Other specific types of diabetes mellitus

Authors

  • V. G. Kadzharyan
  • A. I. Melnyk
  • P. P. Bidzilya
  • A. O. Solovyuk

DOI:

https://doi.org/10.14739/2310-1210.2014.2.25436

Keywords:

MODY diabetes, diabetes LADA

Abstract

Over the last decade it became obvious that not all cases of diabetes that has developed in childhood and adolescence, as well as at an older age, are diabetes type 1 and 2. Patients often unable to identify MODY and LADA type of diabetes, as well as more rare syndromal form. This article reflects the modern view on etiology, pathogenesis, clinic and diagnostics of MODY and LADA diabetes that allows to precise diagnosis and appointment of a patient pathogenetic therapy.

References

Barret T.G., Ehtisham S. The emergence of type 2 diabetes in childhood. Ann. Clin. Biochem 2004; 41: 10-16

Fajans S.S., Conn J.W. The use of tolbutamidein the treatment of young people with mild diabetes mellitus - a progressreport. Diabetes 1962;11:123-126.

Tattersall R.B., Mansell P.I. Maturity onsettypediabetes of the young (MODY): one condition or many. Diabet Med 1991;8:402–410

Barret T.G. Differential diagnosis of type 1 diabetes: which genetic syndromes need to be considered. Pediatric Diabetes. 2007; 8(149): 15-23.

Bell G.L., Xiang K.-S., Newman M.V. et al. Gene for non-insulin-dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc. Natl. Acad. Sci. USA 1991;88: 1484-1488.

Njolstad P.R., Molven A, Sovik O. Chiarelli F., Dahl-Jogensen K., Kiess W. Karger. Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity. In «Diabetes in childhood and Adolescence» 2005; 86-93.

Tattersall R.B., Fajans S.S. A difference betweenthe inheritance of classical juvenileonsetand maturity-onset type diabetes of young people. Diabetes 1975; 24: 44-53

Owen K.R., Thanabalasingham G., JamesT.J. et al. Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminatorof maturity-onset diabetes of the young due to HNF1A mutations. DiabetesCare 2010; 33:1919–1924

Froguel P., Zouali H., Vionnet N. Familial hyperglycaemia due to mutations in glucokinase: definition of a subtype of diabetes mellitus. N. Engl. J. Med. 1993;328: 697-702.

Shih D.Q., Dansky H.M., Fleisher M.,Assmann G., Fajans S.S., Stoffel M. Genotype (phenotype) relationships in HNF-4a MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein(CIII), lipoprotein(a), and triglyceridelevels. Diabetes 2000;49: 832–837.

Hattersley A., Bruining J., Shield J.,Njolstad P.,Donaghue K.C. The diagnosis and managementof monogenic diabetes in childrenand adolescents. Pediatr. Diabetes. 2009;10(Suppl. 12):33–42

Cuesta-Muñoz A.L., Tuomi T., Cobo-Vuilleumier N., et al. Clinical heterogeneityin monogenic diabetes caused by mutations in the glucokinase gene (GCKMODY).Diabetes Care 2010;33:290–292

The Diabetes Prevention Trials- Type 1Study Group. Effects of oral insulin in relatives of patients with type 1 Diabetes. Diabetes Care 2005; 28: 1068-1076.

Fajans S.S., Bell G.I. Phenotypic heterogeneity between different mutations of MODY subtypes and within MODY pedigrees. Diabetologia 2006;49:1106–1108

Raeder, H., Johansson, S., Holm, P.I., Haldorsen, I.S., Mas, E., Sbarra, V., Nermoen, I., Eide, S.A., Grevle, L., Bjørkhaug, L., Sagen, J.V., Aksnes, L., Søvik, O., Lombardo, D., Molven, A., Njølstad, P.R. Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. Nat. Genet. 2006; 1-18.

Palmer J.P., Hirsch I.B. What’s in a name: latent autoimmune diabetes of adults, type 1.5, adult-onset, and type 1 diabetes. Diabetes Care 2003; 26: 536—538.

Pozzilli P., Di Mario U. Autoimmune diabetes not requiring insulin at diagnosis (latent autoimmune diabetes of the adult): definition, characterization, and potential prevention. Diabetes Care. 2001; 24: 1460—1467.

Zimmet P.Z., Tuomi T., Mackay I.R. et al. Latent autoimmune diabetes mellitus in adults (LADA): the role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet.Med. 1994; 11 : 299—303.

Borg H., Gottsäter A., Fernlund P., Sundkvist G. A 12-year prospective study of the relationship between islet antibodies and β-cell function at and after the diagnosis in patients with adult-onset diabetes. Diabetes 2002; 51: 1754—1762.

Kobayashi T., Tamemoto K., Nakanishi K. et al. Immunogenetic and clinical characterization of slowly progressive IDDM. Diabetes Care. 1993; 16: 780—788.

Tuomi T., Carlsson A., Li H. et al. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 1999; 48: 150—157.

Turner R., Stratton I., Horton V. et al. UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet.1997; 350: 1288—1293.

Hosszufalusi N., Vatay A., Rajczy K. et al. Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression. Diabetes Care 2003; 26: 452—457.

Кононенко И.В. Функциональное состояние β-клеток, периферическая чувствительность к инсулину, метаболизм глюкозы у больных с поздним аутоиммунным началом сахарного диабета в дебюте заболевания. Автореф. дис. канд. мед. наук. М. 2003; 21.

Cervin C., Lyssenko V., Bakhtadze E. et al. Genetic similarities between latent autoimmune diabetes in adults, type 1 diabetes, and type 2 diabetes. Diabetes 2008; 57: 1433—1437.

Brusko T.M., Wasserfall C.H., Clare-Salzler M.J. et al. Functional defects and the influence of age on the frequency of CD+4CD+25 T-cells in type 1 diabetes. Diabetes 2005; 54: 1407—1414.

Tang Q., Bluestone J.A. Regulatory T-cell physiology application to treat autoimmunity. Immunol. Rev. 2006; 212: 217—237.

Lindley S., Dayan C.M., Bishop A. et al. Defective suppressor function in CD4+CD25+ T cells from patients with type 1 diabetes. Diabetes 2005; 54: 92–99.

Tabeeva KI . V. Nikonov, OM Smirnov. Polyglandular autoimmune syndrome type III (DTZ, type 1 diabetes, autoimmune glomerulonephritis). Diabetes 2004, 4: 30-32.

Nikonov TV, Apanovich PV, EV Pekareva et al. Immunogenetic aspects of slowly progressive autoimmune diabetes in adults (LADA). Diabetes in 2011, 1: 28-33

Downloads

How to Cite

1.
Kadzharyan VG, Melnyk AI, Bidzilya PP, Solovyuk AO. Other specific types of diabetes mellitus. Zaporozhye Medical Journal [Internet]. 2014Jun.19 [cited 2024Nov.2];16(2). Available from: http://zmj.zsmu.edu.ua/article/view/25436

Issue

No. 2 (2014): Zaporozhye medical journal

Section

Review

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.  Лицензия Creative Commons
    2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
    3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access)