Post-COVID syndrome

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.6.252741

Keywords:

post-acute COVID-19 syndrome, pneumonia, SARS-CoV-2, outpatient care

Abstract

The aim is to study the frequency and symptoms of post-COVID syndrome in patients with pneumonia caused by SARS-CoV-2, who were treated in an outpatient setting.

Materials and methods. Personal monitoring results of the health state of 62 patients who suffered pneumonia caused by the SARS-CoV-2 and were treated in the outpatient setting between May 2020 and September 2021 were analyzed. The patients were divided into 3 clinical groups depending on age, concomitant diseases, and extent of the process in the lungs. The examination results were processed on a personal computer using the statistical package Statistica program, version 10.

Results. The prevalence of post-COVID syndrome with the symptoms that characterize it is significantly higher in patients who have not been vaccinated with the COVID-19 vaccine, who have suffered pneumonia caused by SARS-CoV-2 of a moderate-to-severe course with the process extent in the lungs from 25 % to 50 %, with its repeated cases, regardless of age and the presence of concomitant pathologies. Prolonged COVID-19 (early post-COVID syndrome) and post-COVID syndrome are main complications of COVID-19 with the most common symptoms such as general fatigue, depression, impaired memory concentration, sleep disorder, myalgia/arthralgia.

Conclusions. Even a mild course of pneumonia caused by SARS-CoV-2 is accompanied by post-COVID syndrome, which requires long-term supervision and practice of rehabilitation techniques for such patients. Treatment of pneumonia caused by the SARS-CoV-2 with the moderate-to-severe course in outpatient conditions leads to an increase in the frequency and severity of the post-COVID syndrome course. Vaccination with a vaccine against COVID-19 to prevent the development of a severe course of pneumonia caused by the SARS-CoV-2 remains an urgent issue. Identified dental manifestations (stomatitis, periodontitis, and periodontal disease) should be considered by dentists in the early period of post-COVID syndrome, and dental pathology examination should be continued during the treatment of pneumonia caused by SARS-CoV-2 in post-COVID syndrome.

Author Biographies

V. P. Melnyk, PHEE “Kyiv Medical University”, Ukraine

MD, PhD, DSc, Professor, Head of the Department of Infectious Diseases, Phthisiology and Pulmonology

О. V. Panasiuk, PHEE “Kyiv Medical University”, Ukraine

MD, PhD, DSc, Professor of the Department of Infectious Diseases, Phthisiology and Pulmonology

H. V. Sadomova-Andrianova, PHEE “Kyiv Medical University”, Ukraine

MD, PhD, Associate Professor of the Department of Infectious Diseases, Phthisiology and Pulmonology

Yu. B. Zahuta, PHEE “Kyiv Medical University”, Ukraine

MD, PhD, Associate Professor of the Department of Infectious Diseases, Phthisiology and Pulmonology

I. V. Antoniuk, PHEE “Kyiv Medical University”, Ukraine

MD, Assistant of the Department of Infectious Diseases, Phthisiology and Pulmonology

I. O. Sliusarchuk, PHEE “Kyiv Medical University”, Ukraine

MD, Assistant of the Department of Infectious Diseases, Phthisiology and Pulmonology

I. V. Melnyk, PHEE “Kyiv Medical University”, Ukraine

MD, PhD, Associate Professor of the Department of Orthopedic Dentistry

References

Rekalova O. M. (2020). COVID-19 – nova virusna infektsiia: patohenez, diahnostyka, likuvannia [COVID-19 – a new viral infection: pathogenesis, diagnosis, treatment]. Tuberkuloz, lehenevi khvoroby, VIL-infektsiia, (2), 7-9. [in Ukrainian]. https://doi.org/10.30978/TB2020-2-7

WHO. (2021). Coronavirus (COVID-19) Dashboard (Ukraine). https://covid19.who.int/region/euro/country/ua

McIntosh, K. (2022). Covid-19: Epidemiology, virology, and prevention. Update, 1-80. https://www.uptodate.com/contents/covid-19-epidemiology-virology-and-prevention

Zhou, P., Yang, X. L., Wang, X. G., Hu, B., Zhang, L., Zhang, W., Si, H. R., Zhu, Y., Li, B., Huang, C. L., Chen, H. D., Chen, J., Luo, Y., Guo, H., Jiang, R. D., Liu, M. Q., Chen, Y., Shen, X. R., Wang, X., Zheng, X. S., … Shi, Z. L. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798), 270-273. https://doi.org/10.1038/s41586-020-2012-7

Zou, X., Chen, K., Zou, J., Han, P., Hao, J., & Han, Z. (2020). Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Frontiers of medicine, 14(2), 185-192. https://doi.org/10.1007/s11684-020-0754-0

Wadman, M., Couzin-Frankel, J., Kaiser, J., & Matacic, C. (2020). A rampage through the body. Science, 368(6489), 356-360. https://doi.org/10.1126/science.368.6489.356

Verdecchia, P., Cavallini, C., Spanevello, A., & Angeli, F. (2020). The pivotal link between ACE2 deficiency and SARS-CoV-2 infection. European journal of internal medicine, 76, 14-20. https://doi.org/10.1016/j.ejim.2020.04.037

Gupta, A., Madhavan, M. V., Sehgal, K., Nair, N., Mahajan, S., Sehrawat, T. S., Bikdeli, B., Ahluwalia, N., Ausiello, J. C., Wan, E. Y., Freedberg, D. E., Kirtane, A. J., Parikh, S. A., Maurer, M. S., Nordvig, A. S., Accili, D., Bathon, J. M., Mohan, S., Bauer, K. A., Leon, M. B., … Landry, D. W. (2020). Extrapulmonary manifestations of COVID-19. Nature medicine, 26(7), 1017-1032. https://doi.org/10.1038/s41591-020-0968-3

