Pregnancy and breast cancer: optimal patient management tactics (a literature review)


  • O. P. Kolesnik Zaporizhzhia State Medical University, Oncolife LLC, Ukraine, Ukraine
  • A. I. Shevchenko Zaporizhzhia State Medical University, Ukraine, Ukraine
  • A. V. Kadzhoian Zaporizhzhia State Medical University; Oncolife LLC, Ukraine, Ukraine
  • O. M. Levyk Zaporizhzhia State Medical University, Oncolife LLC, Ukraine, Ukraine
  • D. Ye. Chernyavskyi Zaporizhzhia State Medical University, Oncolife LLC, Ukraine, Ukraine
  • V. O. Kuzmenko Zaporizhzhia State Medical University, Oncolife LLC, Ukraine, Ukraine
  • L. S. Lytvynenko Zaporizhzhia State Medical University, Ukraine, Ukraine



breast cancer, pregnancy, cancer, chemotherapy, radiation


Breast cancer is one of the most widespread malignant neoplasm in Ukraine (20.6 % of all malignant neoplasms). The usual incidence of breast cancer (BC) in women, as of 2019, is 70.3 cases per 100 thousand population. At the moment, BC during pregnancy is rare (only in 0.4 % of all BC cases in women aged 16 to 49 years), the decision on treatment remains difficult for a patient as well as an oncologists.

Despite the fact that the treatment of malignant breast disease is usually carried out in non-pregnant women, the problem of tactics for managing patients with different gestation lengths remains unresolved. Thus, the treatment of pregnant women with BC should be guided a multidisciplinary integrated approach to maximize the benefits and minimize the risk to both a mother and a fetus, including the optimal tactics of surgical treatment and chemotherapy. Therapeutic decisions should be based on the stage of disease, tumor morphology, gestational age at diagnosis, and possible pregnancy risks.

A promising way of addressing this problem is to conduct more studies to determine the most effective and safest treatment strategies for BC in pregnant women.

Author Biographies

O. P. Kolesnik, Zaporizhzhia State Medical University, Oncolife LLC, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Oncology and Oncosurgery, oncologist, oncosurgeon

A. I. Shevchenko, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Professor f the Department of Oncology and Oncosurgery

A. V. Kadzhoian, Zaporizhzhia State Medical University; Oncolife LLC, Ukraine

MD, PhD, Assistant of the Department of Oncology and Oncosurgery, Director of Oncolife LLC

O. M. Levyk, Zaporizhzhia State Medical University, Oncolife LLC, Ukraine

MD, PhD, Associate Professor of the Department of Oncology and Oncosurgery, oncologist

D. Ye. Chernyavskyi, Zaporizhzhia State Medical University, Oncolife LLC, Ukraine

MD, Senior Laboratory Assistant, oncologist

V. O. Kuzmenko, Zaporizhzhia State Medical University, Oncolife LLC, Ukraine

MD, Assistant of the Department of Oncology and Oncosurgery,  oncologist, oncosurgeon

L. S. Lytvynenko, Zaporizhzhia State Medical University, Ukraine

sixth-year student of the 1st Medical Faculty


Alfasi, A., & Ben-Aharon, I. (2019). Breast Cancer during Pregnancy-Current Paradigms, Paths to Explore. Cancers, 11(11), Article 1669.

Bae, S. Y., Kim, K. S., Kim, J. S., Lee, S. B., Park, B. W., Lee, S. W., Lee, H. J., Kim, H. K., You, J. Y., Jung, S. P., & Korean Breast Cancer Society. (2018). Neoadjuvant Chemotherapy and Prognosis of Pregnancy-Associated Breast Cancer: A Time-Trends Study of the Korean Breast Cancer Registry Database. Journal of Breast Cancer, 21(4), 425-432.

Balaya, V., Bonsang-Kitzis, H., Ngo, C., Delomenie, M., Gosset, M., Mimouni, M., Nos, C., David, P. M., Bats, A. S., & Lecuru, F. (2018). What about sentinel lymph node biopsy for early breast cancer during pregnancy? Journal of Gynecology Obstetrics and Human Reproduction, 47(5), 205-207.

