The role of diet in the prevention of migraine attacks

Authors

DOI:

https://doi.org/10.14739/2310-1210.2021.6.224601

Keywords:

migraine, diet, gut microbiota, prevention

Abstract

The review provides information concerning the influence of dietary factors and different types of diet on the origin and frequency of migraine headaches according to the up-to-date scientific data. The relevance of the problem is associated with high prevalence of migraine, which is a common cause of disability amongst young people. Gut – brain axis takes a significant place in the pathophysiology of migraine. The concept of a gut-brain axis explains a bidirectional relationship between the gastrointestinal system and the central nervous system. It has been suggested that changes in the gut-brain axis functioning may play a role in the pathogenesis of migraine. The review describes possible mechanisms of gut microbiota involvement in the pathogenesis of migraine.

Knowledge of the important role of food triggers in migraine has contributed to the development of a dietary therapeutic strategy for the prevention of migraine headache. The paper contains data concerning possible pathogenetically substantiated effects of various types of diet (elimination, epigenetic, ketogenic) in migraine prevention, given the lack of efficacy and side effects of current migraine drug therapy. The review discusses the possible positive effects of dietary approaches on migraine through their beneficial influence on the intestinal microbiota and functioning of the gut-brain axis.

Conclusions. An update on the role of diet in the pathogenesis and prevention of migraine attacks is an extremely important and promising scientific field, which requires further research with the development of personalized approaches taking into account the individual characteristics of each patient.

 

Author Biographies

O. O. Kopchak, Private Higher Educational Institution “Kyiv Medical University”, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Neurology, Psychiatry and Physical Rehabilitation

O. Ye. Hrytsenko, Private Higher Educational Institution “Kyiv Medical University”, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Neurology, Psychiatry and Physical Rehabilitation

References

Di Lorenzo, C., Coppola, G., Bracaglia, M., Di Lenola, D., Evangelista, M., Sirianni, G., Rossi, P., Di Lorenzo, G., Serrao, M., Parisi, V., & Pierelli, F. (2016). Cortical functional correlates of responsiveness to short-lasting preventive intervention with ketogenic diet in migraine: a multimodal evoked potentials study. The Journal of Headache and Pain, 17, Article 58. https://doi.org/10.1186/s10194-016-0650-9

Steiner, T. J., Stovner, L. J., Vos, T., Jensen, R., & Katsarava, Z. (2018). Migraine is first cause of disability in under 50s: will health politicians now take notice? The Journal of Headache and Pain, 19(1), Article 17. https://doi.org/10.1186/s10194-018-0846-2

GBD 2017 DALYs and HALE Collaborators. (2018). Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet, 392(10159), 1859-1922. https://doi.org/10.1016/S0140-6736(18)32335-3

Vetvik, K., & MacGregor, E. (2017). Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. The Lancet Neurology, 16(1), 76-87. https://doi.org/10.1016/s1474-4422(16)30293-9

Ferrari, M. D., Klever, R. R., Terwindt, G. M., Ayata, C., & van den Maagdenberg, A. M. (2015). Migraine pathophysiology: lessons from mouse models and human genetics. The Lancet Neurology, 14(1), 65-80. https://doi.org/10.1016/S1474-4422(14)70220-0

Aurora, S. K., & Brin, M. F. (2017). Chronic Migraine: An Update on Physiology, Imaging, and the Mechanism of Action of Two Available Pharmacologic Therapies. Headache, 57(1), 109-125. https://doi.org/10.1111/head.12999

Orr, S. L., Friedman, B. W., Christie, S., Minen, M. T., Bamford, C., Kelley, N. E., & Tepper, D. (2016). Management of Adults With Acute Migraine in the Emergency Department: The American Headache Society Evidence Assessment of Parenteral Pharmacotherapies. Headache, 56(6), 911-940. https://doi.org/10.1111/head.12835

Martin, V. T., & Vij, B. (2016). Diet and Headache: Part 1. Headache, 56(9), 1543-1552. https://doi.org/10.1111/head.12953

Yadav, R. K., Kalita, J., & Misra, U. K. (2010). A study of Triggers of Migraine in India. Pain Medicine, 11(1), 44-47. https://doi.org/10.1111/j.1526-4637.2009.00725.x

