Simulation of endothelium-dependent vasodilation in young male persons based on the parameters of body weight components
DOI:
https://doi.org/10.14739/2310-1210.2021.6.234155Keywords:
endothelial dysfunction, body composition, vasodilation, young adult, obesity, correlation study, regression analysisAbstract
The aim of the work. To analyze the results of endothelium-dependent vasodilation of the brachial artery in persons with different content of body weight components and to develop models for predicting the response of endothelium-dependent vasodilation based on the parameters of body weight components.
Materials and methods. In total, 31 young men were examined and divided into three groups depending on the total body fat value: 16 people (51.6 %) – group I, 11 people (35.5 %) – group II and 4 people (12.9 %) – group III. Determination of such parameters as body mass index (BMI, kg/m2), the percentage of total fat (TFP, %), the visceral fat content (VFC, units) and the content of free-fat mass (FFM,%) was performed using a bioimpedance analyzer TANITA BC-601.
Endothelial regulation was assessed on the basis of vasomotor dilation of the brachial artery activity before and after the occlusion test using a four-channel rheograph ReoCom (XAI-MEDICA).
Results. During the occlusion test, three types of endothelium-dependent vasodilation (EDVD) were identified in individuals examined. 62.50 % of men in group I had a normoergic reaction of the brachial artery, 31.25 % had a hyperergic and 6.25 % had a hypoergic reaction. Among group II persons, a normoergic type of post-occlusive reaction was in 45.4 %, hyperergic – in 36.4 %, and hypoergic type – in 18.2 %. Regarding group III, 75 % of individuals had the hyperergic type of endothelium-dependent vasodilation, 25 % had the normoergic type, and no hypoergic type of reaction was observed at all. To determine the endothelial vasoregulatory function on the basis of correlation-regression analysis, models were constructed with coefficients of determination R2 of 0.277 (BMI), 0.126 (TFP), 0.189 (VFC) and 0.146 (FFM). The models themselves had the following form: between EDVD and BMI – y = -4.5297 + 0.865x; TFP – y = 10.7389 + 0.4x; VFC – y =13.8119 + 1.0041x; FFM – y = 52.7904 – 0.4464x. In addition, statistically significant correlations were found between them – from r = +0.335 to r = +0.526.
Conclusions. The data obtained allow us to note that the functional state of the endothelium and its activity depends on the content of body weight components in the organism.
References
Tsentr hromadskoho zdorov’ia MOZ Ukrainy. (2021, January 4). Sertsevo-sudynni zakhvoriuvannia – holovna prychyna smerti ukraintsiv. Vysnovky z doslidzhennia Hlobalnoho tiaharia khvorob u 2019 rotsi [Cardiovascular disease is the leading cause of mortality in Ukrainians. Findings from the 2019 Global Burden of Disease Study]. https://phc.org.ua/news/sercevo-sudinni-zakhvoryuvannya-golovna-prichina-smerti-ukrainciv-visnovki-z-doslidzhennya [in Ukrainian].
Eckel, R. H., Jakicic, J. M., Ard, J. D., de Jesus, J. M., Houston Miller, N., Hubbard, V. S., Lee, I. M., Lichtenstein, A. H., Loria, C. M., Millen, B. E., Nonas, C. A., Sacks, F. M., Smith, S. C., Jr, Svetkey, L. P., Wadden, T. A., Yanovski, S. Z., Kendall, K. A., Morgan, L. C., Trisolini, M. G., Velasco, G., … American College of Cardiology/American Heart Association Task Force on Practice Guidelines. (2014). 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, 129(25 Suppl. 2), S76-S99. https://doi.org/10.1161/01.cir.0000437740.48606.d1
Yermolenko, N. O., & Zarudna, O. I. (2016). Nadlyshkova masa tila ta osnovni faktory, shcho spychyniaiut yii rozvytok [Over weight and key factors contributing to its development]. Medsestrynstvo, (2), 38-40. [in Ukrainian].
Urbanovich, A. M. (2013). Hormony zhyrovoi tkanyny ta yikh klinichne znachennia [Hormones of adipose tissue and their clinical significance]. Endokrynolohiia, 18(1), 69-72. [in Ukrainian].
