Use of bacterial drugs for allergic diseases treatment: pros and cons
DOI:
https://doi.org/10.14739/2310-1210.2020.1.194664Keywords:
hypersensitivity, allergic diseases, microbiota, probiotics, prebiotics, hygiene theoryAbstract
The purpose of this work is to establish the main arguments for expediency and inexpediency of bacterial drugs use in allergic pathology treatment based on the literary sources analysis.
In recent years, the most popular topic of scientific discussion is the bacterial drugs use for various diseases treatment, including allergic pathology. Numerous studies have confirmed the important role of microbiota in the immune system development and function as well as in allergic diseases occurrence. It is quite predictable that bacterial drugs use in this case is pathogenetically substantiated and should be effective. Currently, a large number of publications demonstrate the efficient use of bacterial agents in the treatment and prevention of allergic diseases in experimental conditions. However, despite promising experimental studies, the reliable clinical evidence of the probiotics efficacy in allergic diseases treatment does not exist. Few scientific publications evidencing the moderate probiotics efficacy in atopic dermatitis treatment have not been confirmed in large-scale meta-analyses. Some reports inform about an adverse effect of bacterial drugs on the course of allergic diseases. Therefore, these medications can not be used today as drugs for the pathogenetic treatment of allergic diseases, but have found a use as additional medicinal agents or nutritional supplements.
Conclusions. Taking into account the results of many scientific papers, we can confirm the relationship between allergic diseases and the microbiota state. Even so, effective influence of probiotics on an allergy course has not been proved. An impact on risk factors would be more appropriate, in particular, breastfeeding promotion, lifestyle modification and rational nutrition. This approach may be simple and effective.
References
Boyarchuk, O., Chornomydz, A., Chornomydz, I., Krytska, H., & Horishniy, I. (2019). The role of microbiota in the development of allergic diseases. Health Problems of Civilization, 13(2), 135–146. https://doi.org/10.5114/hpc.2019.83300
Pukhlyk, B. M., Dytiatkivska, Ye. M., Hohunska, I. V., & Kholodenko, T. Yu. (2012). Pytannia poshyrenosti ta ekonomichnoi efektyvnosti likuvannia alerhiinykh zakhvoriuvan orhaniv dykhannia v Ukraini [Prevalence studies and economic efficiency of treatment of allergic diseases of the respiratory organs in Ukraine]. Klinichna immunolohiia. Alerholohiia. Infektolohiia, (special issue 2), 5 7. [in Ukrainian].
Toh, Z. Q., Anzela, A., Tang, M. L. K., & Licciardi, P. V. (2012). Probiotic Therapy as a Novel Approach for Allergic Disease. Frontiers in Pharmacology, 3, Article 171. https://doi.org/10.3389/fphar.2012.00171
Kaliuzhna, L. D., Oshivalova, O. O., Boychuk, A. M., & Reznikova, A. A. (2011). Pohliad na likuvannia alerhodermatoziv [Treatment of allergic dermatoses]. Ukrainskyi zhurnal dermatolohii, venerolohii, kosmetolohii, (4), 56 60. [in Ukrainian].
Hendaus, M., Jomha, F., & Ehlayel, M. (2016). Allergic diseases among children: nutritional prevention and intervention. Therapeutics and Clinical Risk Management, 12, 361–372. https://doi.org/10.2147/tcrm.s98100
Roży, A., Jaguś, P., & Chorostowska-Wynimko, J. (2012). Rola probiotyków w profilaktyce i leczeniu chorób alergicznych [Probiotics in the prevention and treatment of allergic diseases]. Pneumonologia i Alergologia Polska, 80(1), 65–76. [in Polish].
