The role of interleukin-10 and its encoding gene polymorphism influence on the course of infections caused by varicella-zoster virus
Keywords:chickenpox, herpes zoster, interleukin-10, genetic polymorphism
The purpose is to find out the role of changes in the quantitative content of IL-10 in association with the polymorphism of gene encoding it (rs 1800872) in the course of chickenpox and herpes zoster.
Materials and methods. The study included 50 adult patients with chicken pox and 50 patients with herpes zoster. The analysis of the quantitative serum content of IL-10 depending on the genetic polymorphism of this cytokine (rs 1800872) and the effect on the disease course was carried out. The quantitative serum content of IL-10 was determined by enzyme immunoassay, the determination of single nucleotide polymorphism of IL-10 (rs 1800872) in whole venous blood of patients was performed by real-time polymerase chain reaction. The control group consisted of 40 healthy individuals. Statistical data processing was performed using the existing patient database with the application of Statistica for Windows 13 program (StatSoft Inc., No JPZ804I382130ARCN10-J).
Results. The TT genotype of the IL-10 gene (rs 1800872) was found to be associated with severe varicella (P = 0.04) and herpes zoster (P = 0.01) in adults. In chickenpox patients, the TT genotype was associated with the development of hepatitis (χ2 = 6.17, P = 0.01). In patients with herpes zoster, the TT genotype had an impact on the development of neurological (P = 0.03) and ophthalmic complications (P = 0.0001). Secondary bacterial complications were associated with the TG genotype of the IL-10 gene (rs 1800872) carrier state in all the patients (P < 0.05). It was proved that TT genotype was associated with an increase in serum IL-10 concentration (rs 1800872) in all the patients with infections caused by varicella-zoster virus on admission. In the course of the disease, the quantitative content of IL-10 decreased in all patients with the TT genotype, but remained elevated at the time of discharge (P < 0.05). In patients with chickenpox, the TG genotype carriage caused only an increasing trend in the serum IL-10 concentration not different from that in healthy individuals (P < 0.05). At the same time, in patients with herpes zoster, the TG genotype of the IL-10 gene (rs 1800872) was associated with an increased cytokine content both on admission and in the disease dynamics (P < 0.05).
Conclusions. Changes in the serum concentration of IL-10 in patients with infections caused by varicella-zoster virus depend on the polymorphism of the IL-10 gene (rs 1800872) that encodes it, and are associated with certain clinical features of chickenpox and herpes zoster.
Wutzler, P., Bonanni, P., Burgess, M., Gershon, A., Sáfadi, M. A., & Casabona, G. (2017). Varicella vaccination - the global experience. Expert Review of Vaccines, 16(8), 833–843. https://doi.org/10.1080/14760584.2017.1343669
Word Heals Organization. (2014). Varicella and herpes zoster vaccines: WHO position paper, 20 June 2014. Weekly Epidemiological Record, 89(25), 265-87. https://www.who.int/wer/2014/wer8925/en/
Popescu, C. P., Ceausu, E., Florescu, S. A., Chirita, D., & Ruta, S. (2016). Complications of Varicella in Unvaccinated Children From Romania, 2002–2013: A Retrospective Study. The Pediatric Infectious Disease Journal, 35(2), 211–212. https://doi.org/10.1097/inf.0000000000000969
Nezghoda, I. I., & Levytska, L. I. (2017). Vitriana vispa u ditei [Chickenpox in children]. Infektsiini khvoroby, 1(87), 60-70. https://doi.org/10.11603/1681-2727.2017.1.7786 [in Ukrainian].
Hussey, H. S., Abdullahi, L. H., Collins, J. E., Muloiwa, R., Hussey, G. D., & Kagina, B. M. (2016). Varicella zoster virus-associated morbidity and mortality in Africa: a systematic review protocol. BMJ Open, 6(4), Article e010213. https://doi.org/10.1136/bmjopen-2015-010213
Kennedy, P., & Gershon, A. (2018). Clinical Features of Varicella-Zoster Virus Infection. Viruses, 10(11), Article e609. https://doi.org/10.3390/v10110609
Nakajima, H., Hara, M., Morita, A., & Kamei, S. (January 17th 2019). Neurologic Complications of Varicella-Zoster Virus Infection. IntechOpen, https://doi.org/10.5772/intechopen.83036
Kramarev, S. A., Vygovskaya, O. V., Deyev, V. V., Moshich, A. P., Melnikov, O. F., Shashkina, A. V., Nadvorskaya, Yu. Ye., Pilipenko, O. S., Kolinko, T. A., & Godvin, U. (2014). Vetryanaya ospa u detei: osobennosti lecheniya [Chickenpox in Children: Features of Treatment]. Zdorov'e rebenka, (6), 33-37. [in Russian].
Koshy, E, Mengting, L., Kumar, H., & Jianbo, W. (2018). Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian Journal of Dermatology, Venereology and Leprology, 84(3), 251 262. https://doi.org/10.4103/ijdvl.ijdvl_1021_16
Liu, Y. (2015). Advances in Epidemiological Studies of Herpes Zoster. Infection International, 4(4), 116–120. https://doi.org/10.1515/ii-2017-0119
Hao, M., Wang, X., Du, J., Liu, L., Jiao, Y., Wu, H., Zheng, J., & Li, W. (2015). Cytokine levels are associated with the severity of varicella infections. The Journal of Infection in Developing Countries, 9(02), 190–196. https://doi.org/10.3855/jidc.5255
Leung, J., Broder, K. R., & Marin, M. (2017). Severe varicella in persons vaccinated with varicella vaccine (breakthrough varicella): a systematic literature review. Expert Review of Vaccines, 16(4), 391–400. https://doi.org/10.1080/14760584.2017.1294069
Puzyryova, L. V., & Safonov, A. D. (2016). Geneticheskii polimorfizm tsitokinov: proshloe i budushchee [Cytokines genetic polymorphism: the past and the future]. Infektsiya i immunitet, 6(2), 103 108. https://doi.org/10.15789/2220-7619-2016-2-103-108 [in Russian].
