Assessment of infusion therapy impact on the dynamics of endothelin-1 in patients with acute ischemic stroke

Authors

  • A. I. Semenenko National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • N. O. Semenenko National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • Н. I. Hrebtii Higher State Educational Establishment “Bukovinian State Medical University”, Chernivtsi, Ukraine,
  • S. L. Malуk National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • R. Ya. Bodnar Horbachevsky Ternopil State Medical University, Ukraine,
  • O. M. Hinhuliak Higher State Educational Establishment “Bukovinian State Medical University”, Chernivtsi, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2019.1.155796

Keywords:

stroke, solutions, endothelins, HES 130, HAES-LX-5 %, 0.9 % NaCl, mannitol

Abstract

The impact of infusion solutions on endothelial damage correction in acute ischemic stroke (AIS) remains an insufficiently studied.

Purpose. To investigate the dynamics of endothelin-1 as one of the main markers of vasoconstriction and endothelial dysfunction (ED) with the use of 0.9 % NaCl, HES 130, HAES-LX-5 % and mannitol in patients with AIS.

Materials and methods. The study included 32 patients with AIS. As the investigated solutions were used: colloid hyperosmolar HAES-LX-5 % (Gecoton), colloid isoosmolar hydroxyethylstarch 6% 130/04 (HES 130), hyperosmolar mannitol 15 %, isoosmolar 0.9 % NaCl. The control group consisted of patients who received only 0.9 % NaCl, comparison group patients received 0.9% NaCl + HES 130 or 0.9 % NaCl + HAES-LX-5 %, or 0.9 % NaCl + mannitol. The level of endothelin-1 (EN-1) served as a vasoconstriction marker of ED at a fixed time (days 1, 4 and 7).

Results. Infusion therapy with only 0.9 % NaCl negatively affected the level of EN-1, since its level was 3.17 times increased on the 7th day of observation in comparison with the 4th day (P < 0.05). In the course of seven-day treatment with mannitol, a sharp increase in EN-1 serum level on average 3.73 and 3.48 times higher on day 7 (P < 0.05) compared to days 1 and 4, respectively, was observed. Infusion therapy with HES 130 and HAES-LX-5 % solutions produced a moderate depressing effect. So, the HAES-LX-5 % and HES 130 groups demonstrated a trend towards a decrease in ЕN-1 level (P > 0.05) at the end of observation in comparison with mannitol and 0.9 % NaCl groups, which showed a paradoxical increase in its level at the 7th day of infusion.

Conclusions. The dynamics of EN-1 level as the main vasoconstrictor marker of ED were negative in the group of patients with 0.9 % NaCl and mannitol: its level was 3.17 and 3.48 times increased in the 0.9 % NaCl and mannitol groups (P < 0,05), respectively, on day 7 compared to day 4 of observation. Intensive therapy with HAES-LX-5 % and HES 130 had a better depressing effect on an increase in EN-1 level than other solutions.

 

References

Appleton, J.P, Sprigg, N., Bath, P.M. (2016). Blood pressure management in acute stroke. Stroke Vasc Neurol, 1(2), 72–82. doi: 10.1136/svn-2016-000020.

Eskes, G. A., Lanctôt, K. L., Herrmann, N., Lindsay, P., Bayley, M., Bouvier, L., et al. (2015). Canadian Stroke Best Practice Recommendations: Mood, Cognition and Fatigue Following Stroke Practices Guidelines, update 2015. Int. J. Stroke, 10(7), 1130–40. doi: 10.1111/ijs.12557.

Sharma, R., Gowda, H., Chavan, S., Advani, J., Kelkar, D., Kumar, G. S., Bhattacharjee, M., et al. (2015). Proteomic Signature of Endothelial Dysfunction Identified in the Serum of Acute Ischemic Stroke Patients by the iTRAQ-Based LC-MS Approach. J. Proteome Res, 14(6), 2466–2479. doi: 10.1021/pr501324n.

Martí-Fàbregas, J., Delgado-Mederos, R., Crespo, J., Peña, E., Marín, R., Jiménez-Xarrié, E., et al. (2015). Circulating endothelial progenitor cells and the risk of vascular events after ischemic stroke. PLoS One, 10(4), e0124895. doi: 10.1371/journal.pone.0124895.

Katerhenchuk, I. P. (2015). Klinichna otsinka, diahnostychne ta prohnostychne znachennia rezultativ laboratornykh doslidzhen. Chastyna 1: Kardiolohiia [Clinical evaluation, diagnostic and prognostic value of the results of laboratory research. Part 1: Cardiology]. Poltava: Medknyha. [in Ukrainian].