Tanaka, M., & Nakayama, J. (2017). Development of the gut microbiota in infancy and its impact on health in later life. Allergology International, 66(4), 515–522. https://doi.org/10.1016/j.alit.2017.07.010
Waligora-Dupriet, A.-J., & Butel, M.-J. (2012). Microbiota and Allergy: From Dysbiosis to Probiotics. In C. Pereira (Ed.), Allergic Diseases – Highlights in the Clinic, Mechanisms and Treatment (pp. 413 434). IntechOpen. https://doi.org/10.5772/26234
Bloomfield, S. F., Rook, G. A., Scott, E. A., Shanahan, F., Stanwell-Smith, R., & Turner, P. (2016). Time to abandon the hygiene hypothesis: new perspectives on allergic disease, the human microbiome, infectious disease prevention and the role of targeted hygiene. Perspectives in Public Health, 136(4), 213–224. https://doi.org/10.1177/1757913916650225
Geddes, L. (2016, July 8). We need a new approach to avoiding allergies. BBC.FUTURE. https://www.bbc.com/future/article/20160708-we-need-a-new-approach-to-avoiding-allergies
Bengmark, S. (2013). Gut microbiota, immune development and function. Pharmacological Research, 69(1), 87–113. https://doi.org/10.1016/j.phrs.2012.09.002
Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012). Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature, 482(7385), 395–399. https://doi.org/10.1038/nature10772
Barczyńska, R., Śliżewska, K., Libudzisz, Z., & Litwin M. (2013). Rola mikrobioty jelit w utrzymaniu prawidłowej masy ciała [The role of intestinal microorganisms to maintain a healthy body weight]. Standardy medyczne/Pediatria, 1, 55 62. [in Polish].
Jandhyala, S. M., Talukdar, R., Subramanyam, C., Vuyyuru, H., Sasikala, M., & Nageshwar Reddy, D. (2015). Role of the normal gut microbiota. World Journal of Gastroenterology, 21(29), 8787-8803. https://doi.org/10.3748/wjg.v21.i29.8787
Lapshin, О., & Odinets, М. (2014). Kyshkova mikroflora: vplyv na zdorov’ia liudyny [Intestinal Microflora: Health Effects]. Liky Ukrainy, (7 8), 30 33. [in Ukrainian].
Szachta, P., Bartnicka, A., & Gałęcka, M. (2016). Microbiota – a key to healing the gastrointestinal tract? Pomeranian Journal of Life Sciences, 62(1), 21 24.
Tkach, S., Tymoshenko, O., & Dorofeyeva, А. (2016). Rol kyshkovoi mikrobioty u rozvytku ozhyrinnia ta insulinorezystentnosti [Involment of gut microboita in the development of obesity and insulin resistance]. Klinichna endokrynolohiia ta endokrynna khirurhiia, (1), 7 16. https://doi.org/10.24026/1818-1384.1(53).2016.75590 [in Ukrainian].
Di Mauro, A., Neu, J., Riezzo, G., Raimondi, F., Martinelli, D., Francavilla, R., & Indrio, F. (2013). Gastrointestinal function development and microbiota. Italian Journal of Pediatrics, 39, 15. https://doi.org/10.1186/1824-7288-39-15
Peterson, L. W., & Artis, D. (2014). Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nature Reviews Immunology, 14(3), 141–153. https://doi.org/10.1038/nri3608
Holt, P. G., & Sly, P. D. (2007). Prevention of allergic respiratory disease in infants: current aspects and future perspectives. Current Opinion in Allergy and Clinical Immunology, 7(6), 547–555. https://doi.org/10.1097/aci.0b013e3282f14a17
Riiser, A. (2015). The human microbiome, asthma, and allergy. Allergy, Asthma & Clinical Immunology, 11(35). https://doi.org/10.1186/s13223-015-0102-0
Bridgman, S. L., Kozyrskyj, A. L., Scott, J. A., Becker, A. B., & Azad, M. B. (2016). Gut microbiota and allergic disease in children. Annals of Allergy, Asthma & Immunology, 116(2), 99–105. https://doi.org/10.1016/j.anai.2015.10.001
Belkaid, Y., & Hand, T. W. (2014). Role of the Microbiota in Immunity and Inflammation. Cell, 157(1), 121–141. https://doi.org/10.1016/j.cell.2014.03.011
Romagnani, S. (2006). Regulation of the T cell response. Clinical & Experimental Allergy, 36(11), 1357–1366. https://doi.org/10.1111/j.1365-2222.2006.02606.x
Akdis, M. (2006). Healthy immune response to allergens: T regulatory cells and more. Current Opinion in Immunology, 18(6), 738–744. https://doi.org/10.1016/j.coi.2006.06.003
Gregorczyk-Maślanka, K., Kurzawa, R. (2016). Mikrobiota organizmu ludzkiego i jej wpływ na homeostazę immunologiczną – część I [Human microbiota. The impact on immune homeostasis – part I]. Alergia Astma Immunologia, 21(3), 146 150. [in Polish].
