Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.1.235880

Keywords:

CD56-positive cell, lung, guinea pigs, allergy, immunohistochemical staining, neuroendocrine cells

Abstract

The aim of this work is to study morphometric characteristics and distribution of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation.

Materials and methods. We studied the distribution and quantitative changes of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation using histological, histochemical, immunohistochemical, morphometric and statistical methods.

Results. The number of CD56-positive cells increased in the dynamics of experimental ovalbumin-induced allergic inflammation. The increase in the mean number of CD56-positive cells was found in the early period of allergic inflammation (on the 30th day, experimental group II) by 64.5 % (P*/** < 0.001) compared to the control group and by 56.4 % (P* < 0.01) compared to the 23rd day of examinations (experimental group I). The following increase in the mean number of CD56-positive cells by 60.2 % (P*/** < 0.001) was detected in group III compared to the 23rd day of the experiment (group I). However, the mean number of CD56-positive cells was shown to be decreased by 51.5 % (P*/** < 0.001) in group IV compared to the 36th experimental day (group III).

Conclusions. CD56-positive cells are located in the pulmonary interstitium. The number of CD56-positive cells is statistically significantly increased in group III in the late stages of the allergic inflammation indicating an active involvement of these cells in maintaining allergen-induced airway inflammation.

 

Author Biographies

S. S. Popko, Zaporizhzhia State Medical University, Ukraine

MD, PhD, Associate Professor of the Department of Histology, Cytology and Embryology

V. M. Yevtushenko, Zaporizhzhia State Medical University, Ukraine

MD, PhD, DSc, Head of the Department of Histology, Cytology and Embryology

H. A. Zidrashko, Zaporizhzhia State Medical University, Ukraine

MD, PhD, Associate Professor of the Department of Histology, Cytology and Embryology

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Published

2022-01-26

How to Cite

1.
Popko SS, Yevtushenko VM, Zidrashko HA. Characteristics of CD56-positive cells in guinea pig lung in the dynamics of experimental allergic inflammation. Zaporozhye Medical Journal [Internet]. 2022Jan.26 [cited 2024Nov.13];24(1):79-83. Available from: http://zmj.zsmu.edu.ua/article/view/235880

Issue

Vol. 24 No. 1 (2022)

Section

Original research

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