Lipid spectrum and sex hormones content in patients with chronic hepatitis С

Authors

  • V. M. Kozko Kharkiv National Medical University, Ukraine,
  • K. V. Yurko Kharkiv National Medical University, Ukraine,
  • N. Ye. Khrystenko Kharkiv National Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2018.6.146692

Keywords:

chronic hepatitis C, lipid metabolism, gonadal steroid hormones

Abstract

Aim. To study the lipid metabolism indexes and sex hormones level in the blood serum of patients with chronic hepatitis C.

Materials and methods. The content of hormones and lipid metabolism were determined in 33 patients with chronic hepatitis C. Among them 27 (81.8 %) were men and 6 (18.2 %) were women with an average of 39.27 ± 1.53 years old. The study of plasma lipid profile (total cholesterol, triglyceride, high-density lipoproteins, low-density and very low-density lipoproteins) was carried out using enzymic photometric methods. The study of blood hormone levels was carried out by the dual-wavelength fluorescent detection.

Results. Reliable lipid metabolism violations were revealed, namely significant increase in triglyceride, low-density lipoproteins, very low-density lipoproteins and decrease in high-density lipoproteins in the blood serum of patients with chronic hepatitis C. Total cholesterol level in patients with chronic hepatitis C had no significant difference with that of the control group patients (P > 0.05). There was significant 2,7 times (P < 0.001) increase in serum progesterone in men and its significant 1.86 times (P < 0.05) decrease in women with chronic hepatitis C. There was no significant difference in serum testosterone level parameters between men with chronic hepatitis C and the control group (P > 0.05), while there was significant 2.98 times decrease in serum testosterone in women with chronic hepatitis C compared to the control group (P < 0.001). In patients with chronic hepatitis C a decreasing tendency in the serum estradiol was determined in men (P >0.05) and its significant reduction in the serum of women (P < 0.01) compared to the control group.

Conclusions. Violations of lipid metabolism have been determined in patients with chronic hepatitis C in terms of significant increase in triglyceride (P < 0.001), low-density lipoproteins (P < 0.001), very low-density lipoproteins (P < 0.001) and decrease in high-density lipoproteins (P < 0.001) in the blood serum. Disorders of sexual hormones levels have been revealed in the examined patients, namely decrease in serum progesterone (P < 0.05), testosterone (P < 0.001) and estradiol (P < 0.01) in women and increase in serum progesterone (P < 0.001) in men.

 

References

Ustinov, O. V. (2014) Alhorytm dii likaria pry nadanni medychnoi dopomohy patsientam iz dyspersiieiu [The algorithm of the physician actions in providing medical care to patients with dyspepsia]. Ukrainskyi medychnyi chasopys, 5, 179–182. [in Ukrainian].

Golubovskaya, O. A., & Kulrsh, O. V. (2014) Perebih khronichnoho hepatytu C na tli metabolichnykh chynnykiv ryzyku yak skladovykh metabolichnoho syndromy ta suchasni pidkhody do yoho korektsii [The course of chronic hepatitis С against the background metabolic risk factors as the components of metabolic syndrome and modern approaches to its correction]. Suchasna hastroenterolohіia, 5(79), 93–98. [in Ukrainian].

Moroz, L. V., Kirichenko, D. F., Semaniv, M. V., & Grishilo, M. S. (2012) Osoblyvosti perebihu tsitokin-indukovanoi anemii pry khronichnomu hepatyti C [Features of cytokine-induced anemia of patients with chronic hepatitis C]. Visnyk Vinnytskoho natsionalnoho medychnoho universitetu, 1(1), 74–77. [in Ukrainian].

Golubovska, O. A., Andreichyn, M. A., & Shkurba, A. V. (2012) Infektsiini khvoroby [Infectious disease]. Kyiv: Medytsyna. [in Ukrainian].

Yershova, I. B., Mochalova, A. A., Karpenko, I. N., & Netrunenko, L. V. (2013) Filosovskie i prakticheskie problemy khronicheskikh virusnykh gepatitov [Philosophy and practical problems of chronic viruses hepatitis]. Aktual'naya infektolohiya, 1(1), 21–24. [in Russian].

Felmlee, D. J., Hafirassou, M. L., Lefevre, M., Baumert, T. F., & Schuster, C. (2013) Hepatitis C Virus, Cholesterol and Lipoproteins – Impact for the Viral Life Cycle and Pathogenesis of Liver Disease. Viruses, 5(5), 1292–1324. doi: 10.3390/v5051292.

Tkachenko, L. I., Maleev, D. M., & Sarieva, D. M. (2015) Narushenie lipidnogo obmena u bol'nykh khronicheskim virusnym gepatitom C [Lipid metabolism disorders in patients with chronic hepatitis C]. Arkhiv vnutrennej mediciny, 6(26), 50–56. [in Russian].

Kozko, V., Antsyferova, N., Solоmennyk, А., Yurko, К., Bondar, А., Vinokurovа, О., & Penkov, D. (2015) Diahnostyka fibrozu pechinky u khvorykh na khronichnyi hepatyt C: suchasnyi stan, problemy ta perspektyvy [Diagnostics of liver fibrosis in patients with chronic hepatitis C: current state of problems and prospects]. Hepatolohiia, 1, 27–33. [in Ukrainian].

Yuhui Wang, Jose Viscarra, Sun-Joong Kim & Hei Sook Sul. (2015) Transcriptional regulation of hepatic lipogenesis. Nature Reviews Molecular Cell Biology, 16, 678–689. doi: [10.1038/nrm4074].

Iurko, K. V. (2015) Otsinka porushen vuhlevodnoho obminu u VIL-infikovanykh osib, khvorykh na HGC i ko-infektsiiu VIL/HGC [Assessment of carbohydrate metabolism disorders in HIV-infected persons, patients with chronic hepatitis c and co-infection HIV/HCV]. Annaly Mechnykovskoho instytutu, 2, 95–99. [in Ukrainian].

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How to Cite

1.
Kozko VM, Yurko KV, Khrystenko NY. Lipid spectrum and sex hormones content in patients with chronic hepatitis С. Zaporozhye medical journal [Internet]. 2019Feb.1 [cited 2024Apr.25];(6). Available from: http://zmj.zsmu.edu.ua/article/view/146692

Issue

No. 6 (2018)

Section

Original research

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