Comparative analysis of the influence of Corvitin and Lipoflavon on parameters of energy metabolism in the brain of rats with experimental severe craniocerebral trauma
DOI:
https://doi.org/10.14739/2310-1210.2013.2.15590Keywords:
craniocerebral trauma, corvitin, lipoflavon, energy metabolismAbstract
Hyperglycemia in rats develops in acute period of severe craniocerebral trauma: glucose consumption in rats’ brain increases, lactic acidosis develops, and the content of ATP decreases. Piracetam (200 mg/kg) does not eliminate hyperglycaemia but normalizes the level of intermediates of energy metabolism. Corvitin (100–150 mg/kg) eliminates hyperglycemia, normalizes the pyruvic and lactic acids, significantly increases the level of ATP. Lipoflavon (370 mg/kg) normalizes the blood level of glucose, increases the concentration of pyruvic and lactic acids, but it is worse than corvitin in its influence on ATP. Antihyperglycemic effect of lipoflavon is weaker at a dose of 555 mg/kg. The results illustrate craniocerebral effect of quercetin preparations.Downloads
Published
2013-07-17
How to Cite
1.
Zhilyaev SA, Shtrigol SY. Comparative analysis of the influence of Corvitin and Lipoflavon on parameters of energy metabolism in the brain of rats with experimental severe craniocerebral trauma. Zaporozhye Medical Journal [Internet]. 2013Jul.17 [cited 2024Nov.22];15(2). Available from: http://zmj.zsmu.edu.ua/article/view/15590
Issue
Section
Original research
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)