Analysis of results in patients after treatment using various segmental bone alloplasty techniques

Authors

DOI:

https://doi.org/10.14739/2310-1210.2022.3.252811

Keywords:

malignant bone tumors, bone cancer, sarcoma, bone allograft, surgical treatment

Abstract

Restoration of bone, adjacent joint and surrounding soft tissue integrity is an important factor in achieving full function of affected limbs in patients with bone tumors. Biological bone reconstruction has a number of advantages over other artificial implants.

The aim of the work is to analyze the results of clinical approbation of the segmental alloimplant using by different methods for treatment of malignant bone tumors.

Material and methods. The data of 17 patients with malignant tumors, secondary lesions or neoplasms of long bones with an aggressive course of the pathological process were analyzed. All patients underwent surgery to remove en-block tumors and replace post-resection defects of long bones with segmental bone alloimplants. Different methods of fixing bone alloimplants and sterilization of alloimplants were used. Three methods of surgery are presented.

Results. The analysis of surgical treatment results in patients with long bone tumors who underwent bioreconstructive surgery was performed. The functional results according to the MSTS scale and complications of bioreconstructive operations according to the classification of Henderson E. et al. were assessed. The total number of complications was 58.8 %, among which local complications of the wound process were observed in 5.9 % of cases (1 patient), atrophic nonunion of the recipient bone and alloimplant – in 4 cases (23.5 %), violation of the metal fixator integrity – in 2 patients 11.8 %), infectious complications – in 5.9 % (1 patient), local recurrence of the tumor was the most common and amounted to 35.3 % (6 patients) of all cases.

Conclusions. Bioreconstructive surgical interventions (using bone alloimplants) should be used according to clear indications to achieve the best results. The application of the developed methods presented in the work will reduce the risk of complications associated with bone alloplasty. Biological recovery of lost bone tissue and the fastest recovery of the affected limb through the use of metal structures allows a widespread use of this technique in cancer patients.

Author Biographies

Ya. O. Holovina, SI “Sytenko Institute of Spine and Joint Pathology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, Senior Researcher of the Department of Bone Tumor Department

R. V. Malyk, Kharkov Medical Academy of Postgraduate Education, Ukraine

MD, PhD, Assistant of the Department of Traumatology and Orthopedics

O. Ye. Vyrva, SI “Sytenko Institute of Spine and Joint Pathology of the National Academy of Medical Sciences of Ukraine”, Kharkiv

MD, PhD, DSc, Professor, Chief Physician, Head of the Department of Bone Tumor

References

Gautam, D., Arora, N., Gupta, S., George, J., & Malhotra, R. (2021). Megaprosthesis Versus Allograft Prosthesis Composite for the Management of Massive Skeletal Defects: A Meta-Analysis of Comparative Studies. Current Reviews in Musculoskeletal Medicine, 14(3), 255-270. https://doi.org/10.1007/s12178-021-09707-6

Benedetti, M. G., Bonatti, E., Malfitano, C., & Donati, D. (2013). Comparison of allograft-prosthetic composite reconstruction and modular prosthetic replacement in proximal femur bone tumors: functional assessment by gait analysis in 20 patients. Acta Orthopaedica, 84(2), 218-223. https://doi.org/10.3109/17453674.2013.773119

Baldwin, P., Li, D. J., Auston, D. A., Mir, H. S., Yoon, R. S., & Koval, K. J. (2019). Autograft, Allograft, and Bone Graft Substitutes: Clinical Evidence and Indications for Use in the Setting of Orthopaedic Trauma Surgery. Journal of Orthopaedic Trauma, 33(4), 203-213. https://doi.org/10.1097/BOT.0000000000001420

Perez, J. R., Jose, J., Mohile, N. V., Boden, A. L., Greif, D. N., Barrera, C. M., Conway, S., Subhawong, T., Ugarte, A., & Pretell-Mazzini, J. (2020). Limb salvage reconstruction: Radiologic features of common reconstructive techniques and their complications. Journal of Orthopaedics, 21, 183-191. https://doi.org/10.1016/j.jor.2020.03.043

Gharedaghi, M., Peivandi, M. T., Mazloomi, M., Shoorin, H. R., Hasani, M., Seyf, P., & Khazaee, F. (2016). Evaluation of Clinical Results and Complications of Structural Allograft Reconstruction after Bone Tumor Surgery. The Archives of Bone and Joint Surgery, 4(3), 236-242.

