Study of structural-mechanical properties of the ointment base

Abstract

The ENTRY. For the local treatment of surgical wounds basis of a medicine plays an important role in ensuring its therapeutic effect. Ointment framework depends on adequate frequency of applications, pharmacokinetics, therapeutic effect and absence/presence of side effects. Unjustifiable selected the basis of a medicinal product may cause not only the increase or reduction of the actions of the active substance, but also a total absence of it.

The AIM of the WORK was to develop composition and technology of production of combined emulsion of a medicine for the treatment of surgical wounds that meet the modern medical-biological requirements.

MATERIALS AND METHODS OF RESEARCH. Rheological studies carried out with the help of rotary viscometer with coaxial cylinders «Rheotest-2» (Germany). For the study took the hinge of a pilot sample.

RESULTS AND THEIR DISCUSSION. Based on the biomedical requirements to create a combination of soft drugs for the treatment of wound healing we conducted research to establish ointments emulsion based on first order. As emulsifier of the first kind were used twin-80 and stearic acid, and emulsifier of the second kind - monostearat glycerin. For the comparative analysis was taken a comprehensive emulsifier No.1. It is established, that the use of a complex of emulsifiers stearic acid, emulsifier No.1 the highest structural-mechanical parameters have emulsion with the ratio of surface-active substances of 2.5 % and 5.5%, respectively. With the increase in the stearic acid emulsion was increase in the rheological parameters of the model for all shear rates. Also the composition of model samples at different ratios of emulsifier No.1 and the twin-80. Determined that the maximum value rheological parameters observed in the ratio of: emulsifier No.1-twin-80 (1:7). With the increase in the emulsions quantity of emulsifier No.1 rheological parameters increases sharply for all speeds of the shift. This non-linear dependence, indicating a type of non-Newtonian flow of ointment. With increasing shear rate curves offset voltage gradually grow, and then pass in a direct, which testifies to the gradual full destruction of the structure. It should be noted that the largest index of viscosity of structural model has the composition, which contains a mixture of stearic acid, emulsifier No.1 in the ratio of 2.5 % and 5.5 % respectively, which is used for further researches.

The composition of the ointment base for the treatment of surgical wounds and in the phase of the wound process has the following form:

Oil petroleum jelly 20,0

Stearic acid 2,5

Emulsifier No.1 5,5

Glycerine 5,0

Peo-400 10,0

Purified water to 100.0

CONCLUSION. By conducting structural-mechanical studies founded composition emulsion base that can be used in the development of the composition of the new ointment with wound-healing and anti-bacterial properties for applications in the first phase of the wound process.

Key words: wound, emulsifier, emulsive basis, oily phase.