Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress

Authors

  • N. O. Vlasenko

DOI:

https://doi.org/10.14739/2310-1210.2013.2.15587

Keywords:

mexidol, glutathione, stress, erythrocytes, bone marrow.

Abstract

Acute immobilization stress and its pharmacological correction with mexidol (2-ethyl-6-methyl-3-oxypyridine succinate) were modeled in albino male rats. The drug was administered to animals in  dose 100 mg/kg before stress exposure with following investigation of content of glutathione and its fractions (GSH, GSSG) in different terms of post-stress period. It is shown that mexidol enhances the level of reduced glutathione (GSH) in erythrocytes as well as in myeloid tissue in terms from 3 hrs to 5 days after the stress. It also regularly increases common glutathione concentration in erythrocytes in alarm stage of stress-syndrome (3-24 hrs). Such effect of mexidol, probably, is the consequence of its direct antioxidant action which lowers the load on physiological antioxidant system and promotes the maintenance of normal functional activity of erythron’s central and peripheral parts in stress.

How to Cite

1.
Vlasenko NO. Glutathione content in erythrocytes and bone marrow of animals in mexidol use under the conditions of acute stress. Zaporozhye Medical Journal [Internet]. 2013Jul.16 [cited 2024Nov.2];15(2). Available from: http://zmj.zsmu.edu.ua/article/view/15587

Issue

No. 2 (2013): Zaporozhye medical journal

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)