Henderson, E. R., O'Connor, M. I., Ruggieri, P., Windhager, R., Funovics, P. T., Gibbons, C. L., Guo, W., Hornicek, F. J., Temple, H. T., & Letson, G. D. (2014). Classification of failure of limb salvage after reconstructive surgery for bone tumours: a modified system Including biological and expandable reconstructions. The Bone & Joint Journal, 96-B(11), 1436-1440. https://doi.org/10.1302/0301-620X.96B11.34747

McGoveran, B. M., Davis, A. M., Gross, A. E., & Bell, R. S. (1999). Evaluation of the allograft-prosthesis composite technique for proximal femoral reconstruction after resection of a primary bone tumour. Canadian Journal of Surgery, 42(1), 37-45.

Reif, T., Schoch, B., Spiguel, A., Elhassan, B., Wright, T., Sanchez-Sotelo, J., & Wilke, B. K. (2020). A retrospective review of revision proximal humeral allograft-prosthetic composite procedures: an analysis of proximal humeral bone stock restoration. Journal of Shoulder and Elbow Surgery, 29(7), 1353-1358. https://doi.org/10.1016/j.jse.2019.10.029

Biau, D. J., Larousserie, F., Thévenin, F., Piperno-Neumann, S., & Anract, P. (2010). Results of 32 Allograft-prosthesis Composite Reconstructions of the Proximal Femur. Clinical Orthopaedics and Related Research, 468(3), 834-845. https://doi.org/10.1007/s11999-009-1132-z

Mankin, H. J., Hornicek, F. J., & Raskin, K. A. (2005). Infection in Massive Bone Allografts. Clinical Orthopaedics and Related Research, 432, 210-216. https://doi.org/10.1097/01.blo.0000150371.77314.52

Min, L., Peng, J., Duan, H., Zhang, W., Zhou, Y., & Tu, C. (2014). Uncemented allograft-prosthetic composite reconstruction of the proximal femur. Indian Journal of Orthopaedics, 48(3), 289-295. https://doi.org/10.4103/0019-5413.132521

Cascio, B. M., Thomas, K. A., & Wilson, S. C. (2003). A Mechanical Comparison and Review of Transverse, Step-Cut, and Sigmoid Osteotomies. Clinical Orthopaedics and Related Research, 411, 296-304. https://doi.org/10.1097/01.blo.0000069895.31220.e8

Muscolo, D. L., Farfalli, G. L., Aponte-Tinao, L. A., & Ayerza, M. A. (2009). Proximal Femur Allograft-prosthesis with Compression Plates and a Short Stem. Clinical Orthopaedics and Related Research, 468(1), 224-230. https://doi.org/10.1007/s11999-009-0903-x

Miller, B. J., & Virkus, W. W. (2010). Intercalary Allograft Reconstructions Using a Compressible Intramedullary Nail: A Preliminary Report. Clinical Orthopaedics and Related Research, 468(9), 2507-2513. https://doi.org/10.1007/s11999-010-1260-5

Aponte-Tinao, L. A., Ayerza, M. A., Albergo, J. I., & Farfalli, G. L. (2020). Do Massive Allograft Reconstructions for Tumors of the Femur and Tibia Survive 10 or More Years after Implantation? Clinical Orthopaedics and Related Research, 478(3), 517-524. https://doi.org/10.1097/corr.0000000000000806

Hornicek, F. J., Gebhardt, M. C., Tomford, W. W., Sorger, J. I., Zavatta, M., Menzner, J. P., & Mankin, H. J. (2001). Factors Affecting Nonunion of the Allograft-Host Junction. Clinical Orthopaedics and Related Research, 382, 87-98. https://doi.org/10.1097/00003086-200101000-00014

Vyrva, O. Ye., Golovina, Ya. O., Malyk, R. V., & Golovina, O. O. (2021). Udoskonalennia metodyky alokompozytnoho endoprotezuvannia [Improvement of allograft-prosthetic composite reconstruction]. Klinichna onkolohiia, 11(1), 1-9. https://doi.org/10.32471/clinicaloncology.2663-466x.41-1.27933 [in Ukrainian].

Published

2022-05-30

How to Cite

1.
Holovina YO, Malyk RV, Vyrva OY. Analysis of results in patients after treatment using various segmental bone alloplasty techniques. Zaporozhye Medical Journal [Internet]. 2022May30 [cited 2024Nov.20];24(3):322-7. Available from: http://zmj.zsmu.edu.ua/article/view/252811

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Section

Original research