Botha, M. H., Rajaram, S., & Karunaratne, K. (2018). Cancer in pregnancy. International Journal of Gynaecology and Obstetrics, 143(Suppl. 2), 137-142.

Durrani, S., Akbar, S., & Heena, H. (2018). Breast Cancer During Pregnancy. Cureus, 10(7), Article e2941.

Feng, C., Yu, D., & Qian, J. (2019). Long-Term Results and Predictors of Survival After Conservative Breast Surgery for Breast Cancer During Pregnancy. Medical Science Monitor, 25, 8587-8594.

Goidescu, I., Nemeti, G., Caracostea, G., Eniu, D. T., Chiorean, A., Pintican, R., Cruciat, G., & Muresan, D. (2019). The role of imaging techniques in the diagnosis, staging and choice of therapeutic conduct in pregnancy associated breast cancer. Medical Ultrasonography, 21(3), 336-343.

Gomez-Hidalgo, N. R., Mendizabal, E., Joigneau, L., Pintado, P., & De Leon-Luis, J. (2019). Breast cancer during pregnancy: results of maternal and perinatal outcomes in a single institution and systematic review of the literature. Journal of Obstetrics and Gynaecology, 39(1), 27-35.

Gooch, J. C., Chun, J., Kaplowitz, E., Guth, A., Axelrod, D., Shapiro, R., Roses, D., & Schnabel, F. (2020). Pregnancy-associated breast cancer in a contemporary cohort of newly diagnosed women. The Breast Journal, 26(4), 668-671.

Hazama, Y., Nakai, Y., Sugawara, S., Nomura, T., Matsumoto, K., Matsumoto, R., Sugihara, M., Ishida, T., Murata, S., Murata, T., Nakamura, T., Moriya, T., Kurebayashi, J., & Shimoya, K. (2018). A Case Report of Surgery and Chemotherapy for a Patient with Rapidly Progressing Breast Cancer during Pregnancy. Gan to kagaku ryoho. Cancer & chemotherapy, 45(5), 847-850.

Johansson, A., Andersson, T. M., Hsieh, C. C., Jirström, K., Cnattingius, S., Fredriksson, I., Dickman, P. W., & Lambe, M. (2018). Tumor characteristics and prognosis in women with pregnancy-associated breast cancer. International Journal of Cancer, 142(7), 1343-1354.

Knabben, L., & Mueller, M. D. (2017). Breast cancer and pregnancy. Hormone Molecular Biology and Clinical Investigation, 32(1).

Lee, G. E., Rosenberg, S. M., Mayer, E. L., Borges, V., Meyer, M. E., Schapira, L., Come, S. E., & Partridge, A. H. (2019). Contemporary management of breast cancer during pregnancy and subsequent lactation in a multicenter cohort of young women with breast cancer. The Breast Journal, 25(6), 1104-1110.

Lund, P. S., Saltvig, I., Oldenburg, M. H., & Matzen, S. H. (2018). Diagnostics, treatment and prognosis in breast cancer during pregnancy. Ugeskrift for laeger, 180(27), Article V09170665.

Macdonald, H. R. (2020). Pregnancy associated breast cancer. The Breast Journal, 26(1), 81-85.

Martínez, M. T., Bermejo, B., Hernando, C., Gambardella, V., Cejalvo, J. M., & Lluch, A. (2018). Breast cancer in pregnant patients: A review of the literature. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 230, 222-227.

Maxwell, C. V., Al-Sehli, H., Parrish, J., & D'Souza, R. (2019). Breast Cancer in Pregnancy: A Retrospective Cohort Study. Gynecologic and Obstetric Investigation, 84(1), 79-85.

Paris, I., Di Giorgio, D., Carbognin, L., Corrado, G., Garganese, G., Franceschini, G., Sanchez, A. M., De Vincenzo, R. P., Accetta, C., Terribile, D. A., Magno, S., Di Leone, A., Bove, S., Masetti, R., & Scambia, G. (2021). Pregnancy-Associated Breast Cancer: A Multidisciplinary Approach. Clinical Breast Cancer, 21(1), e120-e127.

