DOI: https://doi.org/10.14739/2310-1210.2020.5.214751

Особенности применения лекарств off-label в педиатрии

S. M. Drohovoz, Ya. O. Butko, L. B. Іvantsyk, C. H. Shchokina, H. V. Bielik, V. D. Lukianchuk

Аннотация


 

Назначение препаратов – непростая задача для педиатров, так как ассортимент выбора лекарств в педиатрии на 2/3 меньше, чем у взрослых больных.

Цель работы – проанализировать данные научной литературы об опыте применения лекарств off-label в мировой педиатрии.

Материалы и методы. Библиосемантический анализ, обзор литературы, статистический анализ.

Результаты. На основе проведенного анализа установлено, что одна из наиболее важных причин назначения лекарств off-label «вне инструкции» детям – отсутствие стандартных, лицензированных и безопасных терапевтических вариантов клинических испытаний лекарств при некоторых заболеваниях или состояниях у детей. Приведены возможные подходы к решению проблем «off-lable use» лекарств в медицине и здравоохранении.

Выводы. Ситуацию использования лекарств off-label у детей можно улучшить благодаря сообщениям врачей о педиатрическом опыте с различными лекарствами off-label в виде научных статей, обсуждений на научных конференциях, с высокой степенью доказательности. Принимая решение о назначении лекарств off-label ребенку, врачи должны быть уверены, что это единственный правильный шаг при условии наличия национального формуляра и национального перечня основных лекарственных средств.

 


Ключевые слова


педиатрия; фармакотерапия; off-label use

Полный текст:

PDF (English)

Литература


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