Relationship between hyperferritinemia and clinical manifestations of gout

Authors

  • H. P. Kuzmina SI “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”, Kryvyi Rih,
  • O. M. Lazarenko SI “Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine”, Kryvyi Rih,

DOI:

https://doi.org/10.14739/2310-1210.2020.1.194480

Keywords:

iron metabolism, inflammation, comorbidity, gout

Abstract

 

Aim. To study the parameters of ferritin, uric acid in the serum and urine, high-sensitivity C-reactive protein (hsCRP) in patients with hypertension in combination with gout and the relationship between these data and clinical manifestations of gout.

Materials and methods. 61 patients with hypertension, middle age of whom amounted to 54.25 (10.29) years, had been surveyed, 39 (64 %) men and 22 (36 %) women. All patients were divided into two groups: the main group – 36 patients with hypertension in combination with gout and the comparison group – 25 patients with hypertension without gout.

Determination of ferritin level in serum was carried out by using an immunochemical method with electrochemiluminescence detection (Cobas 6000 analyzer, Roche Diagnostics test system,Switzerland). Colorimetric analysis was used to determine the concentration of serum uric acid, the spectrophotometric method – of uric acid in urine, the immunoassay method – of hsCRP.

Results. The average serum uric acid level significantly differed (P = 5.4 E-5) in the main group and the comparison group and was 443.44 (129.66) μmol/L and 317.16 (77.60) μmol/L, respectively. The level of ferritin in the main group was significantly higher (237 (237; 247), P = 4.3 E-5 ng/mL) than in the comparison group (137 (83,23; 137) ng/mL), as well as the level of hsCRP (P = 4.4 E-6) 11.78 (3.70; 12.66) mg/L and 1.07 (0; 3.82) mg/L, respectively. The level of uric acid in urine was not significantly different (P = 0.23) in both groups and amounted to 2470.92 (836.89) μmol/L in the main group and 2198.00 (881.73) μmol/L in the comparison group.

A significant correlation (r = 0.30; P < 0.05) was found between the levels of serum uric acid and ferritin in the main group patients, as well as a significant correlation between the levels of serum uric acid and the duration of gout (r = 0.41; P < 0.05), the total number of affected joints (r = 0.51; P < 0.05), gout severity (r = 0.36; P < 0.05), the level of ferritin and the number of gout exacerbation (r = 0.31; P < 0.05).

Conclusions. Elevated serum ferritin concentration increases the risk of gouty arthritis exacerbation. Establishing the relationship between the concentration of ferritin and serum levels of uric acid and the number of gout exacerbations in the main group suggests that iron plays an important role in the disease pathogenesis.

References

Singh, J. (2017). Gout and comorbidity: a nominal group study of people with gout. Arthritis Research & Therapy, 19(1), Article 204. https://doi.org/10.1186/s13075-017-1416-8

Malta, D., Gonçalves, R., Machado, Í., Freitas, M., Azeredo, C., & Szwarcwald, C. (2018). Prevalência da hipertensão arterial segundo diferentes critérios diagnósticos, Pesquisa Nacional de Saúde [Prevalence of arterial hypertension according to different diagnostic criteria, National Health Survey]. Revista Brasileira De Epidemiologia, 21(suppl. 1), Article e180021. https://doi.org/10.1590/1980-549720180021.supl.1 [in English, Portuguese].

Flais, J., Bardou-Jacquet, E., Deugnier, Y., Coiffier, G., Perdriger, A., Chalès, G., Ropert, M., Loréal, O., & Guggenbuhl, P. (2017). Hyperferritinemia increases the risk of hyperuricemia in HFE-hereditary hemochromatosis. Joint Bone Spine, 84(3), 293 297. https://doi.org/10.1016/j.jbspin.2016.05.020

Fatima, T., Merriman, T. R., Stamp, L. K., Dalbeth, N., Iverson, C., & Miner, J. N. (2016). Ferritin Levels Are Associated with Urate and Gout – a Role for Iron Metabolism in Gout? [abstract]. Arthritis Rheumatol, 68(suppl. 10). Retrieved from https://acrabstracts.org/abstract/ferritin-levels-are-associated-with-urate-and-gout-a-role-for-iron-metabolism-in-gout/.

Fatima, T., McKinney, C., Major, T. J., Stamp, L. K., Dalbeth, N., Iverson, C. Merriman, T. R., & Miner, J. N. (2018). The relationship between ferritin and urate levels and risk of gout. Arthritis Research & Therapy, 20(1), 179. https://doi.org/10.1186/s13075-018-1668-y

Mainous, A., Knoll, M., Everett, C., Matheson, E., Hulihan, M., & Grant, A. (2011). Uric Acid as a Potential Cue to Screen for Iron Overload. The Journal Of The American Board Of Family Medicine, 24(4), 415 421. https://doi.org/10.3122/jabfm.2011.04.110015

Downloads

How to Cite

1.
Kuzmina HP, Lazarenko OM. Relationship between hyperferritinemia and clinical manifestations of gout. Zaporozhye Medical Journal [Internet]. 2020Feb.10 [cited 2024Nov.23];22(1). Available from: http://zmj.zsmu.edu.ua/article/view/194480

Issue

Vol. 22 No. 1 (2020)

Section

Original research

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)