Tuberculosis course in a patient with Fahr’s disease (a clinical case report)
DOI:
https://doi.org/10.14739/2310-1210.2018.5.141727Keywords:
tuberculosis, Fahr’s diseaseAbstract
In the present context, pulmonary tuberculosis, especially its resistant forms, is an urgent problem of society, not only inUkraine, but also throughout the world. As is known, comorbidities make difficult not only tuberculosis diagnostics, but also its treatment. Tuberculosis can either develop on the background of any diseases or cause their development and exacerbations. On account of this there are rare diseases of various organs and systems which are characterized by a long absence of clinical symptoms.
Work objective is to draw the attention of doctors to the combined course of tuberculosis and rare neurological diseases such as Fahr’s disease.
Materials and methods. The article deals with the clinical case based on own observations of the pulmonary multidrug-resistant tuberculosis (MRTB) development in a patient with Fahr’s disease diagnosed in the process of tuberculosis treatment. The patient received inpatient treatment in the Department of Pulmonary Tuberculosis No. 3 of the clinical base of the Phthisiology and Pulmonology Department of the ZSMU in the Communal Institution “Zaporizhzhia Regional Tuberculosis Clinical Dispensary”.
Results of own observations. It has been defined that the patient had experienced slow asymptomatic course of Fahr’s disease prior to the onset of pulmonary MRTB. Probably, the toxic effect of antimycobacterial drugs provoked clinical manifestations of Fahr’s disease in the form of neurological symptoms. If Fahr’s disease had been timely diagnosed, antimicrobial therapy would have been prescribed with appropriate initial treatment correction through the exclusion of antimycobacterial drugs with neurotoxic effects from the chemotherapy regimen. Such an approach might not have exacerbated the underlying disease.
Conclusions. In a patient with Fahr’s disease the pulmonary MRTB can be treated provided constant monitoring by a neuropathologist with the prescription of adequate symptomatic and pathogenetic therapy that could prevent severe neurological disorders development.
References
Matveeva, T. V., & Ovsyannikova, S. O. (2016). Pervichnaya (boleznʹ Fara) i vtorichnaya kal'cifikaciya bazal'nykh gangliev (klinicheskoe nablyudenie) [Primary (Fahr disease) and secondary calcification of the basal ganglia (clinical observation)]. Nevrologicheskij vestnik. Zhurnal im. V.M. Behtereva, 48(2), 57–62. [in Russian].
Yevtushenko, S. K. & Yevtushenko, I. A. (2016). Patogenez i klinicheskie proyavleniya yuvenil'noj i senil'noj form bolezni Fara (nauchnyj obzor) [Pathogenesis and clinical manifestations of juvenile and senile Fahr disease (scientific review)]. Mizhnarodni nevrolohichnyi zhurnal, 1(79), 159–162. [in Russian].
Kalinin, A. P., Kotov, S. V., & Rudakova, I. G. (2009). Nevrologicheskie rasstrojstva pri e'ndokrinnykh zabolevaniyakh [Neurologicaldisorders in endocrinediseases]. Moscow. [in Russian].
Tishchenko, V. N., & Tishchenko, G. V. (2013) Bolezn' Fara pri patologoanatomicheskom issledovanii [Fahr disease in postmortem examination (case report)]. Problemy zdorov'ya i e'kologii, 2(36), 146–150. [in Russian].
Zagorovskaya, T. B., Illarioshkin, S. N., Bryukhov, V. V., & Timerbaeva, S. L. (2014). Bolezn' Parkinsona i idiopaticheskaya striatopallidodentatnaya kal'cifikaciya [Parkinson's disease and idiopathic striatopallidodentatecalcification]. Nervnye bolezni, 1, 32–36. [in Russian].
Chernysheva, E. A., Zinovyeva, O. E., Solokha, O. A., Obukhova, A. V., Zakharov, V. V., Ivashkin, V. T., & Yakhno, N. N. (2015). Intratserebral'nyj kal'cinoz u pacienta s khronicheskim vospalitel'nym zabolevaniem kishechnika [Intracerebral calcification in a patient with chronic inflammatory bowel disease]. Nevrologicheskij zhurnal, 20(3), 54–57. [in Russian].
Ivanchenko, E. N., Shedenko, M. I., Spizharsky, E. V., Dolganovskaya, N. N., & Kondrateva, A. A. (2016). Klinicheskij sluchaj bolezni Fara [Clinical case of Fahr disease]. Omskij psihiatricheskij zhurnal, 3(9), 11–15. [in Russian].
Ministerstvo okhorony zdorovia (2014). Nakaz MOZ Ukrainy «Ukraina. MOZ. Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) ta tretynnoi (vysokospetsializovanoi) medychnoi dopomohy doroslym. Tuberkulioz» vid 31.12.2014 roku №620 [Order of the Ministry of Health of Ukraine «Unified clinical protocols of primary, secondary (specialized) and tertiary (highly specialized) medical care for adults «Tuberculosis» from December 31, 2014, №620]. [in Ukrainian].
Pistacchi, M., Gioulis, M., Sanson, F., & Marsala, S. M. (2016). Fahr'ssyndrome and clinical correlation: a caseseries andl iterature review. Folianeuropathologica, 54(3), 282–294.
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