Genetic determinants of lipid aberrations in patents with essential hypertension

Authors

  • V. V. Buriak Zaporizhzhia State Medical University, Ukraine,
  • V. A. Vizir Zaporizhzhia State Medical University, Ukraine,
  • O. V. Demidenko Zaporizhzhia State Medical University, Ukraine,

DOI:

https://doi.org/10.14739/2310-1210.2020.2.200564

Keywords:

apolipoprotein E, genetic polymorphism, essential hypertension, dyslipidemia

Abstract

 

Aim. To reveal the relationship between apolipoprotein E gene polymorphism and lipid spectrum modification in patients with essential hypertension.

Materials and methods. The lipid spectrum components and apolipoprotein E gene polymorphism were analyzed in 310 patients with essential hypertension.

Results. The mean plasma levels of total cholesterol, high and low density lipoproteins, triglycerides and the atherogenic index were 5.18 ± 0.08 mmol/l, 1.32 ± 0.03 mmol/l, 3.06 ± 0.07 mmol/l, 1.74 ± 0.05 mmol/l and 3.21 ± 0.08, respectively. In patients with essential hypertension, the genetic polymorphism of apolipoprotein E was characterized by the alleles E2 (13.26 %), E3 (93.87 %) and E4 (30.65 %) presence. Based on single nucleotide polymorphism identification, there were defined the following genotypes: E2/E2 (0.65 %), E2/E3 (10.97 %), E2/E4 (1.61 %), E3/E3 (57.74 %), E3/E4 (25.16 %) and E4/E4 (3.87 %). Individuals with E2/E4 genotype had higher levels of total cholesterol (+17.56 %, P < 0.05) and low density lipoproteins (+25.7 %, P < 0.01), and atherogenic index was increased (+38.18 %, P < 0.05) in E4/E4 carriers in comparison with E2/E3. Hypertonic E4/E4 carriers were found to have elevated plasma triglycerides (+20.23 %, P < 0.05) in comparison with E3/E3, as well as increased triglycerides (+25.3 %, p < 0.05) and very low density lipoproteins (+25.33 %, P < 0.05) in comparison with E3/E4 carriers. E3/E3 and E3/E4 carriers demonstrated decrease in total cholesterol (-12.9 %, P < 0.05) and (-11.04 %, P < 0.05), respectively, as well as low density lipoproteins (-15.69 %, P < 0.001) and (-11.48 %, P < 0.05), respectively, as compared to E2/E4. The plasma content of high density lipoproteins was not dependent on ApoE genotype.

Conclusions. In patients with essential hypertension, the most common allele is E3 (93.87 %) and the E3/E3 genotype (57.74 %), while the E3/E4 genotype is 25.16 %. Presence of the E2/E4 genotype is significantly associated with the elevated total cholesterol and low density lipoproteins plasma levels, whereas the E4/E4 genotype is accompanied by the increased triglycerides, low density lipoproteins levels and atherogenic index.

 

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1.
Buriak VV, Vizir VA, Demidenko OV. Genetic determinants of lipid aberrations in patents with essential hypertension. Zaporozhye Medical Journal [Internet]. 2020Apr.13 [cited 2024Nov.22];22(2). Available from: http://zmj.zsmu.edu.ua/article/view/200564

Issue

Vol. 22 No. 2 (2020)

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Original research

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