Association of COL11A1 C4603T polymorphism with the risk of cervical and lumbar disc herniation

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.2.249482

Keywords:

gene polymorphism, collagen type XI, hernia, intervertebral disc

Abstract

Aim. To evaluate the association of COL11A1 gene C4603T polymorphism with the risk of cervical and lumbar disc herniation among Ukrainian people.

Materials and methods. In total, 97 patients (48 women and 49 men with a mean age of 34.49 ± 6.75 years) with lumbar and cervical disc herniation and 60 (30 women and 30 men with a mean of 35.00 ± 6.51 years) control subjects were included in the study. All participants underwent T2-weighted magnetic resonance imaging (MRI). Single nucleotide polymorphism С4603Т (rs1676486) of COL11A1 gene was detected by real-time polymerase chain reaction using Tag Man Universal PCR Master Mix (Applied Biosystems, USA) and Tag Man SNP Genotyping Assays (Applied Biosystems, USA).

Results. The study revealed the association of the COL11A1 gene C4603T polymorphism with a risk of lumbar L5-S1 herniation in the dominant (OR = 3.20; 95 % CI (1.34–7.50); P < 0.008) and multiplicative models (OR = 2.82; 95 % CI (1.34–5.93); P < 0.006). A statistical association of the polymorphism with lumbar L4-L5 herniation was not found. Carriers of the 4603Т allele had a four-fold higher risk of cervical herniation in the dominant model (OR =4.00; 95 % CI (1.37–11.79); P < 0.01), and three-fold higher – in the multiplicative model (OR = 3.12; 95 % CI (1.26–7.69); P < 0.05).

Conclusions. The study has shown the statistically significant association of the COL11A1 C4603T polymorphism with cervical and lumbar disc herniation among Ukrainian people. The 4603T allele presence should be considered when a sports career planning or occupational choice related to a heavy load on the cervical or lumbar spine.

Author Biographies

Ye. H. Pedachenko, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, PhD, DSc, Professor, Academician of the National Academy of Medical Sciences of Ukraine, neurosurgeon, Research Supervisor of the Department of Miniinvasive and Laser Spinal Neurosurgery

I. H. Vasylieva, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

PhD, Head of the Department of Neurobiochemistry

M. V. Khyzhnyak, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

PhD, Head of the Department of Neurobiochemistry

O. S. Halanta, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

Researcher of the Department of Neurobiochemistry

N. H. Chopyk, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

PhD, Leading Researcher of the Department of Neurobiochemistry

О. І. Tsiubko, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

Researcher of the Department of Neurobiochemistry

A. В. Hriazov, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

MD, PhD, DSc, Head of the Department of Radiology

O. S. Nekhlopochyn, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

PhD, Researcher of the Department of Spinal Neurosurgery

Т. A. Ksenzov, Zaporizhzhia Regional Clinical Hospital, Zaporizhzhia, Ukraine

neurosurgeon of the Department of Neurosurgery

A. B. Dmytrenko, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

Junior Researcher of the Department of Neurobiochemistry

T. А. Makarova, SI “Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine”, Kyiv

Junior Researcher of the Department of Neurobiochemistry

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Published

2022-04-04

How to Cite

1.
Pedachenko YH, Vasylieva IH, Khyzhnyak MV, Halanta OS, Chopyk NH, Tsiubko ОІ, Hriazov AВ, Nekhlopochyn OS, Ksenzov ТA, Dmytrenko AB, Makarova TА. Association of COL11A1 C4603T polymorphism with the risk of cervical and lumbar disc herniation. Zaporozhye Medical Journal [Internet]. 2022Apr.4 [cited 2024Nov.26];24(2):163-7. Available from: http://zmj.zsmu.edu.ua/article/view/249482

Issue

Vol. 24 No. 2 (2022)

Section

Original research

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