Noval Rivas, M., Burton, O. T., Wise, P., Charbonnier, L.-M., Georgiev, P., Oettgen, H. C., Rachid, R., & Chatila, T. A. (2015). Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy. Immunity, 42(3), 512–523. https://doi.org/10.1016/j.immuni.2015.02.004
Kalliomäki, M. (2009). Le rôle du microbiote dans l’allergie [The Role of Microbiota in Allergy]. Annales Nestlé (Ed. Française), 67(1), 19–26. https://doi.org/10.1159/000222312 [in French].
Lee, J.-B., Chen, C.-Y., Liu, B., Mugge, L., Angkasekwinai, P., Facchinetti, V., Dong, C., Liu, Y.-J., Rothenberg, M. E., Hogan, S. P., Finkelman, F. D., & Wang, Y.-H. (2016). IL-25 and CD4 + TH2 cells enhance type 2 innate lymphoid cell–derived IL-13 production, which promotes IgE-mediated experimental food allergy. Journal of Allergy and Clinical Immunology, 137(4), 1216 1225.e5. https://doi.org/10.1016/j.jaci.2015.09.019
Penders, J., Gerhold, K., Thijs, C., Zimmermann, K., Wahn, U., Lau, S., & Hamelmann, E. (2014). New insights into the hygiene hypothesis in allergic diseases. Gut Microbes, 5(2), 239–244. https://doi.org/10.4161/gmic.27905
Wesemann, D. R., & Nagler, C. R. (2016). The Microbiome, Timing, and Barrier Function in the Context of Allergic Disease. Immunity, 44(4), 728–738. https://doi.org/10.1016/j.immuni.2016.02.002
Geuking, M. B., Cahenzli, J., Lawson, M. A. E., Ng, D. C. K., Slack, E., Hapfelmeier, S., McCoy, K. D., & Macpherson, A. J. (2011). Intestinal Bacterial Colonization Induces Mutualistic Regulatory T Cell Responses. Immunity, 34(5), 794–806. https://doi.org/10.1016/j.immuni.2011.03.021
Fujimura, K. E., & Lynch, S. V. (2015). Microbiota in Allergy and Asthma and the Emerging Relationship with the Gut Microbiome. Cell Host & Microbe, 17(5), 592–602. https://doi.org/10.1016/j.chom.2015.04.007
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., Takahashi, M., Fukuda, N. N., Murakami, S., Miyauchi, E., Hino, S., Atarashi, K., Onawa, S., Fujimura, Y., Lockett, T., … Ohno, H. (2013). Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature, 504(7480), 446–450. https://doi.org/10.1038/nature12721
Durkin, H. G., Bazin, H., & Waksman, B. H. (1981). Origin and fate of IgE-bearing lymphocytes. I. Peyer’s patches as differentiation site of cells. Simultaneously bearing IgA and IgE. The Journal of Experimental Medicine, 154(3), 640–648. https://doi.org/10.1084/jem.154.3.640
Osborn, D. A., & Sinn, J. K. (2013). Prebiotics in infants for prevention of allergy. Cochrane Database of Systematic Reviews, (3). https://doi.org/10.1002/14651858.CD006474.pub3
Szczepankiewicz, A. (2017). Rola mikrobiomu w chorobach alergicznych [The role of microbiome in allergy]. Alergia, (1), 5 8.
Anukam, K. C., & Reid, G. (2007). Probiotics: 100 years (1907-2007) after Elie Metchnikoff's Observations. In A. Méndez-Vilas (Ed.), Communicating Current Research and Educational Topics and Trends in Applied Microbiology (pp. 466 474). Badajoz: FORMATEX 2007. https://pdfs.semanticscholar.org/b91e/475ffa4153383dc3734621c9c09c449999a9.pdf
Kalinichenko, S. V., Korotkykh, O. O., & Tishchenko, I. Yu. (2016). Suchasni napriamky stvorennia ta udoskonalennia probiotykiv [The topical areas of creation and improvement of probiotics (review)]. Ukrainskyi biofarmatsevtychnyi zhurnal, (1), 4 10. [in Ukrainian].
(2012). Probiotiki i prebiotiki. Obshchie prakticheskie rekomendatsii Vsemirnoi gastroenterologicheskoi organizatsii (2011) [Probiotics and prebiotics. General practical recommendations of the World Gastroenterological Organization (2011)]. Liky Ukrainy, (7), 34 43. [in Russian].
