Interrelation between neutrophil-lymphocyte ratio and chronic lower limb ischemia

Authors

  • O. M. Voloshyn Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.3.132117

Keywords:

atherosclerosis, ischemia, arterial occlusive diseases, lower limb

Abstract

Purpose. The aim is to study the specifics of neutrophil - lymphocyte ratio (NLR) in patients with chronic lower extremity ischemia.

Material and methods. In the course of the prospective study, the analysis of the NLR parameters in 282 patients with peripheral arterial occlusions was performed. All patients were divided into 4 groups, according to the classification of peripheral arterial disease - TASC II. Evaluation of the NLR parameters was performed on admission before surgical or conservative treatment administration.

Results. The average NLR number by groups was as follows: TASC A – 2.76 ± 0.72; TASC B – 4.00 ± 1.2; TASC C – 4.5 ± 2.38 and TASC D – 5.15 ± 2.09. NLR level significantly increased with a greater degree of TASC II. The indices of NLR were significantly higher in patients with a more “aggressive” and multilevel type of lesions, namely TASC II C and D. In patients with lesions type D the level of NLR was 46.4 % more than in patients with TASC II type A lesion.

Conclusions. The value of neutrophil-lymphocyte ratio was 29.8 % (P < 0.05) higher in patients with C and D atherosclerotic lesion types according to TASC II classification than in patients with lesions of type A and B. Neutrophil-lymphocyte ratio greater than 3.05 could be interpreted as a marker of more diffuse lower limb atherosclerotic lesion given the sensitivity and specificity levels (70.7 %, 75.8 %; P <  0.001).

 

 

 

 

 

 

References

Norgren, L., Hiatt, W. R., Dormandy, J. A., Nehler, M. R., Harris, K. A., & Fowkes, F. G. (2007) Inter-Society Consensus for the Management of Peripheral Arterial Disease (TASC II). J Vasc Surg,. 45, S:S5–67. doi: 10.1016/j.jvs.2006.12.037.

Schanzer, А., Mega, J., Meadowset, J., Samson, R. H., Bandyk, D. F., & Conte, M. S. (2008) Risk stratification in critical limb ischemia: derivation and validation of a model to predict amputation-free survival using multicenter surgical outomes data. J Vasc Surg., 48, 1464e71. doi: 10.1016/j.jvs.2008.07.062.

Libby, P., Ridker, P. M., & Hansson, G. K. (2009) Inflammation in atherosclerosis:from pathophysiology to practice. J Am Coll Cardiol., 54, 2129–2138. doi: 10.1016/j.jacc.2009.09.009.

Tamhane, U. U., Aneja, S., Montgomery, D., Rogers, E. K., Eagle, K. A., & Gurm, H. S. (2008) Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol., 102(6), 653–7. doi: 10.1016/j.amjcard.2008.05.006.

Aykan, A. Ç., Hatem, E., Kalaycıoğlu, E., Karabay, C. Y., Zehir, R., Gökdeniz, T., et al. (2015) Neutrophil-to-lymphocyte ratio may be a marker of peripheral artery disease complexity. Anatol J Cardiol., 16(7), 497–503. doi: 10.5152/AnatolJCardiol.2015.6240.

Spark, J. I., Sarveswaran, J., Blest, N., Charalabidis, P., & Asthana, S. (2010) An elevated neutrophilelymphocyte ratio independently predicts mortality in chronic critical limb ischemia. J Vasc Surg., 52(3), 632–6. doi: 10.1016/j.jvs.2010.03.067.

Bhutta, H., Agha, R., Wong, J., Tang, T. Y., Wilson, Y. G., & Walsh, S. R. (2011) Neutrophilelymphocite ratio predicts medium term survival following elective major vascular surgery: a cross sectional study. Vasc Endovasc Surg., 45(3), 227–31. doi: 10.1177/1538574410396590.

How to Cite

1.
Voloshyn OM. Interrelation between neutrophil-lymphocyte ratio and chronic lower limb ischemia. Zaporozhye Medical Journal [Internet]. 2018May30 [cited 2024Nov.23];(3). Available from: http://zmj.zsmu.edu.ua/article/view/132117

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Section

Original research