. [in Ukranian].

Oshlyanska, O. A., & Vovk, V. M. (2017). Osoblyvosti zakhvoriuvanosti na hostru respiratornu patolohiiu u ditei z nedyferentsiiovanoiu dysplaziieiu spoluchnoi tkanyny [Incidence peculiarities of acute respiratory disease among children with undifferentiated connective tissue dysplasia]. Perinatologiya i pediatriya, 1, 115–120. [in Ukranian].

Аpenchenko, Yu. S., Basalaeva, N. V., Kapustina, L. V., & Ivanova, I. I. (2014). Klinicheskie i biokhimicheskie priznaki displazii soedinitel'noj tkani u detej s gastroe'zofageal'noj reflyuksnoj bolezn'yu [Сonnective tissue dysplasia in children with gastroesophageal reflux disease: clinical and biochemical features]. Vestnik Ivanovskoj medicinskoj akademii, 3, 17–19. [in Russian].

Skvortsovа, E. M., Skvortsov, V. V., Mukhtаrov, T. А., Potаpovа, M. V., Skvortsov, K. Y., & Fedorovа, O. F. (2015). Sovremennye problemy diagnostiki i lecheniya funkcional'nykh rasstrojstv zheludochno-kishechnogo trakta [Current problems in the diagnosis and treatment of functional disorders of the gastrointestinal tract]. Medicinskij sovet, 13, 112–117. [in Russian].

Konoplytsky, V. S., Pogoriliy, V. V., Lukiyanets, O. A., & Nesterenko, I. G. Fenotypichnyi prostorovyi kontynuum dysplazii spoluchnoi tkanyny u ditei z dolikhosihmoiu [Phenotypical spatial continuum of connecting tissue dysplasia in children with dolichosigmoid]. Aktualni problemy suchasnoi medytsyny: visnyk ukrainskoi medychnoi stomatolohichnoi akademii, 16, 1(53), 118–121. [in Ukranian].

Till, H., ‎Thomson, M.,‎ & Foker, J. E. (2017). Esophageal and Gastric Disorders in Infancy and Childhood. Berlin Heidelberg, MA: Springer-Verlag.

Saravani, S., Yari, D., Saravani, R., & Azadi Ahmadabadi, C. (2017). Association of COL4A3 (rs55703767), MMP-9 (rs17576) and TIMP-1(rs6609533) gene polymorphisms with susceptibility to type 2 diabetes. Biomedical Reports, 6(3), 329–334. doi: 10.3892/br.2017.856.

Gan, Q., Liu, Q., Hu, X., & You, C. (2017). Collagen Type I Alpha 2 (COL1A2) Polymorphism Contributes to Intracranial Aneurysm Susceptibility: A Meta-Analysis. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 23, 3240–3246. doi: 10.12659/MSM.902327.

Ward, R. M., Velez Edwards, D. R., Edwards, T., Giri, A., Jerome, R. N., & Wu, J. M. (2014). Genetic Epidemiology of Pelvic Organ Prolapse: A Systematic Review. American Journal of Obstetrics and Gynecology, 211(4), 326–335. doi: 10.1016/j.ajog.2014.04.006.

How to Cite

1.
Stoieva TV, Dzhagiashvili OV, Prokhorova SV, Gudz VA, Yemelyanova OY. Collagen-associated syntropy in children with functional disorders of the digestive system. Zaporozhye Medical Journal [Internet]. 2018May30 [cited 2024Nov.23];(3). Available from: http://zmj.zsmu.edu.ua/article/view/130520

Issue

Section

Original research