Dynamics of endothelial dysfunction indices before and after operation in patients with varicose disease of the lower extremities

Authors

  • D. Yu. Riazanov SI “Zaporizhzhia Medical Academy of Postgraduate Education, MOH of Ukraine”,
  • O. V. Mamunchak SI “Zaporizhzhia Medical Academy of Postgraduate Education, MOH of Ukraine”,

DOI:

https://doi.org/10.14739/2310-1210.2019.4.173349

Keywords:

lower extremity, varicose vein, endothelium vascular

Abstract

 

The aim of the study is to examine the correlation between the endothelial dysfunction indices and the clinical class of the disease before and after the operation in patients with varicose disease of the lower extremities.

Materials and methods. In total, 69 patients with varicose disease of the lower extremities were examined, with preoperative and long-term postoperative measurements of homocysteine, nitrotyrosine and eNOS by the immunoassay analysis.

Results. The results of dynamic changes in endothelial dysfunction indices in 69 patients with varicose disease of the lower extremities, examined before and after an operation, were analyzed. A significant correlation between the mean values of homocysteine, nitrotyrosine and eNOS with the clinical class of lower extremity varicose vein disease (LEVVD) has been determined.

Conclusions. A significant decrease in the indices of homocysteine, nitrotyrosine and increased eNOS was observed long term following operation compared to the initial values before it. It has been established that the homocysteine values were relatively stronger correlated with the patient's age than with the LEVVD clinical class, and nitrotyrosine and eNOS were relatively higher correlated with the LEVVD class than with the patients’ age.

 

References

Shevchenko, Y. L., Stoyko, Y. M., Gudymovich, C. G., & Nikitina A. M. (2014). Disfunkcij e'ndoteliya v razvitii varikoznoj bolezni ven nizhnikh konechnostej i vozmozhnosti eyo korrekcii [Endothelial dysfunction in development of varicose veins of lower extremities and possibilities of it’s correction]. Medicinstkij vestnik Yuga Rossii, 4, 113–119. [in Russian]. https://doi.org/10.21886/2219-8075-2014-4-113-119

Bulayeva, N. I., & Golukhova, E. Z. (2013) E'ndotelial'naya disfunkciya I oksidantnyj stress: rol' v razvitii kardiovaskulyarnoj patologii [Endothelial dysfunction and oxidant stress: the role in cardiovascular pathology]. Kreativnaya kardiologiya, 1, 14–22. [in Russian].

Kravchun, N. A., & Chernyavskaya, I. V. (2016) E'ndotelial'naya disfunkciya pri sakharnom diabete: teoreticheskie i prakticheskie aspekty [Endothelial dysfunction in diabetes mellitus: theoretical and practical aspects]. Zdorov'ya Ukrainy, 1(33), 15–17. [in Russian].

Balatsky, A. V., Andreenko, E. Yu., Samokhodskaya, L. M., Boitsov, S. A., & Tkachuk, V. A. (2013) Polimorfizm genov e'ndotelial'noj NO-sintazy i konneksina-37 kak faktor riska razvitiya infarkta miokarda u lic bez koronarnogo anamneza [Endothelial NO synthase and connexin 37 gene polymorphisms as a risk factor for myocardial infarction in subjects without a history of coronary artery disease]. Terapevticheskij arkhiv, 9, 18–22. [in Russian].

Simonova, O. G., Kolobova, O. I., & Leshchenko, V. A. (2014) Regionarnye ortostaticheskie mekhanizmy e'ndotelial'noj disfunkcii pri varikoznoj bolezni [The regional orthostatic mechanisms of endothelial dysfunction associated with primary varicose veins]. Flebologiya, 4, 25–28. [in Russian].

Malakhova, S. М. (2016). Klinichni aspekty polimorfizmu hena endotelialnoi NO-syntazy u profesiinykh sportsmeniv [Clinical aspects of endothelial NO-synthase gene polymorphism in professional sportsmen]. Pathologia, 2(37), 98–104. [in Ukrainian]. doi: 10.14739/2310-1237.2016.2.80896 [in Ukrainian].

