Development of methods for standardization of the active substance, namely the model mixture based on decamethoxine and thiotriazoline

Authors

DOI:

https://doi.org/10.14739/2310-1210.2021.5.225459

Keywords:

decamethoxine, thiotriazoline, model mixtures, spectrophotometry

Abstract

Today, the important problem is the creation of new decamethoxine and thiotriazoline based drugs for the treatment of stomatitis.

The aim of the work is to develop a method for quantitative determination of decamethoxine and thiotriazoline in the model mixture (1:25) by spectrophotometry.

Materials and methods. Series 6 model mixtures were made at the ratio of decamethoxine and thiotriazoline 1:25. We used certified substances: thiotriazoline series GTT 3460911 (manufacturer: State Enterprise Chemical Reagents Plant, Kharkiv), decamethoxine series № 010915 (manufacturer: LLC “PHARMCHIM”). Optizen POP spectrophotometer, polyvinyl alcohol, hydrochloric acid, and eosin were used.

Results. A method for quantitative determination of decamethoxine and thiotriazoline in MS was developed. It was established that the content of active substances in MS is thiotriazoline from 0.5021 to 0.5096, decamethoxine from 0.0207 to 0.0211.

Conclusions. A method for quantitative determination of decamethoxine and thiotriazoline in MS has been developed. The method of quantitative determination of decamethoxine and thiotriazoline in MS is reproducible.

Author Biographies

L. I. Kucherenko, Zaporizhzhia State Medical University, Ukraine

PhD, DSc, Professor, Head of the Department of Pharmaceutical Chemistry, Vice-President of SPA “Farmatron”, Ukraine

O. O. Chonka, Zaporizhzhia State Medical University, Ukraine

Postgraduate student of the Department of Pharmaceutical Chemistry

O. O. Portna, Zaporizhzhia State Medical University, Ukraine

Associate Professor of the Department of Pharmaceutical Chemistry

References

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Published

2021-09-01

How to Cite

1.
Kucherenko LI, Chonka OO, Portna OO. Development of methods for standardization of the active substance, namely the model mixture based on decamethoxine and thiotriazoline. Zaporozhye Medical Journal [Internet]. 2021Sep.1 [cited 2024Jul.21];23(5):703-7. Available from: http://zmj.zsmu.edu.ua/article/view/225459

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Original research