Peccatori, F. A., Lambertini, M., Scarfone, G., Del Pup, L., & Codacci-Pisanelli, G. (2018). Biology, staging, and treatment of breast cancer during pregnancy: reassessing the evidences. Cancer Biology & Medicine, 15(1), 6-13.

Polivka, J., Jr., Altun, I., & Golubnitschaja, O. (2018). Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine. EPMA Journal, 9(1), 1-13.

Ramesh, P., Srikumar, S., Mahendran, V., Nair, S. S., & Radhamany, K. (2019). Pregnancy-Associated Breast Cancer: A Realistic Approach. The Journal of Obstetrics and Gynecology of India, 69(6), 514-519.

Rojas, K. E., Bilbro, N., Manasseh, D. M., & Borgen, P. I. (2019). A Review of Pregnancy-Associated Breast Cancer: Diagnosis, Local and Systemic Treatment, and Prognosis. Journal of Women's Health, 28(6), 778-784.

Shah, N. M., Scott, D. M., Kandagatla, P., Moravek, M. B., Cobain, E. F., Burness, M. L., & Jeruss, J. S. (2019). Young Women with Breast Cancer: Fertility Preservation Options and Management of Pregnancy-Associated Breast Cancer. Annals of Surgical Oncology, 26(5), 1214-1224.

Simoes, E., Graf, J., Sokolov, A. N., Grischke, E. M., Hartkopf, A. D., Hahn, M., Weiss, M., Abele, H., Seeger, H., & Brucker, S. Y. (2018). Pregnancy-associated breast cancer: maternal breast cancer survival over 10 years and obstetrical outcome at a university centre of women's health. Archives of Gynecology and Obstetrics, 298(2), 363-372.

Slepicka, P. F., Cyrill, S. L., & Dos Santos, C. O. (2019). Pregnancy and Breast Cancer: Pathways to Understand Risk and Prevention. Trends in Molecular Medicine, 25(10), 866-881.

Subramani, R., & Lakshmanaswamy, R. (2017). Pregnancy and Breast Cancer. Progress in Molecular Biology and Translational Science, 151, 81-111.

Suleman, K., Osmani, A. H., Al Hashem, H., Al Twegieri, T., Ajarim, D., Jastaniyah, N., Al Khayal, W., Al Malik, O., & Al Sayed, A. (2019). Behavior and Outcomes of Pregnancy Associated Breast Cancer. Asian Pacific Journal of Cancer Prevention, 20(1), 135-138.

Taşkın, F., Polat, Y., Erdoğdu, İ. H., & Soyder, A. (2019). Pregnancy-associated breast cancer: A review of 47 women. Clinical Imaging, 58, 182-186.

van Hasselt, J., van Calsteren, K., Heyns, L., Han, S., Mhallem Gziri, M., Schellens, J., Beijnen, J. H., Huitema, A., & Amant, F. (2014). Optimizing anticancer drug treatment in pregnant cancer patients: pharmacokinetic analysis of gestation-induced changes for doxorubicin, epirubicin, docetaxel and paclitaxel. Annals of Oncology, 25(10), 2059-2065.

Wang, B., Yang, Y., Jiang, Z., Zhao, J., Mao, Y., Liu, J., & Zhang, J. (2019). Clinicopathological characteristics, diagnosis, and prognosis of pregnancy-associated breast cancer. Thoracic Cancer, 10(5), 1060-1068.



How to Cite

Kolesnik, O. P., Shevchenko, A. I. ., Kadzhoian, A. V. ., Levyk, O. M. ., Chernyavskyi, D. Y. ., Kuzmenko, V. O. ., & Lytvynenko, L. S. (2021). Pregnancy and breast cancer: optimal patient management tactics (a literature review). Zaporozhye Medical Journal, 23(4), 599–604.