Analysis of physical therapy application in children with acute lymphoblastic leukemia (literature review)

Authors

DOI:

https://doi.org/10.14739/2310-1210.2021.3.215664

Keywords:

physical therapy, acute lymphoblastic leukemia, fatigue, physical activity, children

Abstract

The aim – theoretical review of the use of physical therapy in children with acute lymphoblastic leukemia.

The problem of restoring the health of children with acute lymphoblastic leukemia (GLL) is due to the increased incidence of cancer, the duration of special treatment and the development of complications and comorbidities.

The main complaints are fatigue, pain, muscle weakness, decreased mobility and endurance, depression, anxiety, mood swings. Pathology of the musculoskeletal system, gastrointestinal tract and endocrine system occur with equal frequency.

Today, the main expected therapeutic effect in pediatric oncology should be considered not only the clinical recovery of patients, but also their return to the previous social position in the family, school and community, the restoration of physical, psychological and social health. The problem of physical therapy of children with acute lymphoblastic leukemia was studied by many scientists. According to the literature, physical exercises reduce the fatigue associated with the tumor process, improving the functional capacity of the body and increasing metabolism. There is a positive effect of exercise on muscle strength and flexibility, but there are ambiguous conclusions from different authors on the effect of exercise on cardio-respiratory function in the course of maintenance therapy in children with GLL who have cancer fatigue.

Conclusions. An important area of physical therapy in oncology is the use of dosed physical activity, which, according to many researchers, increases the effectiveness of treatment. Recently, the prevailing opinion is that regular physical activity is safe and can have potential benefits for the musculoskeletal, cardiovascular, respiratory and immune systems of pediatric patients with hematological diseases.

Author Biographies

O. A. Bas, Lviv State University of Physical Culture named after Ivan Boberskyj, Ukraine

PhD, Associate Professor of the Department of Physical Therapy and Occupational Therapy

N. O. Ivasyk, Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Lviv, Ukraine

PhD, Associate Professor of the Department of Rehabilitation and Human Health

O. I. Tyravska, Lviv State University of Physical Culture named after Ivan Boberskyj, Ukraine

PhD, Associate Professor of the Department of Physical Therapy and Occupational Therapy

A. M. Hertsyk, Ukrainian Catholic University, Lviv, Ukraine

PhD, DSc, Professor of the Department of Physical Therapy and Occupational Therapy

References

Yeh, C. H., Man Wai, J. P., Lin, U. S., & Chiang, Y. C. (2011). A Pilot Study to Examine the Feasibility and Effects of a Home-Based Aerobic Program on Reducing Fatigue in Children With Acute Lymphoblastic Leukemia. Cancer Nursing, 34(1), 3-12. https://doi.org/10.1097/NCC.0b013e3181e4553c

Knips, L., Bergenthal, N., Streckmann, F., Monsef, I., Elter, T., & Skoetz, N. (2019). Aerobic physical exercise for adult patients with haematological malignancies. Cochrane Database of Systematic Reviews, 1(1), Article CD009075. https://doi.org/10.1002/14651858.CD009075.pub3

Alias, H., Mohd Nazi, N. A., & Lau Sie Chong, D. (2019). Participation in Physical Activity and Physical Education in School Among Children With Acute Lymphoblastic Leukemia After Intensive Chemotherapy. Frontiers in Pediatrics, 7, Article 73. https://doi.org/10.3389/fped.2019.00073

Baumann, F. T., Bloch, W., & Beulertz, J. (2013). Clinical exercise interventions in pediatric oncology: a systematic review. Pediatric Research, 74(4), 366-374. https://doi.org/10.1038/pr.2013.123

Cortés-Reyes, É., Escobar-Zabala, P., & González-García, L. (2013). The effect of game-based exercise on infant acute lymphocytic leukaemia patients. Revista de la Facultad de Medicina, 61(4), 349-355. https://pesquisa.bvsalud.org/portal/resource/pt/lil-703375

Hoffman, M. C., Mulrooney, D. A., Steinberger, J., Lee, J., Baker, K. S., & Ness, K. K. (2013). Deficits in Physical Function Among Young Childhood Cancer Survivors. Journal of Clinical Oncology, 31(22), 2799-2805. https://doi.org/10.1200/JCO.2012.47.8081

Zhou, Y., Zhu, J., Gu, Z., & Yin, X. (2016). Efficacy of Exercise Interventions in Patients with Acute Leukemia: A Meta-Analysis. PLOS ONE, 11(7), Article e0159966. https://doi.org/10.1371/journal.pone.0159966

Wolin, K. Y., Ruiz, J. R., Tuchman, H., & Lucia, A. (2010). Exercise in adult and pediatric hematological cancer survivors: an intervention review. Leukemia, 24(6), 1113-1120. https://doi.org/10.1038/leu.2010.54

