Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease

Authors

  • L. M. Boiarska Zaporizhzhia State Medical University, Ukraine,
  • L. V. Hrebeniuk Zaporizhzhia State Medical University, Ukraine,
  • K. O. Ivanova Zaporizhzhia State Medical University, Ukraine,
  • V.V. Akhtyrsky Municipal Institution «Zaporizhzhia City Multi-field Children's Hospital No 5», Zaporizhzhia, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2019.5.179441

Keywords:

gastroesophageal reflux disease, chronic tonsillitis, children, preschool child, pathological gastroesophageal reflux, Haemophilus influenzae

Abstract

 

The aim was to study the condition of nasopharynx contamination in children with chronic tonsillitis depending on the presence of pathological gastro-esophageal reflux.

Materials and methods. In total, 44 children aged 4.60 ± 0.14 years were enrolled in the study. The index group comprised 22 people with chronic tonsillitis and gastroesophageal reflux disease (GERD); the control group consisted of 22 people with chronic tonsillitis but without GERD. Samples of nasopharynx secretion (pharyngeal and nasal swabs) were taken for culture and their results were analyzed. The results were statistically processed with the use of Microsoft Office Excel and Statistica 13 software.

Results. It was found that pharyngeal cultures obtained from children of the index group tended to reveal H. influenzae in the swab more frequently (in 77.3 %, P = 0.06). This microorganism was revealed in nasal cultures of children with GERD (in 31.8 %, P = 0.02) and only in mixed and acid reflux (30.0 % and 80.0 %, respectively). 63.6 % of children from the index group were culture positive for more than two microorganisms, which was typical for half of the children with mixed and acid reflux (13.6 %, P = 0.002). It was defined that children with GERD and colonized by H. influenzae, demonstrated higher rates of total quantity of acid reflux (193.86 ± 40.46 compared to 104.80 ± 2.06, P = 0.05), persistent acid reflux (7.50 ± 1.62 compared to 3.67 ± 1.20, P = 0.04), as well as percentage of acid reflux per day (26.17 ± 7.23 compared to 7.44 ± 2.06, P = 0.004).

Conclusions. Contamination of pharyngeal and nasal mucous membranes in children with GERD and chronic tonsillitis was represented by potentially pathogenic bacterial microflora (in 95.5 %) with the prevalence of H. influenzae. More than two microorganisms were revealed in children with mixed and acid reflux (P = 0.05). Children with GERD and chronic tonsillitis, provided H. influenzae colonization, demonstrated higher rates of total quantity of acid reflux (P = 0.05), persistent acid reflux (P = 0.04), as well as percentage of acid reflux per day (P = 0.004).

References

Chan, W.-Y., Cohen, J. M., & Brown, J. S. (2016). The new first-line defense: the potential of nasopharyngeal colonization in vaccine strategies. Centre for Inflammation and Tissue Repair, UCL Respiratory, Division of Medicine, University College London, 2016(6), 47–57. doi: https://doi.org/10.2147/VDT.S89026

Kamada, N., Chen, G. Y., Inohara, N., & Núñez, G. (2013). Control of Pathogens and Pathobionts by the Gut Microbiota. Nat Immunol., 14(7), 685–690. doi: 10.1038/ni.2608

Marushko, Yu. V., & Movchan, O. S. (2014) Sostoyanie mestnogo immuniteta i kharakteristika mikrobnogo pejzazha rotoglotki u detej s chastymi respiratornymi zabolevaniyami [State of the local immunity and characteristics of microflora of the oropharynx in children with recurrent respiratory infections]. Aktual'naya infektologiya, 1(2), 28–31. [in Russian].

Gorbachevskij, P. R., & Paramonova, N. S. (2016). Mikrobiocenoz slizistoj obolochki nosoglotki u chasto boleyuschikh detej i vozmozhnosti ego korrekcii [Microbiocenosis of the mucous membrane of the nasopharynx in frequently ill children and the possibility of its correction]. Semejnaya medicina, 2, 27–29. [in Russian].

Meshcheryakov, K. L. (2010). Citokiny i oksid azota pri khronicheskoj patologii limfoidnogo kol'ca glotki u detej (Avtoref. dis… dokt. med. nauk) [Cytokines and nitric oxide in chronic pathology of the lymphoid ring of the pharynx in children Dr. med. sci. diss.]. Moscow. [in Russian].

