Features of comorbid pathology spectrum and age structure of oxygen-dependent patients with severe coronavirus disease 2019 (COVID-19) depending on outcomes of the disease


  • O. V. Riabokon Zaporizhzhia State Medical University, Ukraine, Ukraine
  • V. V. Cherkaskyi Municipal non-profit enterprise “Regional Infectious Diseases Clinical Hospital” of Zaporizhzhia Regional Council, Ukraine, Ukraine
  • T. Ye. Onishchenkо Zaporizhzhia State Medical University, Ukraine, Ukraine
  • Yu. Yu. Riabokon Zaporizhzhia State Medical University, Ukraine, Ukraine




COVID-19, comorbidity


The aim was to analyze spectrum of comorbid pathology and age structure of oxygen-dependent patients with severe coronavirus disease 2019 (COVID-19) depending on outcomes of the disease.

Materials and methods. The study included 85 oxygen-dependent patients with severe COVID-19. The patients were divided into groups: I – 70 patients with recovery; II – 15 patients in whom the disease was fatal. Statistical data processing was performed in the program Statistica for Windows 13 (StatSoft Inc., No. JPZ804I382130ARCN10-J).

Results. Among the patients with fatal outcomes of the disease, elderly and senile were dominated – 93.3 % (14 of 15) versus 67.1 % (47 of 70) among patients who recovered (P < 0.05). Analysis of comorbid pathology structure in oxygen-dependent patients with severe COVID-19 showed that patients who died more often had hypertension (93.3 % vs. 30.0 %, P < 0.001), postinfarction cardiosclerosis (26.7 % vs. 2.9 %, P < 0.001), rhythm disturbance as persistent atrial fibrillation (20.0 % vs. 1.4 %, P < 0.01) as compared to those who survived. The patients of group II were more commonly diagnosed with chronic kidney disease (20.0 % vs. 4.3 %, P < 0.05) as the comorbid pathology. The presence of ischemic stroke in COVID-19 infection influenced the disease outcome (20.0 % vs. 4.3 %, P < 0.05). Fatal outcomes in the patients with COVID-19 were associated with a combination of 3 or more comorbid conditions in 46.7 % versus 17.4 % among oxygen-dependent survivors with severe disease (P < 0.01).

Conclusions. Elderly and senile oxygen-dependent patients are more likely to die from severe COVID-19 (P < 0.05). Comorbid hypertension, postinfarction cardiosclerosis, arrhythmia in the form of persistent atrial fibrillation, chronic kidney disease and ischemic stroke or the combination of 3 or more comorbid conditions listed are more common among patients with COVID-19 who died (P < 0.05) as compared to survivors.

Author Biographies

O. V. Riabokon, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Infectious Diseases

V. V. Cherkaskyi, Municipal non-profit enterprise “Regional Infectious Diseases Clinical Hospital” of Zaporizhzhia Regional Council, Ukraine

Head of the Department of Anesthesiology and Intensive Care

T. Ye. Onishchenkо, Zaporizhzhia State Medical University, Ukraine

MD, PhD, Associate Professor of the Department of Infectious Diseases

Yu. Yu. Riabokon, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Professor of the Department of Children Infectious Diseases


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How to Cite

Riabokon OV, Cherkaskyi VV, Onishchenkо TY, Riabokon YY. Features of comorbid pathology spectrum and age structure of oxygen-dependent patients with severe coronavirus disease 2019 (COVID-19) depending on outcomes of the disease. Zaporozhye Med J [Internet]. 2021Apr.16 [cited 2023Dec.5];23(2):214-9. Available from: http://zmj.zsmu.edu.ua/article/view/228712



Original research