The relationship between systolic function and serum NGAL levels in patients with chronic heart failure of ischemic origin


  • V. A. Lysenko Zaporizhzhia State Medical University, Ukraine, Ukraine
  • V. V. Syvolap Zaporizhzhia State Medical University, Ukraine, Ukraine
  • M. S. Potapenko Zaporizhzhia State Medical University, Ukraine, Ukraine



serum NGAL, left ventricular systolic function, chronic heart failure of ischemic origin, renal dysfunction, biomarker of tubulo-interstitial injury


Neutrophil gelatinase-associated lipocalin (NGAL) is considered one of the most informative biomarkers of chronic kidney disease (CKD). NGAL can also serve as a biomarker of cardiovascular disease and heart failure (HF). However, the relationship between systolic function and serum NGAL concentrations in patients with chronic HF (CHF) of ischemic origin remains insufficiently studied.

The aim. To study the influence of tubulo-interstitial injury marker NGAL on systolic function in patients with CHF of ischemic origin.

Materials and methods. The study included 51 patients with CHF, stage II AB, NYHA II-IV FC. Doppler echocardiographic examination was performed on the device Esaote MyLab Eight (Italy) according to standard methods. NGAL levels were analyzed using an ELISA kit (E-EL-H0096, Elabscience, USA). Depending to the concentration of serum NGAL, the patients were divided into 2 subgroups. In the first group (n = 37), the NGAL level was higher than 168 ng/ml, in the second (n = 14) – less than 168 ng/ml.

Results. The mean serum NGAL concentration in the first subgroup was 192 (183; 200) ng/ml, in the second subgroup – 154 (134; 160) ng/ml. The patients with CHF of ischemic origin with tubulo-interstitial injury (according to the serum concentration of NGAL) did not differ significantly from the patients with CHF of ischemic origin without tubulo-interstitial injury in age (P = 0.950), height (P = 0.983), weight (P = 0.681), body surface area (P = 0.975). Most of left ventricular systolic function indicators showed a downward tendency (S 6.90 ± 2.85 cm/s vs. 7.67 ± 2.83 cm/s (P = 0.536); S lat 7.33 ± 2.08 cm/s vs. 11.00 ± 4.00 cm/s (P = 0.467); TEI LV 0.56 ± 0.26 c.u. vs. 0.49 ± 0.14 c.u. (P = 0.747)) in the patients with CHF of ischemic origin with elevated serum levels of NGAL compared to similar indicators in the patients with CHF of ischemic origin without tubulo-interstitial injury. The index of LVEF was significantly lower in the patients with CHF with elevated serum NGAL compared to that in the patients with CHF with normal serum NGAL (50.43 ± 17.85 % vs. 63.29 ± 13.24 % (P = 0.021)).

Conclusions. Serum NGAL was not only the sensitive marker of tubulo-interstitial injury in patients with CHF of ischemic origin, but also appeared to be a predictor of changes in systolic heart function.

Author Biographies

V. A. Lysenko, Zaporizhzhia State Medical University, Ukraine

MD, Postgraduate student of the Department of Propaedeutics of Internal Medicine, Radiation Diagnostics and Radiation Therapy

V. V. Syvolap, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Propaedeutics of Internal Medicine, Radiation Diagnostics and Radiation Therapy

M. S. Potapenko, Zaporizhzhia State Medical University, Ukraine

MD, PhD,  Associate Professor of the Department of Anesthesiology and Intensive Care


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How to Cite

Lysenko VA, Syvolap VV, Potapenko MS. The relationship between systolic function and serum NGAL levels in patients with chronic heart failure of ischemic origin. Zaporozhye Medical Journal [Internet]. 2021Apr.16 [cited 2024May20];23(2):184-8. Available from:



Original research