Abu-Salameh, I., Plakht, Y., & Ifergane, G. (2010). Migraine exacerbation during Ramadan fasting. The Journal of Headache and Pain, 11(6), 513-517. https://doi.org/10.1007/s10194-010-0242-z

Bektas, H., Karabulut, H., Doganay, B., & Acar, B. (2017). Allergens might trigger migraine attacks. Acta Neurologica Belgica, 117(1), 91-95. https://doi.org/10.1007/s13760-016-0645-y

Saglam, O., Karapinar, U., Dursun, E., Cetin, B., Coskun, N., & Altundag, A. (2015). The Role of Lifestyle Modifications in the Management of Migraine Associated Vertigo. Journal of Clinical and Analytical Medicine, 6(6), 763-765. https://doi.org/10.4328/jcam.2433

Park, J. W., Chu, M. K., Kim, J. M., Park, S. G., & Cho, S. J. (2016). Analysis of Trigger Factors in Episodic Migraineurs Using a Smartphone Headache Diary Applications. PLOS ONE, 11(2), Article e0149577. https://doi.org/10.1371/journal.pone.0149577

Goadsby, P. J., Holland, P. R., Martins-Oliveira, M., Hoffmann, J., Schankin, C., & Akerman, S. (2017). Pathophysiology of Migraine: A Disorder of Sensory Processing. Physiological Reviews, 97(2), 553-622. https://doi.org/10.1152/physrev.00034.2015

Dinan, T. G., & Cryan, J. F. (2017). The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterology Clinics of North America, 46(1), 77-89. https://doi.org/10.1016/j.gtc.2016.09.007

Cámara-Lemarroy, C. R., Rodriguez-Gutierrez, R., Monreal-Robles, R., & Marfil-Rivera, A. (2016). Gastrointestinal disorders associated with migraine: A comprehensive review. World Journal of Gastroenterology, 22(36), 8149-8160. https://doi.org/10.3748/wjg.v22.i36.8149

van Hemert, S., Breedveld, A. C., Rovers, J. M., Vermeiden, J. P., Witteman, B. J., Smits, M. G., & de Roos, N. M. (2014). Migraine associated with gastrointestinal disorders: review of the literature and clinical implications. Frontiers in Neurology, 5, Article 241. https://doi.org/10.3389/fneur.2014.00241

Bastiaanssen, T., Cowan, C., Claesson, M. J., Dinan, T. G., & Cryan, J. F. (2019). Making Sense of … the Microbiome in Psychiatry. International Journal of Neuropsychopharmacology, 22(1), 37-52. https://doi.org/10.1093/ijnp/pyy067

Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. F. (2019). Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis. Journal of Neuroinflammation, 16(1), Article 53. https://doi.org/10.1186/s12974-019-1434-3

Cussotto, S., Sandhu, K. V., Dinan, T. G., & Cryan, J. F. (2018). The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective. Frontiers in Neuroendocrinology, 51, 80-101. https://doi.org/10.1016/j.yfrne.2018.04.002

Gazerani, P. (2019). Probiotics for Parkinson's Disease. International Journal of Molecular Sciences, 20(17), Article 4121. https://doi.org/10.3390/ijms20174121

Gazerani, P. (2020). Migraine and Diet. Nutrients, 12(6), Article 1658. https://doi.org/10.3390/nu12061658

Arzani, M., Jahromi, S. R., Ghorbani, Z., Vahabizad, F., Martelletti, P., Ghaemi, A., Sacco, S., Togha, M., & School of Advanced Studies of the European Head-ache Federation (EHF-SAS). (2020). Gut-brain Axis and migraine headache: a comprehensive review. The Journal of Headache and Pain, 21(1), Article 15. https://doi.org/10.1186/s10194-020-1078-9

Jenkins, K., McCauley, D., Heffron, R., Stephan, H., & Rehner, R. (2016). Energy justice: A conceptual review. Energy Research & Social Science, 11, 174-182. https://doi.org/10.1016/j.erss.2015.10.004

Naghibi, M. M., Day, R., Stone, S., & Harper, A. (2019). Probiotics for the Prophylaxis of Migraine: A Systematic Review of Randomized Placebo Controlled Trials. Journal of Clinical Medicine, 8(9), Article 1441. https://doi.org/10.3390/jcm8091441