Busaba, N., & Doron, Sh. (2015) Tonsillectomy in adults: Indications. Retrieved from https://www.uptodate.com/contents/tonsillectomy-in-adults-indications?search=Tonsillectomy%20in%20adults:%20Indications&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1

Tulupov, D. A., & Karpova, E. P. (2014). O roli bakterial'noj mikroflory v etiologii khronicheskogo adenoidita u detej [On the role of bacterial microflora in etiology of chronic adenoiditis in children]. Voprosy sovremennoj pediatrii, 13(1), 172–175. doi: 10.15690/vsp.v13i1.930 [in Russian].

Epanchinceva, A. S. (2010) Faktor vysokogo gastroe'zofageal'nogo refljuksa v razvitii razlichnykh form khronicheskogo faringita (Avtoref. dis… dokt. med. nauk) [Factor of high gastroesophageal reflux in the development of various forms of chronic pharyngitis Dr. med. sci. diss.] Moscow. [in Russian].

Yüksel, F., Doğan, M., Karataş, D., Yüce, S., Şentürk, M., & Külahlı İ. (2013). Clinical presentation of gastroesophageal reflux disease in children with chronic otitis media with effusion. J Craniofac Surg., 24(2), 380–383. doi: 10.1097/SCS.0b013e31827feb08

Kosyakov, S. Ya., Loranskaya, I. D., Angotoeva, I. B., & Muldasheva, A. A. (2016). Osobennosti diagnosticheskogo obsledovaniya i lecheniya khronicheskogo tonzillita u pacientov na fone laringofaringeal'nogo refliuksa [Features of diagnostic tests and treatment of chronic tonsillitis in patients against the background of laryngopharyngeal reflux]. Lechashchij vrach, 6, 89–91. [in Russian].

Karpova, E. P., & Tulupov, D. A. (2013). O roli razlichnykh e'tiologicheskikh faktorov v razvitii khronicheskoj patologii nosoglotki u detej [On the meaning of different etiological factors in the development of chronic pathology of nasopharynx in children]. Lechashchij vrach, 1, 26–28. [in Russian].

Chen, H. X., Lai, C. H., Hsu, H. Y., Huang, J. C., Wu, H. S., Ho, M. W., et al. (2015). The bacterial interactions in the nasopharynx of children receiving adenoidectomy. Biomedicine (Taipei), 5(1), 6. doi: 10.7603 / s40681-015-0006-9

Khrustaleva, E. V., Pedder, V. V., Shishkina, N. M., & Lubyanskaya, T. G. (2013). Vzaimosviaz' urovnya pH slizistoj obolochki rotoglotki i nalichiya gribkovoj flory u bol'nykh GE'RB [Interrelation of pH level of mucous membrane of stomatopharynx and mucology existence at patients with gerd]. Medicina i obrazovanie v Sibiri, 6, 36. [in Russian].

Yaravy, I. Y. & Butsel, A. Th. (2016). Mikroflora slizistoj obolochki glotki pri faringitakh u pacientov s proyavleniem gastroe'zofageal'nogo reflyuksa bolezni [Microflora of the mucous membrane of the pharynx with chronic pharyngitis caused by gerd]. Medicinskij zhurnal, 2, 129–132. [in Russian].

Lezhenko, H. O., Abaturov, O. Ye., & Pashkova, O. Ye. (2016). Rol endohennykh antymikrobnykh peptydiv u bakterialnii kolonizatsii nosohlotky v ditei iz hiperplaziieiu retronazalnoi myhdalyny [The role of endogenous antimicrobial peptides in the bacterial colonization of the nasopharynx in children with hyperplasia of the pharyngeal tonsil]. Zdorov'e rebenka, 6(74), 74–79. [in Ukrainian].

Alasil, S. M., Omar, R., Ismail, S., Yusof, M. Y., Dhabaan, Gh. N., & Abdulla M. A. (2013). Evidence of Bacterial Biofilms among Infected and Hypertrophied Tonsils in Correlation with the Microbiology, Histopathology, and Clinical Symptoms of Tonsillar Diseases. Int J Otolaryngol., 2013. doi: 10.1155/2013/408238

Downloads

How to Cite

1.
Boiarska LM, Hrebeniuk LV, Ivanova KO, Akhtyrsky V. Condition of nasopharynx contamination in children with chronic tonsillitis and gastroesophageal reflux disease. Zaporozhye Medical Journal [Internet]. 2019Oct.1 [cited 2024Jul.23];(5). Available from: http://zmj.zsmu.edu.ua/article/view/179441

Issue

No. 5 (2019)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)