Pathogenetic role of vitamin D deficiency and immune-inflammatory disorders in development of fetal distress in pregnant women with chronic hydramnion

Authors

  • N. A. Haistruk National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • A. N. Haistruk National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • A. V. Melnyk National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • L. H. Dubas National Pirogov Memorial Medical University, Vinnytsia, Ukraine,
  • O. L. Lovkina National Pirogov Memorial Medical University, Vinnytsia, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2019.5.179436

Keywords:

vitamin D, hydramnion, fetal distress, cytokines

Abstract

 

The role of vitamin D deficiency and immune-inflammatory disorders in the mechanisms of fetal distress development in pregnant women with chronic polyhydramnios remains unstudied.

Objective: to evaluate the role of vitamin D deficiency and associated immune inflammatory disorders in the development of fetal distress in pregnant women with chronic polyhydramnios.

Materials and methods. In total, 30 women with a physiological course of pregnancy and 90 pregnant women with chronic polyhydramnios were examined. The serum levels of vitamin D metabolite (25 (OH)D) and cytokines IL-10 and IL-6 were determined by enzyme immunoassay using standard kits. Statistical processing of the obtained results was performed using standard methods with MS Excel and Statistica SPSS 10.0 for Windows application package.

Results. In pregnant women with chronic polyhydramnios, there is a significant decrease in the serum level of vitamin D metabolite 25 (OH)D by 21 % and anti-inflammatory cytokine IL-10 by 26.4 %, and an increase in the concentration of pro-inflammatory IL-6 by 17 % compared to women with physiological course of pregnancy. The occurrence of fetal distress in chronic polyhydramnios is accompanied by worsening of vitamin D deficiency and immune-inflammatory disorders: the levels of 25 (OH)D and IL-10 are 18.5 % and 17.5 % decreased, respectively, and IL-6 is 13.3 % increased than in women with chronic polyhydramnios without fetal distress. The intensity of immune disorders in pregnant women with chronic polyhydramnios is determined by the level of vitamin D in the organism. Thus, in women with 25 (OH)D deficiency, a significant decrease in serum IL-10 concentration by 47.8 % and a significant increase in IL-6 by 34.6  % were recorded in comparison with these indicators in women with vitamin D deficiency.

Conclusions. Vitamin D deficiency and associated immune-inflammatory disorders play an important role in the development of fetal distress in pregnant women with chronic polyhydramnios.

References

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How to Cite

1.
Haistruk NA, Haistruk AN, Melnyk AV, Dubas LH, Lovkina OL. Pathogenetic role of vitamin D deficiency and immune-inflammatory disorders in development of fetal distress in pregnant women with chronic hydramnion. Zaporozhye Medical Journal [Internet]. 2019Oct.1 [cited 2024Dec.24];(5). Available from: http://zmj.zsmu.edu.ua/article/view/179436

Issue

No. 5 (2019)

Section

Original research

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