Maier, L., Pruteanu, M., Kuhn, M., Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., Patil, K. R., Bork, P., & Typas, A. (2018). Extensive impact of non-antibiotic drugs on human gut bacteria. Nature, 555(7698), 623-628. https://doi.org/10.1038/nature25979

Gazerani, P., Fuglsang, R., Pedersen, J. G., Sørensen, J., Kjeldsen, J. L., Yassin, H., & Nedergaard, B. S. (2019). A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Current Medical Research and Opinion, 35(4), 715-723. https://doi.org/10.1080/03007995.2018.1519503

Razeghi Jahromi, S., Ghorbani, Z., Martelletti, P., Lampl, C., Togha, M., & School of Advanced Studies of the European Headache Federation (EHF-SAS). (2019). Association of diet and headache. The Journal of Headache and Pain, 20(1), Article 106. https://doi.org/10.1186/s10194-019-1057-1

Gross, E. C., Klement, R. J., Schoenen, J., D'Agostino, D. P., & Fischer, D. (2019). Potential Protective Mechanisms of Ketone Bodies in Migraine Prevention. Nutrients, 11(4), Article 811. https://doi.org/10.3390/nu11040811

Fila, M., Chojnacki, C., Chojnacki, J., & Blasiak, J. (2019). Is an «Epigenetic Diet» for Migraines Justified? The Case of Folate and DNA Methylation. Nutrients, 11(11), Article 2763. https://doi.org/10.3390/nu11112763

Hardy, T. M., & Tollefsbol, T. O. (2011). Epigenetic diet: impact on the epigenome and cancer. Epigenomics, 3(4), 503-518. https://doi.org/10.2217/epi.11.71

Fila, M., Pawłowska, E., & Blasiak, J. (2019). Mitochondria in migraine pathophysiology - does epigenetics play a role? Archives of Medical Science, 15(4), 944-956. https://doi.org/10.5114/aoms.2019.86061

Menon, S., Nasir, B., Avgan, N., Ghassabian, S., Oliver, C., Lea, R., Smith, M., & Griffiths, L. (2016). The effect of 1 mg folic acid supplementation on clinical outcomes in female migraine with aura patients. The Journal of Headache and Pain, 17(1), Article 60. https://doi.org/10.1186/s10194-016-0652-7

Soda, K. (2018). Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism. International Journal of Molecular Sciences, 19(10), Article 3106. https://doi.org/10.3390/ijms19103106

Moore, K., Hughes, C. F., Ward, M., Hoey, L., & McNulty, H. (2018). Diet, nutrition and the ageing brain: current evidence and new directions. Proceedings of the Nutrition Society, 77(2), 152-163. https://doi.org/10.1017/S0029665117004177

Isobe, C., & Terayama, Y. (2010). A Remarkable Increase in Total Homocysteine Concentrations in the CSF of Migraine Patients With Aura. Headache, 50(10), 1561-1569. https://doi.org/10.1111/j.1526-4610.2010.01713.x

Shaik, M. M., Tan, H. L., Kamal, M. A., & Gan, S. H. (2014). Do Folate, Vitamins B6 and B12 Play a Role in the Pathogenesis of Migraine? The Role of Pharmacoepigenomics. CNS & Neurological Disorders Drug Targets, 13(5), 828-835. https://doi.org/10.2174/18715273113129990112

Gazerani, P. (2018). Current Evidence on the Role of Epigenetic Mechanisms in Migraine: The Way Forward to Precision Medicine. OBM Genetics, 2(4), Article 040. https://doi.org/10.21926/obm.genet.1804040

Danial, N. N., Hartman, A. L., Stafstrom, C. E., & Thio, L. L. (2013). How Does the Ketogenic Diet Work? Four Potential Mechanisms. Journal of Child Neurology, 28(8), 1027-1033. https://doi.org/10.1177/0883073813487598

Gross, E., Putananickal, N., Orsini, A. L., Schmidt, S., Vogt, D. R., Cichon, S., Sandor, P., & Fischer, D. (2019). Efficacy and safety of exogenous ketone bodies for preventive treatment of migraine: A study protocol for a single-centred, randomised, placebo-controlled, double-blind crossover trial. Trials, 20(1), Article 61. https://doi.org/10.1186/s13063-018-3120-7

