Reye’s-like syndrome in 13-year-old child (a case report)

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.1.238606

Keywords:

Reye’s syndrome, Reye’s-like syndrome, coronavirus infections, antipyretics

Abstract

The article reviews the literature about classical and atypical Reye’s syndrome, discusses the causes that contribute to its occurrence, provides criteria for diagnosis with the presentation of a Reye’s-like syndrome case in the 13-year-old child. Reye’s syndrome is a dangerous pathological condition characterized by acute encephalopathy and fatty degeneration of internal organs, mainly the liver.

There are different viral and bacterial infections that precede the development of Reye’s syndrome, namely influenza, acute respiratory infections, chickenpox, entero- and rotavirus infections, whooping cough, mycoplasma infection, salmonellosis. For a treatment of these infections in the presence of fever, a number of drugs to lower the temperature, such as acetylsalicylic acid, ibuprofen, acetaminophen, diclofenac sodium is usually used.

Case presentation. We observed the case of a teenage girl with Reye’s-like syndrome associated with coronavirus infection and antipyretic drug intake in the clinic.

Conclusions. Given the changes in the internal organs, namely the development of hepatic steatosis, therapy of such patients should be aimed at preventing fatty degeneration. In addition to classic Reye’s syndrome, there is an atypical Reye’s syndrome or Reye’s-like syndrome, which mainly occurs in children under 5 years old with congenital disorders of fatty acid metabolism. Dosages of prescribing antipyretic drugs should be strictly based on the child’s age and weight.

Author Biographies

O. M. Shulhai, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine

MD, PhD, Associate Professor of the Department of Children’s Diseases with Pediatric Surgery

M. I. Kinash, I. Horbachevsky Ternopil National Medical University of Health Ministry of Ukraine

MD, PhD, Associate Professor of the Department of Children’s Diseases with Pediatric Surgery

A.-M. A. Shulhai, I. Horbachevsky Ternopil National Medical University of Health Ministry of Ukraine

MD, PhD, Assistant of the Department of Pediatrics No. 2

References

Koloskova, O. K., Tkachuk, R. V., Bilous, T. M., Kolyubakina, L. V., & Bogutska N. K. (2021). Kliniko-laboratorni osoblyvosti perebihu syndromu Reia v ditei: klinichnyi vypadok [Сlinical and laboratory features of Reye’s syndrome in children: a clinical case]. Zdorovia dytyny, 16(4), 309-316. https://doi.org/10.22141/2224-0551.16.4.2021.237278 [in Ukrainian].

Postnikov, S. S., Mikhailova, S. V., Bryusov, G. P., Kostyleva, M. N., Gratsianskaya, A. N., & Ermilin, A. E. (2018). Reya-podobnyi sindrom u rebenka 3 let [Reye-like syndrome in three-year-old child]. Bezopasnost' i risk farmakoterapii, 6(3), 103-110. https://doi.org/10.30895/2312-7821-2018-6-3-103-110 [in Russian].

de Bont, E., Bohnen, J., Verhoeven, R., Dinant, G. J., & Cals, J. (2020). Childhood fever: Parental paracetamol administration after consulting out-of-hours general practice. European Journal of General Practice, 26(1), 21-25. https://doi.org/10.1080/13814788.2019.1676415

Chornomydz, I., Boyarchuk, O., & Chornomydz, A. (2017). Reye (Ray’s) syndrome: a problem everyone should remember. Georgian Medical News, (11), 110-118.

Weiner, D. L. (2018, April 02). Reye Syndrome. EMedicine. https://emedicine.medscape.com/article/803683-overview

Royal College of Paediatrics and Child Health. (n.d.). Reye-like syndromes. RCPCH. https://reyessyndrome.rcpch.ac.uk/reye-like-syndromes/

Venturini, E., Montagnani, C., Garazzino, S., Donà, D., Pierantoni, L., Lo Vecchio, A., Nicolini, G., Bianchini, S., Krzysztofiak, A., Galli, L., Villani, A., Castelli-Gattinara, G., & Italian SITIP-SIP SARS-Cov-2 pediatric infection study group. (2020). Treatment of children with COVID-19: position paper of the Italian Society of Pediatric Infectious Disease. Italian Journal of Pediatrics, 46(1), Article 139. https://doi.org/10.1186/s13052-020-00900-w