Esbenshade, A. J., Friedman, D. L., Smith, W. A., Jeha, S., Pui, C. H., Robison, L. L., & Ness, K. K. (2014). Feasibility and Initial Effectiveness of Home Exercise During Maintenance Therapy for Childhood Acute Lymphoblastic Leukemia. Pediatric Physical Therapy, 26(3), 301-307. https://doi.org/10.1097/PEP.0000000000000053

Gohar, S. F., Comito, M., Price, J., & Marchese, V. (2011). Feasibility and parent satisfaction of a physical therapy intervention program for children with acute lymphoblastic leukemia in the first 6 months of medical treatment. Pediatric Blood & Cancer, 56(5), 799-804. https://doi.org/10.1002/pbc.22713

Sylvan, S. E., Asklid, A., Johansson, H., Klintman, J., Bjellvi, J., Tolvgård, S., Kimby, E., Norin, S., Andersson, P. O., Karlsson, C., Karlsson, K., Lauri, B., Mattsson, M., Sandstedt, A. B., Strandberg, M., Österborg, A., & Hansson, L. (2019). First-line therapy in chronic lymphocytic leukemia: a Swedish nation-wide real-world study on 1053 consecutive patients treated between 2007 and 2013. Haematologica, 104(4), 797-804. https://doi.org/10.3324/haematol.2018.200204

De Luca, C. R., McCarthy, M., Galvin, J., Green, J. L., Murphy, A., Knight, S., & Williams, J. (2013). Gross and fine motor skills in children treated for acute lymphoblastic leukaemia. Developmental Neurorehabilitation, 16(3), 180-187. https://doi.org/10.3109/17518423.2013.771221

Hudson, M. M., Mulrooney, D. A., Bowers, D. C., Sklar, C. A., Green, D. M., Donaldson, S. S., Oeffinger, K. C., Neglia, J. P., Meadows, A. T., & Robison, L. L. (2009). High-Risk Populations Identified in Childhood Cancer Survivor Study Investigations: Implications for Risk-Based Surveillance. Journal of Clinical Oncology, 27(14), 2405-2414. https://doi.org/10.1200/JCO.2008.21.1516

Huang, T. T., & Ness, K. K. (2011). Exercise Interventions in Children with Cancer: A Review. International journal of pediatrics, 2011, Article 461512. https://doi.org/10.1155/2011/461512

Kurpiers, N., Vogler, T., & Flohr, S. (2018). Effects of an Intense One-Week Skiing Program on Balance Abilities in Pediatric Cancer Patients. International Journal of Sports and Exercise Medicine, 4(4), Article 105. https://doi.org/10.23937/2469-5718/1510105

Wright, M. J., Halton, J. M., Martin, R. F., & Barr, R. D. (1998). Long-term gross motor performance following treatment for acute lymphoblastic leukemia. Medical and Pediatric Oncology, 31(2), 86-90. https://doi.org/10.1002/(sici)1096-911x(199808)31:2<86::aid-mpo7>3.0.co;2-v

Courneya, K. S., Sellar, C. M., Stevinson, C., McNeely, M. L., Friedenreich, C. M., Peddle, C. J., Basi, S., Chua, N., Tankel, K., Mazurek, A., & Reiman, T. (2009). Moderator Effects in a Randomized Controlled Trial of Exercise Training in Lymphoma Patients. Cancer Epidemiology, Biomarkers & Prevention, 18(10), 2600-2607. https://doi.org/10.1158/1055-9965.EPI-09-0504

Morishita, S., & Tsubaki, A. (2017). Physical Therapy in Patients with Cancer. Clinical Physical Therapy. IntechOpen. https://doi.org/10.5772/67286

Green, J. L., Knight, S. J., McCarthy, M., & De Luca, C. R. (2013). Motor functioning during and following treatment with chemotherapy for pediatric acute lymphoblastic leukemia. Pediatric Blood & Cancer, 60(8), 1261-1266. https://doi.org/10.1002/pbc.24537

Hamari, L., Lähteenmäki, P. M., Pukkila, H., Arola, M., Axelin, A., Salanterä, S., & Järvelä, L. S. (2020). Motor Performance in Children Diagnosed with Cancer: A Longitudinal Observational Study. Children, 7(8), Article 98. https://doi.org/10.3390/children7080098

Patti, A., Paoli, A., Bianco, A., & Palma, A. (2013). Pediatric exercise programs in children with hematological cancer: a systematic review. Università degli Studi di Palermo. http://hdl.handle.net/10447/99216

Peterson, J., & Darling, T. (2018). Childhood Cancer and Treatment Effects on Motor Performance. International Journal of Exercise Science, 11(3), 657-668.