Di Lorenzo, C., Pinto, A., Ienca, R., Coppola, G., Sirianni, G., Di Lorenzo, G., Parisi, V., Serrao, M., Spagnoli, A., Vestri, A., Schoenen, J., Donini, L. M., & Pierelli, F. (2019). A Randomized Double-Blind, Cross-Over Trial of very Low-Calorie Diet in Overweight Migraine Patients: A Possible Role for Ketones? Nutrients, 11(8), Article 1742. https://doi.org/10.3390/nu11081742

Lukacs, M., Tajti, J., Fulop, F., Toldi, J., Edvinsson, L., & Vecsei, L. (2017). Migraine, Neurogenic Inflammation, Drug Development - Pharmacochemical Aspects. Current Medicinal Chemistry, 24(33), 3649-3665. https://doi.org/10.2174/0929867324666170712163437

Seo, J. G., & Park, S. P. (2020). Vitamin D Deficiency and Its Correlates in Migraine Patients. Annals of Indian Academy of Neurology, 23(2), 233-235. https://doi.org/10.4103/aian.AIAN_229_19

Ghorbani, Z., Togha, M., Rafiee, P., Ahmadi, Z. S., Rasekh Magham, R., Haghighi, S., Razeghi Jahromi, S., & Mahmoudi, M. (2019). Vitamin D in migraine headache: a comprehensive review on literature. Neurological Sciences, 40(12), 2459-2477. https://doi.org/10.1007/s10072-019-04021-z

Ghorbani, Z., Rafiee, P., Fotouhi, A., Haghighi, S., Rasekh Magham, R., Ahmadi, Z. S., Djalali, M., Zareei, M., Razeghi Jahromi, S., Shahemi, S., Mahmoudi, M., & Togha, M. (2020). The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial. The Journal of Headache and Pain, 21(1), Article 22. https://doi.org/10.1186/s10194-020-01090-w

Edvinsson, L. (2017). The Trigeminovascular Pathway: Role of CGRP and CGRP Receptors in Migraine. Headache, 57(S2), 47-55. https://doi.org/10.1111/head.13081

Iyengar, S., Johnson, K. W., Ossipov, M. H., & Aurora, S. K. (2019). CGRP and the Trigeminal System in Migraine. Headache, 59(5), 659-681. https://doi.org/10.1111/head.13529

Ramachandran, R. (2018). Neurogenic inflammation and its role in migraine. Seminars in Immunopathology, 40(3), 301-314. https://doi.org/10.1007/s00281-018-0676-y

Gaul, C., Diener, H. C., Danesch, U., & Migravent® Study Group. (2015). Improvement of migraine symptoms with a proprietary supplement containing riboflavin, magnesium and Q10: a randomized, placebo-controlled, double-blind, multicenter trial. The Journal of Headache and Pain, 16, Article 516. https://doi.org/10.1186/s10194-015-0516-6

Goschorska, M., Gutowska, I., Baranowska-Bosiacka, I., Barczak, K., & Chlubek, D. (2020). The Use of Antioxidants in the Treatment of Migraine. Antioxidants, 9(2), Article 116. https://doi.org/10.3390/antiox9020116

D'Onofrio, F., Raimo, S., Spitaleri, D., Casucci, G., & Bussone, G. (2017). Usefulness of nutraceuticals in migraine prophylaxis. Neurological Sciences, 38(Suppl. 1), 117-120. https://doi.org/10.1007/s10072-017-2901-1

Rajapakse, T., & Pringsheim, T. (2016). Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use. Headache, 56(4), 808-816. https://doi.org/10.1111/head.12789

Guilbot, A., Bangratz, M., Ait Abdellah, S., & Lucas, C. (2017). A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study. BMC Complementary and Alternative Medicine, 17(1), Article 433. https://doi.org/10.1186/s12906-017-1933-7

Downloads

Published

2021-10-29

How to Cite

1.
Kopchak OO, Hrytsenko OY. The role of diet in the prevention of migraine attacks. Zaporozhye medical journal [Internet]. 2021Oct.29 [cited 2024Apr.26];23(6):865-71. Available from: http://zmj.zsmu.edu.ua/article/view/224601

Issue

Vol. 23 No. 6 (2021)

Section

Review

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)