Interrelationship between circulating vascular еndothelial growth factor-1 and high-sensitive C-reactive protein in stage III arterial hypertension patients
DOI:
https://doi.org/10.14739/2310-1210.2013.5.18768Keywords:
vascular endothelial growth factor-1, high sensitive C-reactive protein, arterial hypertension, ischemic strokeAbstract
Introduction. Arterial hypertension is one of the most important causes of mortality in the world. Vascular endothelial growth factor-1 (VEGF-1) pathways are the most frequently involved in hypertension development, especially related cardiovascular remodelling. On the other hand, many retrospective studies have suggested a relationship between cardiovascular risk in antihypertensive patients and VEGF-1. However, an impact of VEGF-1 in hypertensive subjects after ischemic stroke is still uncertain. High sensitive C-reactive protein (hs-CRP) is considered as a sensitive indicator of systemic inflammation and direct mediator of atherogenesis that has been shown to be a powerful predictor of future recurrent coronary and cerebral ischemic events in subjects after stroke. However, the pathogenic and clinical significance of these associations is controversial.
Objective. To evaluate the relationship between circulating vascular endothelial growth factor-1 level and high sensitive C-reactive protein (hs-CRP) in III stage arterial hypertension patients.
Methods. 102 mild-to-moderate arterial hypertension patients were enrolled to the study in 3 weeks after ischemic stroke. Circulating vascular endothelial growth factor-1 level and hs CRP were determined at study entry only.
Results. Analysis of obtained outcomes have been showed that circulating VEGF-1 is independently associated with the hsC-RP (R = 0.478; P = 0.001), type 2 diabetes (R = 0.422; P = 0.001) and hyperlipidemia (R = 0.413; P = 0.002), male gender (R = 0.407; P = 0.001), BMI (R = -0.422; P = 0.001), statins using (R = -0.411; P = 0.001), treatment of ACE inhibitor (R = -0.403; P = 0.001), triglycerides concentration (R = -0.356; P = 0.002). In this case, the circulating VEGF-1 increases non-linearly proportional to the quartiles of the hs CRP quartile level in the blood.
In conclusion, we found that concentration of high-sensitivity C-reactive protein above 10.57 mg/l might be an indicator of vascular endothelial growth factor-1 elevation in hypertensive patients irrespective of traditional cardiovascular risk factors.
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