Effect of glucosamine and acetylsalicylic acid preparations on the skin histostructure after acute cold trauma
DOI:
https://doi.org/10.14739/2310-1210.2018.4.135381Keywords:
cold injury, physiological stress, glucosamine, aspirinAbstract
Aim. The study of the glucosamine and acetylsalicylic acid action on the morphological changes of the foot pads of hindlegs and the tip of rats’ tail after acute cold trauma (CT).
Materials and methods. Rats were modeled CT in the Nord Inter-300 freezer at –18 °C for 2 hours. The study drugs – acetylsalicylic acid (25 mg/kg), "Glucosamine-C BHFZ" (82.5 mg/kg) and glucosamine hydrochloride (50 mg/kg) were administered prophylactically 30 min before acute CT.
Results. Glucosamine hydrochloride and "Glucosamine-C BHFZ"It has been determined to have a marked positive effect on the rat skin histological structure in comparison with the reference drug (acetylsalicylic acid).
Conclusions. The most marked frigoprotective effect had glucosamine hydrochloride and "Glucosamine-C BHFZ" as with administration of which there were no inflammatory reactions in the dermis and microcirculation disturbances were not observed. In the group of animals treated with glucosamine hydrochloride the histological structure corresponded to the intact control group. Acetylsalicylic acid did not restore the animals’ skin histological structure as pronounced hyperkeratosis, keratinocytes dystrophy and inflammatory reaction in the dermis and in the subcutaneous adipose tissue were observed.
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