Marushko, Iu. V., & Asonov, A. O. (2018). Obgruntuvannia zastosuvannia synbiotyka Optilakt Maliuk® u pediatrychnii praktytsi [Justification of the use of the synbiotic Optilact Maluk in pediatric practice]. Mizhnarodnyi zhurnal pediatrii, akusherstva ta hinekolohii, 12(1), 43 50. [in Ukrainian].
Kordon, T. I. (2014). Pryntsypy stvorennia, mekhanizm dii ta klinichne zastosuvannia probiotykiv (Ohliad) [Creation principles, mechanism of action and clinical application of probiotics (review)]. Annals of Mechnikov Institute, (2), 8 16. [in Ukrainian].
Kornienko, E. A. (2015). Mikrobiota kishechnika i vozmozhnosti probioticheskoi terapii pri vospalitel'nykh zabolevaniyakh kishechnika [Intestinal microbiota and potentials for the probiotic therapy in inflammatory bowel diseases]. Farmateka, (2), 39 43. [in Russian].
Rachid, R., & Chatila, T. A. (2016). The role of the gut microbiota in food allergy. Current Opinion in Pediatrics, 28(6), 748–753. https://doi.org/10.1097/mop.0000000000000427
Huang, Y. J., Marsland, B. J., Bunyavanich, S., O’Mahony, L., Leung, D. Y. M., Muraro, A., & Fleisher, T. A. (2017). The microbiome in allergic disease: Current understanding and future opportunities 2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. Journal of Allergy and Clinical Immunology, 139(4), 1099–1110. https://doi.org/10.1016/j.jaci.2017.02.007
Heng, N. C. K., Haji-Ishak, N. S., Kalyan, A., Wong, A. Y. C., Lovrić, M., Bridson, J. M., Artamonova, J., Stanton, J.-A. L., Wescombe, P. A., Burton, J. P., Cullinan, M. P., & Tagg, J. R. (2011). Genome Sequence of the Bacteriocin-Producing Oral Probiotic Streptococcus salivarius Strain M18. Journal of Bacteriology, 193(22), 6402–6403. https://doi.org/10.1128/jb.06001-11
Özdemir, Ö. (2010). Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical data. Clinical & Experimental Immunology, 160(3), 295–304. https://doi.org/10.1111/j.1365-2249.2010.04109.x
Shyrobokov, V. P., Yankovsky, D. S., & Dyment, H. S. (2014). Mikrobiom liudyny ta suchasni metody yoho ozdorovlennia [Human microbiom and modern methods of its sanitation]. Infektsiini khvoroby, (2), 64 69. [in Ukrainian].
Macia, L., Thorburn, A. N., Binge, L. C., Marino, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J., & Mackay, C. R. (2012). Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunological Reviews, 245(1), 164–176. https://doi.org/10.1111/j.1600-065x.2011.01080.x
Grosdemange, A. (2014). Impact du microbiote intestinal sur le système immunitaire de l’enfant. [Doctoral thesis, Université de Lorraine]. Archive ouverte de l'Université de Lorraine. https://hal.univ-lorraine.fr/hal-01731902
Rigaux, P., Daniel, C., Hisbergues, M., Muraille, E., Hols, P., Pot, B., Pestel, J., & Jacquet, A. (2009). Immunomodulatory properties ofLactobacillus plantarumand its use as a recombinant vaccine against mite allergy. Allergy, 64(3), 406–414. https://doi.org/10.1111/j.1398-9995.2008.01825.x
Repa, A., Grangette, C., Daniel, C., Hochreiter, R., Hoffmann-Sommergruber, K., Thalhamer, J., Kraft, D., Breiteneder, H., Mercenier, A., & Wiedermann, U. (2003). Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy. Vaccine, 22(1), 87–95. https://doi.org/10.1016/s0264-410x(03)00528-0
Barletta, B., Rossi, G., Schiavi, E., Butteroni, C., Corinti, S., Boirivant, M., & Di Felice, G. (2013). Probiotic VSL#3-induced TGF-β ameliorates food allergy inflammation in a mouse model of peanut sensitization through the induction of regulatory T cells in the gut mucosa. Molecular Nutrition & Food Research, 57(12), 2233–2244. https://doi.org/10.1002/mnfr.201300028
Isolauri, E., Rautava, S., Kalliomäki, M., Kirjavainen, P., & Salminen, S. (2002). Role of probiotics in food hypersensitivity. Current Opinion in Allergy and Clinical Immunology, 2(3), 263–271. https://doi.org/10.1097/00130832-200206000-00018
Kim, J. Y., Choi, Y. O., & Ji, G. E. (2008). Effect of Oral Probiotics (Bifidobacterium lactis AD011 and Lactobacillus acidophilus AD031) Administration on Ovalbumin-Induced Food Allergy Mouse Model. Journal of Microbiology and Biotechnology, 18(8), 1393–1400.