Pessoa, F. S., Lacerda, E., Gonçalves, V. C., & Tanaka, B. N. (2021). Case Report: MIS-C Temporarily Associated With COVID-19 Complicated by Reye's Syndrome. Frontiers in Pediatrics, 9, Article 650697. https://doi.org/10.3389/fped.2021.650697

Sammons, H. M., & Choonara, I. (2016). Learning Lessons from Adverse Drug Reactions in Children. Children, 3(1), Article 1. https://doi.org/10.3390/children3010001

Bianconi, V., Violi, F., Fallarino, F., Pignatelli, P., Sahebkar, A., & Pirro, M. (2020). Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19? Drugs, 80(14), 1383-1396. https://doi.org/10.1007/s40265-020-01365-1

National Institute for Health and Care. (2020, May 01). COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital. NICE. https://www.nice.org.uk/guidance/ng173

Uppala, R., Dudiak, B., Beck, M. E., Bharathi, S. S., Zhang, Y., Stolz, D. B., & Goetzman, E. S. (2017). Aspirin increases mitochondrial fatty acid oxidation. Biochemical and Biophysical Research Communications, 482(2), 346-351. https://doi.org/10.1016/j.bbrc.2016.11.066

Mund, M. E., Gyo, C., Brüggmann, D., Quarcoo, D., & Groneberg, D. A. (2016). Acetylsalicylic acid as a potential pediatric health hazard: legislative aspects concerning accidental intoxications in the European Union. Journal of Occupational Medicine and Toxicology, 11, Article 32. https://doi.org/10.1186/s12995-016-0118-5

Rootring, E., Sargel, C. L., & Tobias, J. D. (2021). Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration. The Journal of Pediatric Pharmacology and Therapeutics, 26(5), 497-501. https://doi.org/10.5863/1551-6776-26.5.497

Weatherburn, C. J., Guthrie, B., Dreischulte, T., & Morales, D. R. (2020). Impact of medicines regulatory risk communications in the UK on prescribing and clinical outcomes: Systematic review, time series analysis and meta-analysis. British Journal of Clinical Pharmacology, 86(4), 698-710. https://doi.org/10.1111/bcp.14104

Ferretti, S., Gatto, A., Curatola, A., Pansini, V., Graglia, B., & Chiaretti, A. (2021). Atypical Reye syndrome: three cases of a problem that pediatricians should consider and remember. Acta Biomedica, 92(Suppl. 1), Article e2021110. https://doi.org/10.23750/abm.v92iS1.10205

McCrae, J. C., Morrison, E. E., MacIntyre, I. M., Dear, J. W., & Webb, D. J. (2018). Long-term adverse effects of paracetamol - a review. British Journal of Clinical Pharmacology, 84(10), 2218-2230. https://doi.org/10.1111/bcp.13656

Magrum, B. G., & Pickworth, K. K. (2020). Aspirin rechallenge in an adult patient previously diagnosed with Reye syndrome. American Journal of Health-System Pharmacy, 77(2), 123-127. https://doi.org/10.1093/ajhp/zxz276

Saragiotto, B. T., Machado, G. C., Ferreira, M. L., Pinheiro, M. B., Shaheed, C. A., & Maher, C. G. (2016). Paracetamol for low back pain. Cochrane Database of Systematic Reviews, 2016(6), Article CD012230. https://doi.org/10.1002/14651858.CD012230

Mund, M. E., Quarcoo, D., Gyo, C., Brüggmann, D., & Groneberg, D. A. (2015). Paracetamol as a toxic substance for children: aspects of legislation in selected countries. Journal of Occupational Medicine and Toxicology, 10, Article 43. https://doi.org/10.1186/s12995-015-0084-3

Downloads

Published

2022-01-26

How to Cite

1.
Shulhai OM, Kinash MI, Shulhai A-MA. Reye’s-like syndrome in 13-year-old child (a case report). Zaporozhye Medical Journal [Internet]. 2022Jan.26 [cited 2024Jul.20];24(1):138-42. Available from: http://zmj.zsmu.edu.ua/article/view/238606

Issue

Section

Case Reports