Cao, H. (2014). Adipocytokines in obesity and metabolic disease. Journal of Endocrinology, 220(2), T47-T59. https://doi.org/10.1530/JOE-13-0339
Abdulkadirova, F. R., Ametov, A. S., Doskina, E. V., & Pokrovskaya, R. A. (2014). Rol' lipotoksichnosti v patogeneze sakharnogo diabeta 2 tipa i ozhirenii [The role of the lipotoxicity in the pathogenesis of type 2 diabetes mellitus and obesity]. Ozhirenie i metabolizm, 11(2), 8-12. [in Russian].
Kovalenko, O. M., & Rodionova, V. V. (2016). Korektsiia endotelialnoi dysfunktsii v terapevtychnii stratehii sertsevo-sudynnoi patolohii [Correction of endothelial dysfunction in therapeutic strategy for cardiovascular pathology]. Kardiologiya: ot nauki k praktike, (2), 31-38. [in Russian].
Zhdan, V. M., & Katerenchuk, I. P. (2014). Optymizatsiia korektsii endotelialnoi dysfunktsii u patsiientiv z metabolichnym syndromom u praktytsi simeinoho likaria [Optimization of endothelial function correction in patients with metabolic syndrome in family doctors practice]. Zdobutky klinichnoi i eksperymentalnoi medytsyny, (1), 39-43. [in Ukrainian].
Ivanchikova, S. (2016). Bioimpedansnyi analiz komponentnoho skladu tila studentiv universytetiv u protsesi zaniat fitnesom [Bioimpedance analysis component of body composition of university students in the process of fitness]. Naukovyi chasopys Natsionalnoho pedahohichnoho universytetu imeni M. P. Drahomanova. Seriia № 15. Naukovo-pedahohichni problemy fizychnoi kultury (fizychna kultura i sport), 3К(1), 13-16. [in Ukrainian].
Bartels, E. M., Sørensen, E. R., & Harrison, A. P. (2015). Multi-frequency bioimpedance in human muscle assessment. Physiological Reports, 3(4), Article e12354. https://doi.org/10.14814/phy2.12354
World Medical Association. (2018, July 9). WMA Declaration of Helsinki - Ethical Principles for Medical Research Involving Human Subjects. https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/
Aksenov, E. V. (2019). Endotelialna dysfunktsiia ta shliakhy yii profilaktyky pry provedenni renthenendovaskuliarnykh protsedur po rekanalizatsii koronarnykh arterii [Endothelial Dysfunction and Ways of its Prevention during Percutaneous Coronary Interventions by Recanalization of Coronary Arteries]. Ukrainskyi zhurnal medytsyny, biolohii ta sportu, 4(5), 102-108. https://doi.org/10.26693/jmbs04.05.102 [in Ukrainian].
Kvashnina, L. V., & Ignatova, T. B. (2016). Profilaktyka porushen endotelialnoi funktsii u ditei u period perekhodu vid zdorovia do syndromu vehetatyvnoi dysfunktsii [Prophylaxis of disturbances of endothelial function within the children during transition from health to a syndrome of vegetative dysfunction]. Sovremennaya pediatriya, (5), 16-24. https://doi.org/10.15574/SP.2016.77.16 [in Ukrainian].
Fedoniuk, L. Ya. (2019). Rol dysfunktsii endoteliiu u formuvanni vad klapaniv sertsia [The role of the endothelial dysfunction in the formation of the heart valves defects]. Zdobutky klinichnoi i eksperymentalnoi medytsyny, (3), 40-47. https://doi.org/10.11603/1811-2471.2019.v.i3.10507 [in Ukrainian].
Dolzhenko, M. M., Bazylevych, A. Ya., Lymar, Yu. V., Konoplianyk, L. I., & Volosheniuk, I. O. (2011). Nealkoholna zhyrova khvoroba pechinky yak novyi faktor ryzyku ishemichnoi khvoroby sertsia [Non-alcoholic fatty liver disease as a new risk factor for coronary heart disease]. Liky Ukrainy, (8), 73-77. [in Ukrainian].
Zharinova, V. Yu (2015). Endotelial'naya disfunktsiya kak mul'tidistsiplinarnaya problema [Endothelial dysfunction as a multidisciplinary problem]. Krovoobih ta hemostaz, (1-2), 9-15. [in Russian].
Van der Heiden, K., Gijsen, F. J., Narracott, A., Hsiao, S., Halliday, I., Gunn, J., Wentzel, J. J., & Evans, P. C. (2013). The effects of stenting on shear stress: relevance to endothelial injury and repair. Cardiovascular Research, 99(2), 269-275. https://doi.org/10.1093/cvr/cvt090
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)