Ministry of Health of Ukraine. (2014, September 17). Pro vnesennia zmin do Standartiv medychnoi dopomogy [On amendments to the Standards of medical care "Coronavirus disease (COVID-19) (No. 2122)]. https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-17092020--2122pro-vnesennja-zmin-do-standartiv-medichnoi-dopomogi-koronavirusna-hvoroba-covid-19

Yin, X., Xu, X., Li, H., Jiang, N., Wang, J., Lu, Z., Xiong, N., & Gong, Y. (2022). Evaluation of early antibiotic use in patients with non-severe COVID-19 without bacterial infection. International journal of antimicrobial agents, 59(1), 106462. https://doi.org/10.1016/j.ijantimicag.2021.106462

Hyts, A R. (2021). COVID-19: sprostovana efektyvnist antybiotykoterapii [COVID-19: refuted effectiveness of antibiotic therapy]. Ukrainskiy medychnyi chasopys. [in Ukrainian]. https://www.umj.com.ua/article/199629/covid-19-sprostovana-efektivnist-antibiotikoterapiyi

Bouteleux, B., Henrot, P., Ernst, R., Grassion, L., Raherison-Semjen, C., Beaufils, F., Zysman, M., & Delorme, M. (2021). Respiratory rehabilitation for Covid-19 related persistent dyspnoea: A one-year experience. Respiratory medicine, 189, 106648. https://doi.org/10.1016/j.rmed.2021.106648

Buttery, S., Philip, K., Williams, P., Fallas, A., West, B., Cumella, A., Cheung, C., Walker, S., Quint, J. K., Polkey, M. I., & Hopkinson, N. S. (2021). Patient symptoms and experience following COVID-19: results from a UK-wide survey. BMJ open respiratory research, 8(1), e001075. https://doi.org/10.1136/bmjresp-2021-001075

Darley, D. R., Dore, G. J., Cysique, L., Wilhelm, K. A., Andresen, D., Tonga, K., Stone, E., Byrne, A., Plit, M., Masters, J., Tang, H., Brew, B., Cunningham, P., Kelleher, A., & Matthews, G. V. (2021). Persistent symptoms up to four months after community and hospital-managed SARS-CoV-2 infection. The Medical journal of Australia, 214(6), 279-280. https://doi.org/10.5694/mja2.50963

Lerum, T. V., Aaløkken, T. M., Brønstad, E., Aarli, B., Ikdahl, E., Lund, K., Durheim, M. T., Rodriguez, J. R., Meltzer, C., Tonby, K., Stavem, K., Skjønsberg, O. H., Ashraf, H., & Einvik, G. (2021). Dyspnoea, lung function and CT findings 3 months after hospital admission for COVID-19. The European respiratory journal, 57(4), 2003448. https://doi.org/10.1183/13993003.03448-2020

Griffiths, J., Hatch, R. A., Bishop, J., Morgan, K., Jenkinson, C., Cuthbertson, B. H., & Brett, S. J. (2013). An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study. Critical care, 17(3), R100. https://doi.org/10.1186/cc12745

Davidson, J. E., Jones, C., & Bienvenu, O. J. (2012). Family response to critical illness: postintensive care syndrome-family. Critical care medicine, 40(2), 618-624. https://doi.org/10.1097/CCM.0b013e318236ebf9

Cortinovis M., Perico N. & Remuzzi G. (2021). Long-term follow-up of recovered patients with COVID-19. Lancet, 397(10270), 173-175. https://doi.org/10.1016/S0140-6736(21)00039-8

Moreno-Pérez, O., Merino, E., Leon-Ramirez, J. M., Andres, M., Ramos, J. M., Arenas-Jiménez, J., Asensio, S., Sanchez, R., Ruiz-Torregrosa, P., Galan, I., Scholz, A., Amo, A., González-delaAleja, P., Boix, V., Gil, J., & COVID19-ALC research group (2021). Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study. The Journal of infection, 82(3), 378-383. https://doi.org/10.1016/j.jinf.2021.01.004

Tenforde, M. W., Kim, S. S., Lindsell, C. J., Billig Rose, E., Shapiro, N. I., Files, D. C., Gibbs, K. W., Erickson, H. L., Steingrub, J. S., Smithline, H. A., Gong, M. N., Aboodi, M. S., Exline, M. C., Henning, D. J., Wilson, J. G., Khan, A., Qadir, N., Brown, S. M., Peltan, I. D., Rice, T. W., … IVY Network Investigators (2020). Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network - United States, March-June 2020. MMWR. Morbidity and mortality weekly report, 69(30), 993-998. https://doi.org/10.15585/mmwr.mm6930e1

Carvalho-Schneider, C., Laurent, E., Lemaignen, A., Beaufils, E., Bourbao-Tournois, C., Laribi, S., Flament, T., Ferreira-Maldent, N., Bruyère, F., Stefic, K., Gaudy-Graffin, C., Grammatico-Guillon, L., & Bernard, L. (2021). Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clinical microbiology and infection, 27(2), 258-263. https://doi.org/10.1016/j.cmi.2020.09.052

Published

2022-12-20

How to Cite

1.
Melnyk VP, Panasiuk ОV, Sadomova-Andrianova HV, Zahuta YB, Antoniuk IV, Sliusarchuk IO, Melnyk IV. Post-COVID syndrome. Zaporozhye medical journal [Internet]. 2022Dec.20 [cited 2024Mar.19];24(6):701-9. Available from: http://zmj.zsmu.edu.ua/article/view/252741

Issue

Section

Original research