Braam, K. I., van der Torre, P., Takken, T., Veening, M. A., van Dulmen-den Broeder, E., & Kaspers, G. J. (2016). Physical exercise training interventions for children and young adults during and after treatment for childhood cancer. Cochrane database of systematic reviews, 3(3), Article CD008796. https://doi.org/10.1002/14651858.CD008796.pub3

Simioni, C., Zauli, G., Martelli, A. M., Vitale, M., Ultimo, S., Milani, D., & Neri, L. M. (2018). Physical training interventions for children and teenagers affected by acute lymphoblastic leukemia and related treatment impairments. Oncotarget, 9(24), 17199-17209. https://doi.org/10.18632/oncotarget.24762

Lanfranconi, F., Zardo, W., Moriggi, T., Villa, E., Radaelli, G., Radaelli, S., Paoletti, F., Bottes, E., Miraglia, T., Pollastri, L., Vago, P., Nichelli, F., Jankovic, M., Biondi, A., & Balduzzi, A. (2020). Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies. Scientific Reports, 10(1), Article 12892. https://doi.org/10.1038/s41598-020-69393-1

Muratt, M. D., Perondi, M. B., Greve, J. M., Roschel, H., Pinto, A. L., & Gualano, B. (2011). Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study. Clinics, 66(7), 1277-1281. https://doi.org/10.1590/s1807-59322011000700026

Hayes, S., Davies, P. S., Parker, T., & Bashford, J. (2003). Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme. Bone Marrow Transplantation, 31(5), 331-338. https://doi.org/10.1038/sj.bmt.1703867

Skvortsova, Yu. V., Maschan, A. A., Delyagin, V. M., Sidorenko, L. V., Tseitlin, G. Ya., Volodin, N. N., Rumyantsev, A. G. (2014). Aktual'nye voprosy nablyudeniya, diagnostiki i reabilitatsii patsientov na otdalennykh srokakh posle transplantatsii gemopoeticheskikh stvolovykh kletok [The follow-up, diagnosis, and rehabilitation of patients in late periods following hematopoietic stem cell transplantation: Topical issues]. Rossiiskii zhurnal detskoi gematologii i onkologii, 1(2), 13-18. [in Russian].

Vseukrainska hromadska orhanizatsiia “Asotsiatsiia dopomohy invalidam ta patsiientam z KhLPZ”. (2012, March 05). Fizychna reabilitatsiia khvorykh na limfoproliferatyvni zakhvoriuvannia [Physical rehabilitation of patients with lymphoproliferative disorders]. http://lympho.com.ua/2012/03/05/fizichna-reabilitatsiya-hvorih-na-limfoproliferativni-zahvoryuvannya/ [in Ukrainian].

Tikhonova, O. A., Krutikova, N. Yu., Karelin, A. F., Zhukovskaya, E. V., & Rumyantsev, A. G. Vliyanie zlokachestvennykh novoobrazovanii na costoyanie kostno-myshechnoi sistemy u detei (obzor literatury) [Impact of malignant neoplasms on musculoskeletal system in children (literature review)]. Onkogematologiya, 13(4), 60-66. https://doi.org/10.17650/1818-8346-2019-13-4-60-66 [in Russian].

Grushina, T. I. (2018). Fizioterapiya pri meditsinskoi reabilitatsii detei so zlokachestvennymi novoobrazovaniyami [Physiotherapy in the Medical Rehabilitation of Children with Malignant Tumors]. Onkopediatriya, 5(3), 164-174. https://doi.org/10.15690/onco.v5i3.1934 [in Russian].

Zagoskina, O. A., Nurgaleeva, A. A., & Shtrakhova, A. V. (2017). Psikhologicheskaya reabilitatsiya semei s det'mi, perenesshimi onkogematologicheskie zabolevaniya [Psychological Rehabilitation of Families with Children Who Have Suffered Oncogematological Diseases]. Vestnik YuUrGU. Seriya «Psikhologiya», 10(1), 88-98. https://doi.org/10.14529/psy170109 [in Russian].

Kaladze, N. N., Karmazina, I. V., & Meltseva, E. M. (2016). Reabilitatsiya immunnoi sistemy u detei, prolechennykh po povodu onkopatologii, na etape sanatorno-kurortnogo lecheniya [Rehabilitation of the immune system in children treated for cancer pathology, at the stage of spa treatment]. Vestnik fizioterapii i kurortologii, 22(3), 4-12. [in Russian].

Ledneva, N., Kondratchik, K., Rudneva, E., Kozlovskaya, M., Guseva, M., Safiullina, A., Shvemmer, E., Aver'yanova, L., Altunyan, Zh., Byalik, M., Papushina, E., & Vasil'eva, O. Kniga v pomoshch': posobie po lecheniyu detskogo leikoza i drugikh onkologicheskikh zabolevanii v pomoshch' mamam i papam, babushkam i dedushkam, druz'yam, rodstvennikam i drugim dobrym lyudyam [Helping book: a handbook for treatment of childhood leukemia and other oncological diseases to help mothers and fathers, grandparents, friends, relatives and other good people] (2nd ed.). Moscow. [in Russian].