Feleszko, W., Jaworska, J., Rha, R.-D., Steinhausen, S., Avagyan, A., Jaudszus, A., Ahrens, B., Groneberg, D. A., Wahn, U., & Hamelmann, E. (2007). Probiotic-induced suppression of allergic sensitization and airway inflammation is associated with an increase of T regulatory-dependent mechanisms in a murine model of asthma. Clinical & Experimental Allergy, 37(4), 498–505. https://doi.org/10.1111/j.1365-2222.2006.02629.x
Charalampopoulos, D., & Rastall, R. A. (2012). Prebiotics in foods. Current Opinion in Biotechnology, 23(2), 187–191. https://doi.org/10.1016/j.copbio.2011.12.028
Klewicka, E., Cukrowska, B., Libudzisz, Z., Slizewska, K., & Motyl, I. (2011). Changes in gut microbiota in children with atopic dermatitis administered the bacteria Lactobacillus casei DN–114001. Polish Journal of Microbiology, 60(4), 329–333.
Nedelska, S. M., Kuznietsova, O. D., Shevchenko, O. O., Kizilova, I. A., & Kolesnyk, O. Y. (2017). Efektyvnist probiotykiv u kompleksnii terapii atopichnoho dermatytu u ditei [Effectiveness of probiotics in combined therapy of atopic dermatitis]. Sovremennaya pediatriya, 4(84), 77 80. [in Ukrainian].
da Costa Baptista, I. P., Accioly, E., & de Carvalho Padilha, P. (2013). Effect of the use of probiotics in the treatment of children with atopic dermatitis; a literature review. Nutricion Hospitalaria, 28(1), 16 26. https://doi.org/10.3305/nh.2013.28.1.6207
Rosenfeldt, V., Benfeldt, E., Nielsen, S. D., Michaelsen, K. F., Jeppesen, D. L., Valerius, N. H., & Paerregaard, A. (2003). Effect of probiotic Lactobacillus strains in children with atopic dermatitis. Journal of Allergy and Clinical Immunology, 111(2), 389–395. https://doi.org/10.1067/mai.2003.389
Betsi, G. I., Papadavid, E., & Falagas, M. E. (2008). Probiotics for the Treatment or Prevention of Atopic Dermatitis. American Journal of Clinical Dermatology, 9(2), 93–103. https://doi.org/10.2165/00128071-200809020-00002
Gerasimov, S. V., Vasjuta, V. V., Myhovych, O. O., & Bondarchuk, L. I. (2010). Probiotic supplement reduces atopic dermatitis in preschool children: a randomized, double-blind, placebo-controlled, clinical trial. American Journal of Clinical Dermatology, 11(5), 351–361. https://doi.org/10.2165/11531420-000000000-00000
Han, Y., Kim, B., Ban, J., Lee, J., Kim, B. J., Choi, B. S., Hwang, S., Ahn, K., & Kim, J. (2012). A randomized trial ofLactobacillus plantarumCJLP133 for the treatment of atopic dermatitis. Pediatric Allergy and Immunology, 23(7), 667–673. https://doi.org/10.1111/pai.12010
Hattori, K., Yamamoto, A., Sasai, M., Taniuchi, S., Kojima, T., Kobayashi, Y., Iwamoto, H., Namba, K., & Yaeshima, T. (2003). Effects of administration of bifidobacteria on fecal microflora and clinical symptoms in infants with atopic dermatitis. Arerugi, 52(1), 20–30. [in Japanese].