Domashenko, M. A., Orlov, S. V., Kostyreva, M. V., Tanashyan, М. M., lonova, V. G., & Suslina, Z. A. (2007). Sostoyanie funkcii e'ndoteliya pri ishemicheskikh narusheniyakh mozgovogo krovoobrascheniya [The endothelial functional status in patients with ischemic cerebrovascular disorders]. Nevrologicheskij zhurnal, 12(6), 10–14. [in Russian].

Ryabchenko, А. Yu., Dolgov, A. М., Denisov, Е. N., & Gumanova, N. G. (2014). Rol' oksida azota i e'ndotelina-1 v razvitii ishemicheskikh narushenij mozgovogo krovoobrascheniya [Role of nitric oxide and endothelin-1 in the development of ischemic disorders of cerebral circulation]. Nevrologicheskij vestnik. Zhurnal im. V.M. Behtereva, 46(1), 34–37. [in Russian].

Peng, Q., Huang, Y., Sun, W., & Xing, H. (2014). Associations among cerebral microbleeds, cerebral large-artery diseases and endothelial function. Chin. Med. J. (Engl). 127(18), 3204–3208.

Gumanova, N.G., Teplova, N.V., Ryabchenko, A.U., & Denisov, E.N. (2015). Serum nitrate and nitrite levels in patients with hypertension and ischemic stroke depend on diet: a multicenter study. Clin. Biochem, 48(1–2), 29–32. doi: 10.1016/j.clinbiochem.2014.10.010.

Shin, H. K., Oka, F., Kim, J. H., Atochin, D., Huang, P. L., & Ayata, C. (2014). Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J. Neurosci, 34(46), 15200–15207. doi: 10.1523/JNEUROSCI.1110-14.2014.

García-Pastor, A., Díaz-Otero, F., Funes-Molina, C., Benito-Conde, B., Grandes-Velasco, S., Sobrino-García, P., et al. (2015). Tissue plasminogen activator for acute ischemic stroke: calculation of dose based on estimated patient weight can increase the risk of cerebral bleeding. J. Thromb. Thrombolysis, 40(3), 347–52. doi: 10.1007/s11239-015-1232-4.

Brodoehl, S., Günther, A., Witte, O. W., & Klingner, C. M. (2015). How to manage thrombolysis interruptions in acute stroke? Clin. Neuropharmacol, 38(3), 85–88. doi: 10.1097/WNF.0000000000000081.

Tsivgoulis, G., Sharma, V. K., Mikulik, R., Krogias, C., Haršány, M., Bavarsad Shahripour, R., et al. (2014). Intravenous thrombolysis for acute ischemic stroke occurring duriццng hospitalization for transient ischemic attack. Int. J. Stroke, 9(4), 413–418. doi: 10.1111/ijs.12125.

Oddo, M., Poole, D., Helbok, R., Meyfroidt, G., Stocchetti, N., Bouzat, P., et al. (2018). Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations. Intensive Care Med, 44(4), 449–463. doi: 10.1007/s00134-018-5086-z.

Kurovska, V. O. (2012). Patohenetychni kryterii dyferentsiatsii roli NO-zalezhnykh mekhanizmiv v ishemichnykh i reperfuziinykh poshkodzhenniakh holovnoho mozku (Avtoref. dis…kand. med. nauk). [Pathogenetic Criteria for Differentiation of NO-Fallow Mechanisms in the Inhumous and Reperfusion Poses of the Brain] (Extended abstract of candidate’s thesis). Chernivtsi. [in Ukrainian].

Semenenko, A. I. (2013). Dynamika aktyvnosti neiron-spetsyfichnoi enolazy ta vmistu bilka S 100 u krovi schuriv za umov hostroho porushennia mozkovoho krovoobihu ta kursovoho vvedennia 0,9% rozchynu NaCl [The dynamics of neuron specific enolase activity and protein S 100 level in rat's blood under of acute disorder of the cerebral circulation and course intravenous injection of 0,9% solution NaCl]. Farmakolohiia ta likarska toksykolohiia, 6(36), 9–13. [in Ukrainian].

Semenenko, A. I. (2016). Aktyvnist neiron-spetsyfichnoi enolazy u patsientiv z hostrym ishemichnym insultom na foni korektsii infuziinymy rozchynamy [Act ivity of neuron-specific enolase in patient s with ac ute ischemic stroke on the background of correction of infusion solut ions]. Bil, znebolennia i intensyvna terapiia, 4(77), 52–58. [in Ukrainian]. doi: https://doi.org/10.25284/2519-2078.4(77).2016.94295.

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1.
Semenenko AI, Semenenko NO, Hrebtii НI, Malуk SL, Bodnar RY, Hinhuliak OM. Assessment of infusion therapy impact on the dynamics of endothelin-1 in patients with acute ischemic stroke. Zaporozhye Med J [Internet]. 2019Feb.8 [cited 2023Dec.5];(1). Available from: http://zmj.zsmu.edu.ua/article/view/155796

Issue

No. 1 (2019)

Section

Original research

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