Comparative analysis of the influence of Corvitin and Lipoflavon on parameters of energy metabolism in the brain of rats with experimental severe craniocerebral trauma

Authors

  • S. A. Zhilyaev
  • S. Yu. Shtrigol

DOI:

https://doi.org/10.14739/2310-1210.2013.2.15590

Keywords:

craniocerebral trauma, corvitin, lipoflavon, energy metabolism

Abstract

Hyperglycemia in rats develops in acute period of severe craniocerebral trauma: glucose consumption in rats’ brain increases, lactic acidosis develops, and the content of ATP decreases. Piracetam (200 mg/kg) does not eliminate hyperglycaemia but normalizes the level of intermediates of energy metabolism. Corvitin (100–150 mg/kg) eliminates hyperglycemia, normalizes the pyruvic and lactic acids, significantly increases the level of ATP. Lipoflavon (370 mg/kg) normalizes the blood level of glucose, increases the concentration of pyruvic and lactic acids, but it is worse than corvitin in its influence on ATP. Antihyperglycemic effect of lipoflavon is weaker  at a dose of 555 mg/kg. The results illustrate craniocerebral effect of quercetin preparations.

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Published

2013-07-17

How to Cite

1.
Zhilyaev SA, Shtrigol SY. Comparative analysis of the influence of Corvitin and Lipoflavon on parameters of energy metabolism in the brain of rats with experimental severe craniocerebral trauma. Zaporozhye medical journal [Internet]. 2013Jul.17 [cited 2024Apr.16];15(2). Available from: http://zmj.zsmu.edu.ua/article/view/15590

Issue

No. 2 (2013): Zaporozhye medical journal

Section

Original research

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