Kalliomäki, M., Salminen, S., Poussa, T., Arvilommi, H., & Isolauri, E. (2003). Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. The Lancet, 361(9372), 1869–1871. https://doi.org/10.1016/s0140-6736(03)13490-3
Cabana, M. D. (2011). Early Probiotic Supplementation for the Prevention of Atopic Disease in Newborns. Bioscience and Microflora, 30(4), 129–133. https://doi.org/10.12938/bifidus.30.129
Rueter, K., Prescott, S. L., & Palmer, D. J. (2015). Nutritional approaches for the primary prevention of allergic disease: An update. Journal of Paediatrics and Child Health, 51(10), 962–969. https://doi.org/10.1111/jpc.12951
Smith-Norowitz, T. A., & Bluth, M. H. (2016). Probiotics and diseases of altered IgE regulation: A short review. Journal of Immunotoxicology, 13(2), 136–140. https://doi.org/10.3109/1547691x.2015.1044053
Taylor, A. L., Dunstan, J. A., & Prescott, S. L. (2007). Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial. Journal of Allergy and Clinical Immunology, 119(1), 184–191. https://doi.org/10.1016/j.jaci.2006.08.036
Muraro, A., Halken, S., Arshad, S. H., Beyer, K., Dubois, A. E. J., Du Toit, G., Eigenmann, P. A., Grimshaw, K. E. C., Hoest, A., Lack, G., O’Mahony, L., Papadopoulos, N. G., Panesar, S., Prescott, S., Roberts, G., de Silva, D., Venter, C., Verhasselt, V., Akdis, A. C., ... EAACI Food Allergy and Anaphylaxis Guidelines Group. (2014). EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy. Allergy, 69(5), 590–601. https://doi.org/10.1111/all.12398
Morelli, L., & Capurso, L. (2012). FAO/WHO Guidelines on Probiotics. Journal of Clinical Gastroenterology, 46, S1–S2. https://doi.org/10.1097/mcg.0b013e318269fdd5
Azad, M. B., Coneys, J. G., Kozyrskyj, A. L., Field, C. J., Ramsey, C. D., Becker, A. B., Friesen, C., Abou-Setta, A. M., & Zarychanski, R. (2013). Probiotic supplementation during pregnancy or infancy for the prevention of asthma and wheeze: systematic review and meta-analysis. BMJ, 347, Article f6471. https://doi.org/10.1136/bmj.f6471
Ismail, I. H., Licciardi, P. V., & Tang, M. L. (2013). Probiotic effects in allergic disease. Journal of Paediatrics and Child Health, 49(9), 709–715. https://doi.org/10.1111/jpc.12175
Nermes, M., Salminen, S., & Isolauri, E. (2013). Is There a Role for Probiotics in the Prevention or Treatment of Food Allergy? Current Allergy and Asthma Reports, 13(6), 622–630. https://doi.org/10.1007/s11882-013-0381-9
Tang, R.-B., Chang, J.-K., & Chen, H.-L. (2015). Can probiotics be used to treat allergic diseases? Journal of the Chinese Medical Association, 78(3), 154–157. https://doi.org/10.1016/j.jcma.2014.08.015
Sierra, C., Bernal, M.-J., Blasco, J., Martínez, R., Dalmau, J., Ortuño, I., Espín, B., Vasallo, M.-I., Gil, D., Vidal, M.-L., Infante, D., Leis, R., Maldonado, J., Moreno, J.-M., & Román, E. (2014). Prebiotic effect during the first year of life in healthy infants fed formula containing GOS as the only prebiotic: a multicentre, randomised, double-blind and placebo-controlled trial. European Journal of Nutrition, 54(1), 89–99. https://doi.org/10.1007/s00394-014-0689-9
Fiocchi, A., Pawankar, R., Cuello-Garcia, C., Ahn, K., Al-Hammadi, S., Agarwal, A., Beyer, K., Burks, W., Canonica, G. W., Ebisawa, M., Gandhi, S., Kamenwa, R., Lee, B. W., Li, H., Prescott, S., Riva, J. J., Rosenwasser, L., Sampson, H., Spigler, M., … Schünemann, H. J. (2015). World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics. World Allergy Organization Journal, 8(1), 4. https://doi.org/10.1186/s40413-015-0055-2
Szachta, P., & Gałęcka, M. (2016). Od jelita do alergii. In M. Jarosz (Ed.), Alergie pokarmowe (pp. 132 140). Pzwl. https://docplayer.pl/25520075-Od-jelita-do-alergii-czyli-znaczenie-bariery-jelitowej-w-chorobach-alergicznych.html. [in Polish].
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