Okrut, I. E., Shakerova, D. A., & Veselova, T. A. (2012) E'ndotelial'naya disfunkciya i marker sosudisto-trombocitarnogo gemostaza pri metabolicheskom sindrome [Endothelial dysfunction and markers of vascular-platelet hemostasis in the metabolic syndrome]. Vestnik Nizhnegorodskogo universiteta im. N. I. Lobachevskogo, 2(3), 216–221. [in Russian].

Nikitina, A. M. (2014) E'ndotelial'naya disfunkciya v razvitii varikoznoj bolezni venn nizhnikh konechnostej i vozmozhnosti eyo korrekcii (Avtoref. dis…kand. med. nauk). [Endothelial dysfunction in the development of varicose veins of the lower extremities and the possibility of its correction] (Extended abstract of candidate’s thesis). Moscow. [in Russian].

Pfenniger, A., Derouette, J. P., Verma, V., Lin, X., Foglia, B., Coombs, W., et al. (2010) Gap junction protein Cx37 interacts with endothelial nitric oxide synthase in endothelial cells. Arterioscler Thromb Vasc Biol., 30(4), 827–834. doi: 10.1161/ATVBAHA.109.200816

Azizova, G., Dadashova, A., & Amirova, M. (2014) Biomarkery oksidativnogo stressa i sostoyanie antioksidantnoj sistemy pri sakharnom diabete tipa 2 [Biomarkers of oxidative stress and the state of antioxidant system in the present of type 2 diabetes mellitus]. Universum: Medicina i farmakologiya, 6(7), 1–9. [in Russian].

Förstermann, U., & Sessa, W. C. (2012) Nitric oxide synthases: regulation and function. Eur. Heart J., 33(7), 829–37. doi: 10.1093/eurheartj/ehr304

Okrut I.Ye., Dautova D.A. (2015) Oksid azota kak pokazatel' aktivnosti svobodnoradikal'nogo okisleniya pri metabolicheskom sindrome. [Nitric oxide as an indicator of the activity of free radical oxidation in metabolic syndrome]. Innovacionnaya nauka, 8–2(8), 132–135. [in Russian].

Skvortsov, Yu. I., & Korolkova, A. S. (2011) Gomocistein kak factor riska razvitiya IBS [Homocysteine as a risk factor of ischemic heart disease development (review)]. Saratovskij nauchno-medicinskij zhurnal, 7(3), 619–624. [in Russian].

Lazuko, S. S. (2016) Disfunkciya e'ndoteliya: e'ksperimental'nye i klinicheskie issledovaniya. Proceedings of the 9th International Scientific and Praktical Conference. Vitebsk. [in Russian].

Grebenchikov, O. A., Philippovskaya, Zh. S., Zabelina, T. S., Skripkin, Y. V., Ulitkina, O. N., & Likhvantsev, V. V. (2017) Opredelennye nitrotirozina ne pozvolyaet ocenit' stepen' vyrazhennosti oksidantnogo stressa i prognozirovat' veroyatnost' razvitiya rannikh oslozhnenij posleoperacionnogo perioda [Nitrotyrosine and its role in assessing the severity of oxidative stress and predicting the incidence of early postoperative complications]. Patologiya krovoobrashcheniya i kardiokhirurgiya, 21(2), 77–84 [in Russian]. doi: 10.21688-1681-3472-2017-2-77-84

Downloads

How to Cite

1.
Riazanov DY, Mamunchak OV. Dynamics of endothelial dysfunction indices before and after operation in patients with varicose disease of the lower extremities. Zaporozhye medical journal [Internet]. 2019Jul.15 [cited 2024Apr.19];(4). Available from: http://zmj.zsmu.edu.ua/article/view/173349

Issue

No. 4 (2019)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)