Lagunova, N. V. (2005). Patohenetychne obhruntuvannia sanatorno-kurortnoi reabilitatsii ditei z onko-hematolohichnymy zakhvoriuvanniamy. (Avtoref. dis. … dokt. med. nauk). [Pathogenetic substantiation of sanatorium-resort rehabilitation in children with hemato-oncological diseases]. (Extended abstract of doctoral thesis). Simferopol. [in Ukrainian].

Mel'tseva, E. M., Kaladze, N. N., & Karmazina, I. V. (2015). Reabilitatsiya onkologicheskikh bol'nykh i vozmozhnosti sanatorno-kurortnogo etapa [Rehabilitation in oncological patients and sanatorium-resort stage potential]. Vestnik fizioterapii i kurortologii, 21(2), 143. [in Russian].

Mentkevich, G. L., & Mayakova, S. A. (Eds.). (2009). Leikozy u detei [Leukemia in children]. Prakticheskaya meditsina. [in Russian].

Misiak, S. A., Lomako, L. V., & Rogozha, S. A. (2016). Vliyanie reabilitatsionnykh meropriyatii na uroven' agressivnosti i trevozhnosti u detei s onkologicheskimi zabolevaniyami [Effect of rehabilitation on the level of aggression and anxiety in children with cancer]. Klinicheskaya onkologiya, (2), 40-42. [in Russian].

Mitrakov, N. N., Korochkin, A. V., & Laysheva, O. A. (2016). Reabilitatsiya detei i podrostkov, poluchayushchikh vysokodoznuyu khimioterapiyu s posleduyushchei transplantatsiei gemopoeticheskikh stvolovykh kletok [Rehabilitation of children and adolescents receiving high-dose chemotherapy with subsequent haemopoietic stem cell transplantation]. Voprosy gematologii/onkologii i immunopatologii v pediatrii, 15(4), 103-109. https://doi.org/10.24287/1726-1708-2016-15-4-103-109 [in Russian].

Tseitlin, G. Ya., Sidorenko, L. V., Volodin, N. N., & Rumyantsev, N. N. (2014). Organizatsiya meditsinskoi i psikhologo-sotsial'noi reabilitatsii detei i podrostkov s onkologicheskimi i gematologicheskimi zabolevaniyami [Organization of medical and psychosocial rehabilitation in children and adolescents with cancer and blood diseases]. Rossiiskii zhurnal detskoi gematologii i onkologii, 1(3), 59-65. [in Russian].

Zhukovskaya, E. V., Litvinenko, M. V., Karelin, A. F., Kasatkin, V. N., Mironova, E. V., Pankratieva, L. L., Muftakhova, G. M., Shamanskaya, Т. V., & Rumyantsev, A. G. (2017). Reabilitatsiya/abilitatsiya detei grudnogo i mladshego vozrasta v usloviyakh spetsializirovannogo meditsinskogo tsentra dlya patsientov s zabolevaniyami krovi i zlokachestvennymi novoobrazovaniyami [Rehabilitation/habilitation of infants and young children in a specialized medical center for patients with blood diseases and malignant neoplasms]. Rossiiskii zhurnal detskoi gematologii i onkologii, 4(3), 81-84. https://doi.org/10.17650/2311-1267-2017-4-3-81-84 [in Russian].

Tkachenko, I. V., Teslenko, B. V., & Rumyantsev, A. G. (2009). Kompleksnaya reabilitatsiya detei s ostrym limfoblastnym leikozom v sostoyanii dlitel'noi remissii [Complex rehabilitation of children with long-term acute lymphoblastic leukemia remission]. Onkogematologiya, 4(2), 42-51. [in Russian].

Shapovalova, A. A., & Polschakova, T. V. (2018). Obhruntuvannia sposobu sanatorno-kurortnoi reabilitatsii ditei z onkohematolohichnymy zakhvoriuvanniamy [The Substantiation of the Method of Sanatorium-Resort Rehabilitation for Children with Oncohematological Diseases]. Ukrainskyi zhurnal medytsyny, biolohii ta sportu, 3(5), 194-197. https://doi.org/10.26693/jmbs03.05.194 [in Ukrainian].

Published

2021-06-07

How to Cite

1.
Bas OA, Ivasyk NO, Tyravska OI, Hertsyk AM. Analysis of physical therapy application in children with acute lymphoblastic leukemia (literature review). Zaporozhye Medical Journal [Internet]. 2021Jun.7 [cited 2024Nov.2];23(3):425-34. Available from: http://zmj.zsmu.edu.ua/article/view/215664

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Review