Rojas, J. M., Avia, M., Martín, V., & Sevilla, N. (2017). IL-10: A Multifunctional Cytokine in Viral Infections. Journal of Immunology Research, 2017, Article 6104054. https://doi.org/10.1155/2017/6104054
Usychenko, E. N., Usychenko, E. M., & Bazhora, Yu. I. (2017). Analiz assotsiatsii polimorfizma genov tsitokinov IL-4, IL-10 i TNF s biokhimicheskimi i immunologicheskimi pokazatelyami u bol'nykh khronicheskim gepatitom C [The analysis of association of polymorphism of IL-4, IL-10 and TNF cytokine genes with biochemical and immunological indicators in patients with chronic hepatitis C]. Aktualna infektolohiia, 5(7), 277-281. https://doi.org/10.22141/2312-413x.5.6.2017.122141 [in Russian].
Romanova, E. N., & Govorin, A. V. (2015). Geneticheskie osobennosti u bol'nykh grippom A / H1N1 / 09, oslozhnennym pnevmoniei [Genetic features of patients with influenza A / H1N1 / 09 complicated by pneumonia]. Russian Pulmonology, 25(4), 425 432. https://doi.org/10.18093/0869-0189-2015-25-4-425-432 [in Russian].
Moraru, M., Cisneros, E., Gómez-Lozano, N., de Pablo, R., Portero, F., Cañizares, M., Vaquero, M., Roustán, G., Millán, I., López-Botet, M., & Vilches, C. (2012). Host Genetic Factors in Susceptibility to Herpes Simplex Type 1 Virus Infection: Contribution of Polymorphic Genes at the Interface of Innate and Adaptive Immunity. The Journal of Immunology, 188(9), 4412–4420. https://doi.org/10.4049/jimmunol.1103434
Onishchenko, N. V., Riabokon, Yu. Yu., & Riabokon, O. V. (2018). The role of interleukin-10 gene polymorphism (rs 1800872) in the course of herpes zoster in adults. Pathologia, 15(3), 325 329. https://doi.org/10.14739/2310-1237.2018.3.151810
Hoppe, F. M., Hoppe, D. J., & Walter, S. D. (2018). Explaining odds ratios as conditional risk ratios. Journal of Clinical Epidemiology, 97, 123–124. https://doi.org/10.1016/j.jclinepi.2017.10.009
Freer, G., & Pistello, M. (2018). Varicella-zoster virus infection: natural history, clinical manifestations, immunity and current and future vaccination strategies. New Microbiologica, 41(2), 95 105. http://www.newmicrobiologica.org/PUB/allegati_pdf/2018/2/95.pdf
Nussbaum, R. (2014). Theories on Varicella Zoster Virus Reactivation Based on Shingles Patterns. The Science Journal of the Lander College of Arts and Sciences, 8(1). https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1082&context=sjlcas
Trifunović, J., Miller, L., Debeljak, Ž., & Horvat, V. (2015). Pathologic patterns of interleukin 10 expression – A review. Biochemia Medica, 25(1), 36–48. https://doi.org/10.11613/bm.2015.004
Shi, H.-J., & Cui, Z.-Q. (2017). Correlation of serum inflammatory cytokine and immunoglobulin content with post-herpetic neuralgia in patients with acute herpes zoster. Journal of Hainan Medical University, 23(1), 97 100. http://www.hnykdxxb.com/PDF/201701/26.pdf.
Zheleznikova, G. F., Lobzin, Y. V., Skripchenko, N. V., Ivanova, G. P., Skripchenko, E. Y., & Monakhova, N. E. (2015). Klinicheskoe znachenie syvorotochnykh urovnei tsitokinov pri vetryanoi ospe u detei [Clinical significance of cytokines serum levels in children with chicken pox]. Infektsiya i immunitet, 5(1), 79 84. https://doi.org/10.15789/2220-7619-2015-1-79-84 [in Russian].
Simon, A. K., Hollander, G. A., & McMichael, A. (2015). Evolution of the immune system in humans from infancy to old age. Proceedings of the Royal Society B: Biological Sciences, 282(1821), Article 20143085. https://doi.org/10.1098/rspb.2014.3085
Haanpää, M., Nurmikko, T., & Hurme, M. (2002). Polymorphism of the IL-10 Gene is Associated with Susceptibility to Herpes Zoster. Scandinavian Journal of Infectious Diseases, 34(2), 112–114. https://doi.org/10.1080/00365540110077218
Cho, J.-W., Shin, D.-H., & Lee, K.-S. (2007). Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster in Korea. Journal of Dermatological Science, 45(3), 213–215. https://doi.org/10.1016/j.jdermsci.2006.11.004
Beltra, J.-C., & Decaluwe, H. (2016). Cytokines and persistent viral infections. Cytokine, 82, 4–15. https://doi.org/10.1016/j.cyto.2016.02.006
How to Cite
LicenseAuthors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)