DOI: https://doi.org/10.14739/2310-1210.2020.5.214737

Оценка состояния нервной системы детей с низкой массой тела при рождении, учитывая полиморфизм С/Т гена FADS2 (RS174583)

T. Yе. Shumna, T. O. Levchuk-Vorontsova

Аннотация


 

Цель работы – оценить неврологическое состояние и индекс нервно-психического развития детей, родившихся с низкой массой тела, учитывая полиморфизм С/Т гена FADS2 (RS174583).

Материалы и методы. Для изучения полиморфизма С/Т гена FADS2 (rs174583) обследовали 170 детей. Детей поделили на 3 группы в зависимости от веса при рождении: I группа – 53 ребенка с весом при рождении 1500–1999 г, сроком гестации 33,0 [32,0; 35,0] недели; II группа – 77 детей с весом при рождении 2000–2499 г, сроком гестации 35,0 [34,0; 36,0] недели; III группа (контроля) – 40 детей с весом при рождении больше 2500 г и сроком гестации 38,0 [36,0; 39,0] недели. Генотипирование провели методом полимеразной цепной реакции.

Результаты. Частота обнаружения аллеля С полиморфизма С/Т гена FADS2 (rs174583) приближалась к показателям северо-западной Европы. Поражение нервной системы в виде судорог чаще всего регистрировали у детей с генотипом ТТ (16,45 %, р < 0,05), а у пациентов с генотипом СС судороги отмечены только в 5,6 % случаев. Дети с весом при рождении 1500–1999 г (и гетерозиготы, и гомозиготы по аллелю Т) имели достоверно более низкую оценку по шкале Апгар, чем дети с весом более 2000 г (p < 0,05). Индекс психомоторного развития самый низкий у детей с массой тела при рождении 1500–1999 г с минорным гомозиготным генотипом гена FADS2 (rs1745683), составляя 83,0 (75,0; 83,0); самый высокий показатель индекса психомоторного развития (116,0 (112,0; 141,0)) достоверно чаще регистрировали у детей с генотипом СС и массой тела при рождении более 2500 г.

Выводы. Вероятно, преобладание доминантного генотипа СС и гетерозиготного генотипа СТ имеет протекторную функцию для защиты нервной системы от негативного влияния, связанного с преждевременным рождением.

 


Ключевые слова


аллельные гены; генотипы; полиненасыщенные жирные кислоты; преждевременные роды; дети

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Литература


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